Hepatitis C viral load does not predict disease outcome: going beyond numbers

Detalhes bibliográficos
Autor(a) principal: ARAÚJO, Evaldo Stanislau Affonso de
Data de Publicação: 2002
Outros Autores: CAVALHEIRO, Norma de Paula, LEITÃO, Regina Maria Cubero, TOSTA, Rose Aparecida Borges, BARONE, Antonio Alci
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/30605
Resumo: The analysis of 58 patients with chronic hepatitis C without cirrhosis and treated with interferon-alpha demonstrated that hepatitis C viral (HCV) load does not correlate with the histological evolution of the disease (p = 0.6559 for architectural alterations and p = 0.6271 for the histological activity index). Therefore, the use of viral RNA quantification as an evolutive predictor or determinant of the severity of hepatitis C is incorrect and of relative value. A review of the literature provided fundamental and interdependent HCV (genotype, heterogeneity and mutants, specific proteins), host (sex, age, weight, etc) and treatment variables (dosage, time of treatment, type of interferon) within the broader context of viral kinetics, interferon-mediated immunological response (in addition to natural immunity against HCV) and the role of interferon as a modulator of fibrogenesis. Therefore, viral load implies much more than numbers and the correct interpretation of these data should consider a broader context depending on multiple factors that are more complex than the simple value obtained upon quantification.
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spelling Hepatitis C viral load does not predict disease outcome: going beyond numbers A carga viral do vírus da hepatite C não prediz a evolução: indo além dos números Hepatitis CViral LoadInterferon The analysis of 58 patients with chronic hepatitis C without cirrhosis and treated with interferon-alpha demonstrated that hepatitis C viral (HCV) load does not correlate with the histological evolution of the disease (p = 0.6559 for architectural alterations and p = 0.6271 for the histological activity index). Therefore, the use of viral RNA quantification as an evolutive predictor or determinant of the severity of hepatitis C is incorrect and of relative value. A review of the literature provided fundamental and interdependent HCV (genotype, heterogeneity and mutants, specific proteins), host (sex, age, weight, etc) and treatment variables (dosage, time of treatment, type of interferon) within the broader context of viral kinetics, interferon-mediated immunological response (in addition to natural immunity against HCV) and the role of interferon as a modulator of fibrogenesis. Therefore, viral load implies much more than numbers and the correct interpretation of these data should consider a broader context depending on multiple factors that are more complex than the simple value obtained upon quantification. Através da análise de 58 pacientes tratados com Interferon Alfa em função de hepatite C crônica e sem cirrose, demonstramos que a carga viral do Vírus da Hepatite C (VHC) não se correlacionou com a evolução histológica da doença (p = 0,6559 para alterações arquiteturais e p = 0,6271 para o Índice de Atividade Histológica-IAH). Assim a utilização da quantificação do RNA viral como preditor evolutivo ou determinante da gravidade da hepatite C é incorreto e de valor relativo. Revisando o tema encontramos variáveis do VHC (genótipo, heterogeneidade e mutantes, proteínas específicas), do hospedeiro (sexo, idade, peso, etc) e dos medicamentos (posologia, tempo de tratamento, tipo de Interferon) fundamentais e interdependentes, inseridas no contexto mais amplo da cinética viral, da resposta imunológica mediada pelo Interferon (além da imunidade natural em resposta ao VHC) e do papel do Interferon como modulador da fibrogênese. Assim, há muito mais que números por trás da Carga Viral e sua correta interpretação deve ser feita considerando-se um horizonte mais amplo dependente de múltiplos fatores mais complexos que o simples valor obtido na quantificação Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/30605Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 No. 2 (2002); 71-78 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 Núm. 2 (2002); 71-78 Revista do Instituto de Medicina Tropical de São Paulo; v. 44 n. 2 (2002); 71-78 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/30605/32489Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessARAÚJO, Evaldo Stanislau Affonso deCAVALHEIRO, Norma de PaulaLEITÃO, Regina Maria CuberoTOSTA, Rose Aparecida BorgesBARONE, Antonio Alci2012-07-07T17:51:09Zoai:revistas.usp.br:article/30605Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:23.203363Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Hepatitis C viral load does not predict disease outcome: going beyond numbers
A carga viral do vírus da hepatite C não prediz a evolução: indo além dos números
title Hepatitis C viral load does not predict disease outcome: going beyond numbers
spellingShingle Hepatitis C viral load does not predict disease outcome: going beyond numbers
ARAÚJO, Evaldo Stanislau Affonso de
Hepatitis C
Viral Load
Interferon
title_short Hepatitis C viral load does not predict disease outcome: going beyond numbers
title_full Hepatitis C viral load does not predict disease outcome: going beyond numbers
title_fullStr Hepatitis C viral load does not predict disease outcome: going beyond numbers
title_full_unstemmed Hepatitis C viral load does not predict disease outcome: going beyond numbers
title_sort Hepatitis C viral load does not predict disease outcome: going beyond numbers
author ARAÚJO, Evaldo Stanislau Affonso de
author_facet ARAÚJO, Evaldo Stanislau Affonso de
CAVALHEIRO, Norma de Paula
LEITÃO, Regina Maria Cubero
TOSTA, Rose Aparecida Borges
BARONE, Antonio Alci
author_role author
author2 CAVALHEIRO, Norma de Paula
LEITÃO, Regina Maria Cubero
TOSTA, Rose Aparecida Borges
BARONE, Antonio Alci
author2_role author
author
author
author
dc.contributor.author.fl_str_mv ARAÚJO, Evaldo Stanislau Affonso de
CAVALHEIRO, Norma de Paula
LEITÃO, Regina Maria Cubero
TOSTA, Rose Aparecida Borges
BARONE, Antonio Alci
dc.subject.por.fl_str_mv Hepatitis C
Viral Load
Interferon
topic Hepatitis C
Viral Load
Interferon
description The analysis of 58 patients with chronic hepatitis C without cirrhosis and treated with interferon-alpha demonstrated that hepatitis C viral (HCV) load does not correlate with the histological evolution of the disease (p = 0.6559 for architectural alterations and p = 0.6271 for the histological activity index). Therefore, the use of viral RNA quantification as an evolutive predictor or determinant of the severity of hepatitis C is incorrect and of relative value. A review of the literature provided fundamental and interdependent HCV (genotype, heterogeneity and mutants, specific proteins), host (sex, age, weight, etc) and treatment variables (dosage, time of treatment, type of interferon) within the broader context of viral kinetics, interferon-mediated immunological response (in addition to natural immunity against HCV) and the role of interferon as a modulator of fibrogenesis. Therefore, viral load implies much more than numbers and the correct interpretation of these data should consider a broader context depending on multiple factors that are more complex than the simple value obtained upon quantification.
publishDate 2002
dc.date.none.fl_str_mv 2002-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/30605
url https://www.revistas.usp.br/rimtsp/article/view/30605
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/30605/32489
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 No. 2 (2002); 71-78
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 Núm. 2 (2002); 71-78
Revista do Instituto de Medicina Tropical de São Paulo; v. 44 n. 2 (2002); 71-78
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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