Tratamento da leucemia linfoblástica do adulto: resultados do protocolo de alto risco do GBTLI85 comparados retrospectivamente com um esquema convencional

• Autor(a) principal: Fenelon, Alexandre José Silva
• Data de Publicação: 2023
• Outros Autores: Pinto, Carlos Frederico Distefano, Moreira, Wagner Brant, Cabral Filho, Sebastião, Brandão, Eduardo Carvalho, Lopes, Eugênio Baumgratz, Vieira, Maria Do Carmo Lima, Álvares, Maria Nunes, Teixeira, João Augusto Moreira, Nascimento, Eduardo, Novaes, Nedda Maria Vasconcelos
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Brasileira de Cancerologia (Online)
• Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2973
• topic: Leucemia Linfoblástica Aguda; Quimioterapia; Acute Lymphoblastic Leucemia; Chemotherapy

In a group of 43 patients aged over 15 years with a diagnosis of acute lymphoblastic leucemia (ALL), there were compared retrospectively the results of the modified Stein protocol (group 1) and the GBTLI85 (group 2) regimen, a intensive protocol developed for high risk childhood ALL The complete response (CR) rate was betterin group2 (54% vs. 19%, p = 0.01), but this difference had lost statistical significance after a muitivariate analysis. Once a CR was obtained, the four years disease-free survival was 25% for both groups, but in group 1 the relapse rate was 75% and in group 2, the relapse rate was 41 % and 33% of the responders died from toxicity of post remission therapy. The four years failure free survival (FFS) was 4%, for group 1 (95%, confidence interval 0-13%,) and 13% for group 2 (95% confidence interval 0-27%). In our patients, an intensive therapy based in the high risk chilhoodprotocois had failed in improving the cure rates and was associated to prohibitive toxicity rates. New approaches based in risk grouping for adult ALL must be found.