Determinação de Receptores Hormonais em Lesões Benignas da Mama: Importância do Ciclo Menstrual

• Autor(a) principal: Kastner, Maria Rosa Q. Ubeda de
• Data de Publicação: 2023
• Outros Autores: Schettino, Ana Maria de Souza, Rabelo, Paulo Antonio de Paiva, Soraggi, Ricardo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Brasileira de Cancerologia (Online)
• Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/3268
• topic: Patologias Benignas de Mama; Receptores de Estrogênio e Progesterona; Método Citoquímico de Fluorescência; Ciclo Ovariano; Uso de Anovulatório; Benign Breast Pathology; Estrogen and Progesterone Receptor; Fluorescent Cytochemical Method; Ovarian Cycle; Oral Contraceptive

A fluorescent cytochemical assay for the estrogen and progesterone receptors (ER, PgR) has been used to analyze the receptor content in benign human mammary lesions. The findings in fibroadenoma and fibrocystic mastopathy were similar, and showed varying degree of estrogen - and progesterone-binding capacity of the cellular cytoplasm. The relationship between menstrual cycle and receptor levels was studied, knowing exactly the day of the beginning of the last menses and the regularity of the cycie. Our results suggest that the measurements in the early follicular phase, rather than in other phases, prevent the occurrence of false low ER and PgR levels. Moreover, previous oral contraceptive use was positively associated with a decreased frequency ofER and PgR levels.