Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations

Detalhes bibliográficos
Autor(a) principal: Paula, Adriano Augusto Peclat de
Data de Publicação: 2005
Outros Autores: Almeida Netto, Joaquim Caetano, Cruz, Aparecido Divino da, Freitas Júnior, Ruffo de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1952
Resumo: Penile carcinoma is a rare disease in developed countries and is frequently associated to high morbidity due to the sickness itself or due to its treatment. The social, economical and cultural profiles of the penile cancer patients make early diagnosis, treatment and follow-up. The use of several different staging systems and the lack of standard clinical approaches lead to bias in isolated evaluations, resulting in controversies over its proper management. There is no prospective study or randomized large trial that establishe secure approach to qualify all stages of the disease. Questions related to the management of the groin regions remain unsolved. In this way, patients with normal inguinal lymph nodes and at intermediate risk of occult groin disease deserve more attention. Several patients undergo unnecessary lymphadenectomy while others with occult inguinal disease remain under surveillance, delaying the ideal treatment. The development of imunohistochemical and molecular biology techniques allowed the identification of the probable epiteliotrophic virus role in etiology and prognosis of penile carcinoma. Multiinstitutional trials should be performed in order to identify the main variables for prognosis of penile carcinoma clearing, out the questions related to its best clinical management.
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spelling Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerationsCarcinoma epidermóide do pênis: considerações epidemiológicas, histopatológicas, influência viral e tratamento cirúrgicoNeoplasias penianasCarcinoma de células escamosasEtiologiaLinfadenectomiaEpidemiologiaMorbidadeCondutas terapêuticasPenile neoplasmsSquamous cell carcinomaEtiologyLymphadenectomyEpidemiologyMorbidityTherapeutical approachesPenile carcinoma is a rare disease in developed countries and is frequently associated to high morbidity due to the sickness itself or due to its treatment. The social, economical and cultural profiles of the penile cancer patients make early diagnosis, treatment and follow-up. The use of several different staging systems and the lack of standard clinical approaches lead to bias in isolated evaluations, resulting in controversies over its proper management. There is no prospective study or randomized large trial that establishe secure approach to qualify all stages of the disease. Questions related to the management of the groin regions remain unsolved. In this way, patients with normal inguinal lymph nodes and at intermediate risk of occult groin disease deserve more attention. Several patients undergo unnecessary lymphadenectomy while others with occult inguinal disease remain under surveillance, delaying the ideal treatment. The development of imunohistochemical and molecular biology techniques allowed the identification of the probable epiteliotrophic virus role in etiology and prognosis of penile carcinoma. Multiinstitutional trials should be performed in order to identify the main variables for prognosis of penile carcinoma clearing, out the questions related to its best clinical management.O carcinoma epidermóide do pênis, embora raro em países desenvolvidos, está associado à alta morbidade decorrente da própria doença e/ou de seu tratamento. O perfil social, econômico e cultural dos pacientes com carcinoma peniano dificulta o diagnóstico precoce, o tratamento e o seguimento dos enfermos. Os diferentes sistemas de estadiamento e a falta de padronização de condutas clínicas contribuem para vieses na avaliação individual dos casos e resultam em dificuldades na abordagem terapêutica. Não existem estudos prospectivos, randomizados e com amostragem suficiente que permitam estabelecer a conduta mais adequada nos diversos estádios da enfermidade. Algumas dúvidas referentes ao manejo das regiões inguinais permanecem ainda sem resposta. Neste contexto, merecem maior atenção os pacientes com ausência de linfonodos inguinais suspeitos, porém com tumores profundos e de alto grau histológico, o que caracteriza risco intermediário de doença oculta. Vários pacientes são submetidos à linfadenectomia desnecessariamente, enquanto uma parcela dos casos com doença inguinal oculta é colocada em vigilância, retardando-se o tratamento. Avanços nas técnicas de imunohistoquímica e biologia molecular têm permitido identificar o papel de vírus epiteliotrópicos, como o papilomavírus humano (HPV), na etiologia e prognóstico do carcinoma peniano. Estudos multicêntricos deveriam