Considerations on Boron Neutron Capture Therapy
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/2439 |
Resumo: | This article reviews the radiotherapy technique called Boron Neutron Capture Therapy - BCNT. Herein, basic concepts in BNCT are addressed, particularly how BNCT has been used in the attempts of defeating multiform glioblastoma. The history of the BNCT trials in the 50’s and 60’s, including the previous trials at Brookhaven National Laboratory (BNL) and at the Massachusetts Institute of Technology (MIT) are presented. The Japanese experience in BNCT is discussed. Recently, clinical trials at the MIT and BNL have started, focusing multiform glioblastoma and peripheral and intracranial melanomas. Radiobiological and clinical data from Phase I trials on MIT are discussed. Considerations in how BNCT can be developed in Brazil are presented. It shows that Cf-252 Brachytherapy coupled with NCT may be a non-expensive, alternative way of addressing BNCT. |
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Considerations on Boron Neutron Capture TherapyConsiderações Sobre a Terapia de Captura de Nêutrons pelo BoroBNCTRadioterapiaGlioblastoma MultiformeBraquiterapiaBNCTRadiotherapyMultiform GlioblastomaBrachytherapyThis article reviews the radiotherapy technique called Boron Neutron Capture Therapy - BCNT. Herein, basic concepts in BNCT are addressed, particularly how BNCT has been used in the attempts of defeating multiform glioblastoma. The history of the BNCT trials in the 50’s and 60’s, including the previous trials at Brookhaven National Laboratory (BNL) and at the Massachusetts Institute of Technology (MIT) are presented. The Japanese experience in BNCT is discussed. Recently, clinical trials at the MIT and BNL have started, focusing multiform glioblastoma and peripheral and intracranial melanomas. Radiobiological and clinical data from Phase I trials on MIT are discussed. Considerations in how BNCT can be developed in Brazil are presented. It shows that Cf-252 Brachytherapy coupled with NCT may be a non-expensive, alternative way of addressing BNCT.Este artigo descreve a técnica de radioterapia chamada “Boron Neutron Capture Therapy” (BNCT), isto é, Terapia de Captura de Nêutrons por Boro. Serão abordados conceitos básicos em BNCT, em particular como esta técnica tem sido usada na tentativa de combater glioblastoma multiforme. Uma breve revisão histórica dos estudos clínicos feitos nas décadas de 50 e 60 será apresentada, incluindo resultados recentes do Laboratório Nacional de Brookhaven - BNL e do Instituto Tecnológico de Massachusetts - MIT. A experiência japonesa na área será comentada. Atualmente, novas ensaios clínicos no MIT e BNL foram iniciados, tentando obter a cura para o glioblastoma multiforme e melanoma intracranial periférico. Dados radiobiológicos e protocolos clínicos usados na Fase I do MIT serão apresentados. Considerações de como BNCT poderá ser aplicado no Brasil serão traçadas. O artigo aponta para a possibilidade de utilização da braquiterapia via Cf-252 acoplada à técnica de terapia de captura de nêutrons – NCT como uma alternativa simples e barata de implementação de BNCT no país.INCA2000-09-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/243910.32635/2176-9745.RBC.2000v46n3.2439Revista Brasileira de Cancerologia; Vol. 46 No. 3 (2000): July/Aug./Sept.; 283-92Revista Brasileira de Cancerologia; Vol. 46 Núm. 3 (2000): jul./ago./sept.; 283-92Revista Brasileira de Cancerologia; v. 46 n. 3 (2000): jul./ago./set.; 283-922176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2439/1518Campos, Tarcisio Passos Ribeiro de info:eu-repo/semantics/openAccess2021-11-29T20:43:40Zoai:rbc.inca.gov.br:article/2439Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:43:40Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Considerations on Boron Neutron Capture Therapy Considerações Sobre a Terapia de Captura de Nêutrons pelo Boro |
title |
Considerations on Boron Neutron Capture Therapy |
spellingShingle |
Considerations on Boron Neutron Capture Therapy Campos, Tarcisio Passos Ribeiro de BNCT Radioterapia Glioblastoma Multiforme Braquiterapia BNCT Radiotherapy Multiform Glioblastoma Brachytherapy |
title_short |
Considerations on Boron Neutron Capture Therapy |
title_full |
Considerations on Boron Neutron Capture Therapy |
title_fullStr |
Considerations on Boron Neutron Capture Therapy |
title_full_unstemmed |
Considerations on Boron Neutron Capture Therapy |
title_sort |
Considerations on Boron Neutron Capture Therapy |
author |
Campos, Tarcisio Passos Ribeiro de |
author_facet |
Campos, Tarcisio Passos Ribeiro de |
author_role |
author |
dc.contributor.author.fl_str_mv |
Campos, Tarcisio Passos Ribeiro de |
dc.subject.por.fl_str_mv |
BNCT Radioterapia Glioblastoma Multiforme Braquiterapia BNCT Radiotherapy Multiform Glioblastoma Brachytherapy |
topic |
BNCT Radioterapia Glioblastoma Multiforme Braquiterapia BNCT Radiotherapy Multiform Glioblastoma Brachytherapy |
description |
This article reviews the radiotherapy technique called Boron Neutron Capture Therapy - BCNT. Herein, basic concepts in BNCT are addressed, particularly how BNCT has been used in the attempts of defeating multiform glioblastoma. The history of the BNCT trials in the 50’s and 60’s, including the previous trials at Brookhaven National Laboratory (BNL) and at the Massachusetts Institute of Technology (MIT) are presented. The Japanese experience in BNCT is discussed. Recently, clinical trials at the MIT and BNL have started, focusing multiform glioblastoma and peripheral and intracranial melanomas. Radiobiological and clinical data from Phase I trials on MIT are discussed. Considerations in how BNCT can be developed in Brazil are presented. It shows that Cf-252 Brachytherapy coupled with NCT may be a non-expensive, alternative way of addressing BNCT. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-09-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2439 10.32635/2176-9745.RBC.2000v46n3.2439 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/2439 |
identifier_str_mv |
10.32635/2176-9745.RBC.2000v46n3.2439 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2439/1518 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 46 No. 3 (2000): July/Aug./Sept.; 283-92 Revista Brasileira de Cancerologia; Vol. 46 Núm. 3 (2000): jul./ago./sept.; 283-92 Revista Brasileira de Cancerologia; v. 46 n. 3 (2000): jul./ago./set.; 283-92 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042250190946304 |