Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/29379 |
Resumo: | To evaluate the effect of concurrent infection by HIV on HBV infection or immunity, we have studied a group of 66 HIV1+ symptomatic Caucasian patients and another of 38 African HIV2+ asymptomatic individuals, concerning their HBV status: serological markers of infection and presence of HBV-DNA in serum, the last taken as sign of hepatitis B virus active replication, were monitored. HIV+ groups were compared with seronegative controls, adequately matched for age, sex and ethnological background. HBV DNA was found in 7.6% of HIV1+ Caucasian patients and 3.2% of seronegative controls; in African HIV2+ individuals 2.6% were also HBV DNA+, a percentage close to that found in HIV2 seronegative controls (2.9%). No correlation was found between HIV infection and HBV active replication. Immunodepression that follows HIV infection over time may be compatible with a degree of T cell function capable of avoiding reinfection with or reactivation of HBV, even in symptomatic stages of acquired immunodeficiency syndrome. Our findings are relevant to the choice of preventive strategies in populations at risk for HIV and HBV infection. |
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Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients Replicação ativa do vírus da hepatite B (HBV) em doentes infectados pelo vírus da imunodeficiência humana (HIV) de tipo 1 ou de tipo 2 HIVHBV active replication To evaluate the effect of concurrent infection by HIV on HBV infection or immunity, we have studied a group of 66 HIV1+ symptomatic Caucasian patients and another of 38 African HIV2+ asymptomatic individuals, concerning their HBV status: serological markers of infection and presence of HBV-DNA in serum, the last taken as sign of hepatitis B virus active replication, were monitored. HIV+ groups were compared with seronegative controls, adequately matched for age, sex and ethnological background. HBV DNA was found in 7.6% of HIV1+ Caucasian patients and 3.2% of seronegative controls; in African HIV2+ individuals 2.6% were also HBV DNA+, a percentage close to that found in HIV2 seronegative controls (2.9%). No correlation was found between HIV infection and HBV active replication. Immunodepression that follows HIV infection over time may be compatible with a degree of T cell function capable of avoiding reinfection with or reactivation of HBV, even in symptomatic stages of acquired immunodeficiency syndrome. Our findings are relevant to the choice of preventive strategies in populations at risk for HIV and HBV infection. A fim de avaliar as conseqüências da infecção por HIV no curso da infecção por HBV, ou na imunidade anteriormente adquirida, estudamos um grupo de 66 doentes Caucasóides HIV1+ sintomáticos e outro de 38 indivíduos seropositivos para HIV2 e provenientes da África, quanto a marcadores serológicos de infecção por HBV e quanto à presença de DNA viral circulante, tomada como sinal de replicação ativa do vírus da hepatite. Os grupos HIV+ foram comparados com controles seronegativos adequados tendo-se verificado que 7.6% dos doentes HIV1+ eram também HBV-DNA+ (versus 3.2% nos seronegativos) bem como 2.6% dos HIV2+ (versus 2.9% nos controles seronegativos), não sendo as diferenças estatisticamente significativas em qualquer um dos casos e não tendo sido encontrada correlação entre infecção por HIV e replicação ativa de HBV. A imunodeficiência que se instala progressivamente após infecção por HIV, poderá ser compatível com um grau de vigilância T suficiente para impedir reinfecção ou reativação de HBV, mesmo em indivíduos já sintomáticos. Os nossos resultados são relevantes para a escolha de estratégias preventivas da hepatite B em gupos com risco de infecção por HIV. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1996-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29379Revista do Instituto de Medicina Tropical de São Paulo; Vol. 38 No. 4 (1996); 253-258 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 38 Núm. 4 (1996); 253-258 Revista do Instituto de Medicina Tropical de São Paulo; v. 38 n. 4 (1996); 253-258 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29379/31236Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBarros, M.F.Piedade, J.Nunes, G.Canas-Ferreira, W.Silva, A.P.Champalimaud, J.L.Machado-Caetano, J.A.2012-07-02T01:43:48Zoai:revistas.usp.br:article/29379Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:07.551279Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients Replicação ativa do vírus da hepatite B (HBV) em doentes infectados pelo vírus da imunodeficiência humana (HIV) de tipo 1 ou de tipo 2 |
title |
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients |
spellingShingle |
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients Barros, M.F. HIV HBV active replication |
title_short |
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients |
title_full |
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients |
title_fullStr |
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients |
title_full_unstemmed |
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients |
title_sort |
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients |
author |
Barros, M.F. |
author_facet |
Barros, M.F. Piedade, J. Nunes, G. Canas-Ferreira, W. Silva, A.P. Champalimaud, J.L. Machado-Caetano, J.A. |
author_role |
author |
author2 |
Piedade, J. Nunes, G. Canas-Ferreira, W. Silva, A.P. Champalimaud, J.L. Machado-Caetano, J.A. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Barros, M.F. Piedade, J. Nunes, G. Canas-Ferreira, W. Silva, A.P. Champalimaud, J.L. Machado-Caetano, J.A. |
dc.subject.por.fl_str_mv |
HIV HBV active replication |
topic |
HIV HBV active replication |
description |
To evaluate the effect of concurrent infection by HIV on HBV infection or immunity, we have studied a group of 66 HIV1+ symptomatic Caucasian patients and another of 38 African HIV2+ asymptomatic individuals, concerning their HBV status: serological markers of infection and presence of HBV-DNA in serum, the last taken as sign of hepatitis B virus active replication, were monitored. HIV+ groups were compared with seronegative controls, adequately matched for age, sex and ethnological background. HBV DNA was found in 7.6% of HIV1+ Caucasian patients and 3.2% of seronegative controls; in African HIV2+ individuals 2.6% were also HBV DNA+, a percentage close to that found in HIV2 seronegative controls (2.9%). No correlation was found between HIV infection and HBV active replication. Immunodepression that follows HIV infection over time may be compatible with a degree of T cell function capable of avoiding reinfection with or reactivation of HBV, even in symptomatic stages of acquired immunodeficiency syndrome. Our findings are relevant to the choice of preventive strategies in populations at risk for HIV and HBV infection. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29379 |
url |
https://www.revistas.usp.br/rimtsp/article/view/29379 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29379/31236 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 38 No. 4 (1996); 253-258 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 38 Núm. 4 (1996); 253-258 Revista do Instituto de Medicina Tropical de São Paulo; v. 38 n. 4 (1996); 253-258 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951642255589376 |