ser realizados na tentativa de identificar as principais variáveis de prognóstico do carcinoma epidermóide peniano, possibilitando assim uma melhor abordagem clínica destes tumores.INCA2005-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/195210.32635/2176-9745.RBC.2005v51n3.1952Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 243-252Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 243-252Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 243-2522176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1952/1186Paula, Adriano Augusto Peclat de Almeida Netto, Joaquim Caetano Cruz, Aparecido Divino da Freitas Júnior, Ruffo deinfo:eu-repo/semantics/openAccess2021-11-29T20:29:47Zoai:rbc.inca.gov.br:article/1952Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:29:47Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations
Carcinoma epidermóide do pênis: considerações epidemiológicas, histopatológicas, influência viral e tratamento cirúrgico
title Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations
spellingShingle Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations
Paula, Adriano Augusto Peclat de
Neoplasias penianas
Carcinoma de células escamosas
Etiologia
Linfadenectomia
Epidemiologia
Morbidade
Condutas terapêuticas
Penile neoplasms
Squamous cell carcinoma
Etiology
Lymphadenectomy
Epidemiology
Morbidity
Therapeutical approaches
title_short Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations
title_full Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations
title_fullStr Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations
title_full_unstemmed Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations
title_sort Penile squamous carcinoma: epidemiological, histopathological, viral influence and surgical considerations
author Paula, Adriano Augusto Peclat de
author_facet Paula, Adriano Augusto Peclat de
Almeida Netto, Joaquim Caetano
Cruz, Aparecido Divino da
Freitas Júnior, Ruffo de
author_role author
author2 Almeida Netto, Joaquim Caetano
Cruz, Aparecido Divino da
Freitas Júnior, Ruffo de
author2_role author
author
author
dc.contributor.author.fl_str_mv Paula, Adriano Augusto Peclat de
Almeida Netto, Joaquim Caetano
Cruz, Aparecido Divino da
Freitas Júnior, Ruffo de
dc.subject.por.fl_str_mv Neoplasias penianas
Carcinoma de células escamosas
Etiologia
Linfadenectomia
Epidemiologia
Morbidade
Condutas terapêuticas
Penile neoplasms
Squamous cell carcinoma
Etiology
Lymphadenectomy
Epidemiology
Morbidity
Therapeutical approaches
topic Neoplasias penianas
Carcinoma de células escamosas
Etiologia
Linfadenectomia
Epidemiologia
Morbidade
Condutas terapêuticas
Penile neoplasms
Squamous cell carcinoma
Etiology
Lymphadenectomy
Epidemiology
Morbidity
Therapeutical approaches
description Penile carcinoma is a rare disease in developed countries and is frequently associated to high morbidity due to the sickness itself or due to its treatment. The social, economical and cultural profiles of the penile cancer patients make early diagnosis, treatment and follow-up. The use of several different staging systems and the lack of standard clinical approaches lead to bias in isolated evaluations, resulting in controversies over its proper management. There is no prospective study or randomized large trial that establishe secure approach to qualify all stages of the disease. Questions related to the management of the groin regions remain unsolved. In this way, patients with normal inguinal lymph nodes and at intermediate risk of occult groin disease deserve more attention. Several patients undergo unnecessary lymphadenectomy while others with occult inguinal disease remain under surveillance, delaying the ideal treatment. The development of imunohistochemical and molecular biology techniques allowed the identification of the probable epiteliotrophic virus role in etiology and prognosis of penile carcinoma. Multiinstitutional trials should be performed in order to identify the main variables for prognosis of penile carcinoma clearing, out the questions related to its best clinical management.
publishDate 2005
dc.date.none.fl_str_mv 2005-09-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
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dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1952
10.32635/2176-9745.RBC.2005v51n3.1952
url https://rbc.inca.gov.br/index.php/revista/article/view/1952
identifier_str_mv 10.32635/2176-9745.RBC.2005v51n3.1952
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1952/1186
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 243-252
Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 243-252
Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 243-252
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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