Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/173932 |
Resumo: | This study analyzed possible associations between the trimester of maternal Zika virus infection (ZIKV) in pregnancy, severity of brain computed tomography (CT) findings and the presence of microcephaly at birth in children with Congenital Zika Syndrome (CZS). It was an analytical study in a cohort of children with CZS. Symptoms of maternal infection were dichotomized into the 1st trimester of pregnancy and other trimesters. Head circumference (HC) at birth was used to calculate the z-score. Mild microcephaly was defined as HC between 2 and ≥3 standard deviations (SD) below the mean for each gestational age and sex, and severe microcephaly when HC <3 SD below average. Brain CT images were evaluated by two radiologists and classified, according to the severity, into mild, moderate and severe. Fisher’s exact, Mann-Whitney and Kruskal-Wallis tests were used to verify the associations between variables. In 108 children, maternal infection in the 1st trimester of pregnancy was associated with more severe brain CT abnormalities (p=0.038), greater severity of microcephaly at birth (p=0.013) and lower HC z-scores at birth (p=0.021). The severity of brain CT lesions was also associated with lower HC z-scores at birth (p<0.001). Maternal ZIKV infection during the first trimester of pregnancy proved to be an important risk factor for a more severe spectrum of CZS, as it is associated with more severe brain CT abnormalities and, consequently, with lower HC z-scores at birth. |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birthZika virusZika virus infectionCongenital abnormalitiesBrain computed tomographyMicrocephaly.This study analyzed possible associations between the trimester of maternal Zika virus infection (ZIKV) in pregnancy, severity of brain computed tomography (CT) findings and the presence of microcephaly at birth in children with Congenital Zika Syndrome (CZS). It was an analytical study in a cohort of children with CZS. Symptoms of maternal infection were dichotomized into the 1st trimester of pregnancy and other trimesters. Head circumference (HC) at birth was used to calculate the z-score. Mild microcephaly was defined as HC between 2 and ≥3 standard deviations (SD) below the mean for each gestational age and sex, and severe microcephaly when HC <3 SD below average. Brain CT images were evaluated by two radiologists and classified, according to the severity, into mild, moderate and severe. Fisher’s exact, Mann-Whitney and Kruskal-Wallis tests were used to verify the associations between variables. In 108 children, maternal infection in the 1st trimester of pregnancy was associated with more severe brain CT abnormalities (p=0.038), greater severity of microcephaly at birth (p=0.013) and lower HC z-scores at birth (p=0.021). The severity of brain CT lesions was also associated with lower HC z-scores at birth (p<0.001). Maternal ZIKV infection during the first trimester of pregnancy proved to be an important risk factor for a more severe spectrum of CZS, as it is associated with more severe brain CT abnormalities and, consequently, with lower HC z-scores at birth.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2020-08-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/rimtsp/article/view/17393210.1590/s1678-9946202062056Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e56Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e56Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e561678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/173932/162931https://www.revistas.usp.br/rimtsp/article/view/173932/162932Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMendes, Ana Karolina TorresRibeiro, Marizélia Rodrigues CostaLamy-Filho, FernandoAmaral, Gláucio AndradeBorges, Marcella Costa RibeiroCosta, Luciana CavalcanteCavalcante, Tamires BarradasBatista, Rosângela Fernandes LucenaSousa, Patrícia da SilvaSilva, Antônio Augusto Moura da2020-10-26T17:39:25Zoai:revistas.usp.br:article/173932Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:53.624279Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth |
title |
Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth |
spellingShingle |
Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth Mendes, Ana Karolina Torres Zika virus Zika virus infection Congenital abnormalities Brain computed tomography Microcephaly. |
title_short |
Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth |
title_full |
Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth |
title_fullStr |
Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth |
title_full_unstemmed |
Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth |
title_sort |
Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth |
author |
Mendes, Ana Karolina Torres |
author_facet |
Mendes, Ana Karolina Torres Ribeiro, Marizélia Rodrigues Costa Lamy-Filho, Fernando Amaral, Gláucio Andrade Borges, Marcella Costa Ribeiro Costa, Luciana Cavalcante Cavalcante, Tamires Barradas Batista, Rosângela Fernandes Lucena Sousa, Patrícia da Silva Silva, Antônio Augusto Moura da |
author_role |
author |
author2 |
Ribeiro, Marizélia Rodrigues Costa Lamy-Filho, Fernando Amaral, Gláucio Andrade Borges, Marcella Costa Ribeiro Costa, Luciana Cavalcante Cavalcante, Tamires Barradas Batista, Rosângela Fernandes Lucena Sousa, Patrícia da Silva Silva, Antônio Augusto Moura da |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mendes, Ana Karolina Torres Ribeiro, Marizélia Rodrigues Costa Lamy-Filho, Fernando Amaral, Gláucio Andrade Borges, Marcella Costa Ribeiro Costa, Luciana Cavalcante Cavalcante, Tamires Barradas Batista, Rosângela Fernandes Lucena Sousa, Patrícia da Silva Silva, Antônio Augusto Moura da |
dc.subject.por.fl_str_mv |
Zika virus Zika virus infection Congenital abnormalities Brain computed tomography Microcephaly. |
topic |
Zika virus Zika virus infection Congenital abnormalities Brain computed tomography Microcephaly. |
description |
This study analyzed possible associations between the trimester of maternal Zika virus infection (ZIKV) in pregnancy, severity of brain computed tomography (CT) findings and the presence of microcephaly at birth in children with Congenital Zika Syndrome (CZS). It was an analytical study in a cohort of children with CZS. Symptoms of maternal infection were dichotomized into the 1st trimester of pregnancy and other trimesters. Head circumference (HC) at birth was used to calculate the z-score. Mild microcephaly was defined as HC between 2 and ≥3 standard deviations (SD) below the mean for each gestational age and sex, and severe microcephaly when HC <3 SD below average. Brain CT images were evaluated by two radiologists and classified, according to the severity, into mild, moderate and severe. Fisher’s exact, Mann-Whitney and Kruskal-Wallis tests were used to verify the associations between variables. In 108 children, maternal infection in the 1st trimester of pregnancy was associated with more severe brain CT abnormalities (p=0.038), greater severity of microcephaly at birth (p=0.013) and lower HC z-scores at birth (p=0.021). The severity of brain CT lesions was also associated with lower HC z-scores at birth (p<0.001). Maternal ZIKV infection during the first trimester of pregnancy proved to be an important risk factor for a more severe spectrum of CZS, as it is associated with more severe brain CT abnormalities and, consequently, with lower HC z-scores at birth. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/173932 10.1590/s1678-9946202062056 |
url |
https://www.revistas.usp.br/rimtsp/article/view/173932 |
identifier_str_mv |
10.1590/s1678-9946202062056 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/173932/162931 https://www.revistas.usp.br/rimtsp/article/view/173932/162932 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e56 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e56 Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e56 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951652730863616 |