Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease
Autor(a) principal: | |
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Data de Publicação: | 1993 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/29055 |
Resumo: | Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 45, 90 and 170-day-intervals after treatment (185, 210 and 290 days after primoinfection, respectively). Recovery of worms at 20 days after reinfections showed that a residual immunity remains up to 90 days after treatment, and disappears at 170 days after cure. Using the ELISA method, it was possible to detect a decrease of antibody levels (total IgG) in the treated group, when antigens from different evolutive stages of S. mansoni were used. The epidemiological implications of the present results, and the possible mechanisms involved in the decrease of acquired immunity after treatment are discussed. |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença Schistosoma mansoniChemotherapyResidual immunityConcomitant immunity Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 45, 90 and 170-day-intervals after treatment (185, 210 and 290 days after primoinfection, respectively). Recovery of worms at 20 days after reinfections showed that a residual immunity remains up to 90 days after treatment, and disappears at 170 days after cure. Using the ELISA method, it was possible to detect a decrease of antibody levels (total IgG) in the treated group, when antigens from different evolutive stages of S. mansoni were used. The epidemiological implications of the present results, and the possible mechanisms involved in the decrease of acquired immunity after treatment are discussed. Para evidenciar a queda da imunidade adquirida após cura quimioterápica, um lote de camundongos foi infectado com ±25 cercárías de S. mansoni (cepa LE). Parte destes animais foi tratada aos 120 dias com 400 mg/kg de oxamniquina. Foram feitos desafios em intervalos de 45, 90 e 170 dias após o tratamento (185, 210 e 290 dias após a primoinfecção, respectivamente). A recuperação aos 20 dias após as infecções desafio, dos vermes das reinfecções mostrou que a imunidade residual persiste até os 90 dias após o tratamento e desaparece aos 170 dias após a cura. Com o soro dos camundongos, através do método de ELISA, evidenciou-se uma queda nos níveis de anticorpos (IgG total) no grupo tratado em relação a vários antígenos de estágios evolutivos do S. mansoni. As implicações epidemiológicas dos presentes resultados e os possíveis mecanismos envolvidos na queda da imunidade adquirida após tratamento são discutidos. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1993-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29055Revista do Instituto de Medicina Tropical de São Paulo; Vol. 35 No. 4 (1993); 337-344 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 35 Núm. 4 (1993); 337-344 Revista do Instituto de Medicina Tropical de São Paulo; v. 35 n. 4 (1993); 337-344 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29055/30912Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBezerra, Fernando Schemelzer de MoraesCoelho, Paulo Marcos ZechTavares, Carlos Alberto Pereira2012-07-02T01:35:46Zoai:revistas.usp.br:article/29055Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:48.874907Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença |
title |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease |
spellingShingle |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Bezerra, Fernando Schemelzer de Moraes Schistosoma mansoni Chemotherapy Residual immunity Concomitant immunity |
title_short |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease |
title_full |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease |
title_fullStr |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease |
title_full_unstemmed |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease |
title_sort |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease |
author |
Bezerra, Fernando Schemelzer de Moraes |
author_facet |
Bezerra, Fernando Schemelzer de Moraes Coelho, Paulo Marcos Zech Tavares, Carlos Alberto Pereira |
author_role |
author |
author2 |
Coelho, Paulo Marcos Zech Tavares, Carlos Alberto Pereira |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Bezerra, Fernando Schemelzer de Moraes Coelho, Paulo Marcos Zech Tavares, Carlos Alberto Pereira |
dc.subject.por.fl_str_mv |
Schistosoma mansoni Chemotherapy Residual immunity Concomitant immunity |
topic |
Schistosoma mansoni Chemotherapy Residual immunity Concomitant immunity |
description |
Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 45, 90 and 170-day-intervals after treatment (185, 210 and 290 days after primoinfection, respectively). Recovery of worms at 20 days after reinfections showed that a residual immunity remains up to 90 days after treatment, and disappears at 170 days after cure. Using the ELISA method, it was possible to detect a decrease of antibody levels (total IgG) in the treated group, when antigens from different evolutive stages of S. mansoni were used. The epidemiological implications of the present results, and the possible mechanisms involved in the decrease of acquired immunity after treatment are discussed. |
publishDate |
1993 |
dc.date.none.fl_str_mv |
1993-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29055 |
url |
https://www.revistas.usp.br/rimtsp/article/view/29055 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29055/30912 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 35 No. 4 (1993); 337-344 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 35 Núm. 4 (1993); 337-344 Revista do Instituto de Medicina Tropical de São Paulo; v. 35 n. 4 (1993); 337-344 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951640486641664 |