The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Pereira, Andresa Costa
Data de Publicação: 2006
Outros Autores: Carmo, Elaine Dias do, Silveira, Vanessa Ávila Sarmento, Amadei, Susana Ungaro, Rosa, Luiz Eduardo Blumer
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1874
Resumo: In squamous cell carcinoma, invasion and metastasis are regulated by a complex system characterized by neoplastic and stromal cell interaction. These processes are a consequence of basement membrane and extracellular matrix degradation by various enzymes, mainly matrix metalloproteinases (MMPs). The latter are zinc-dependent enzymes, with low expression in normal tissues but over-expressed in malignant neoplasms. Of all MMPs, MMP-2 and MMP-9 (gelatinases) have been consistently associated with aggressiveness, metastatic potential, and poor prognosis in malignant neoplasms. Gelatinases show a fundamental function in carcinogenesis, since they degrade type IV collagen, an important basement membrane component, participating in stromal and vascular invasion, a fundamental process related to metastasis. This paper aimed to review general aspects of MMPs, especially MMP-2 and MMP-9, and their relationship to the development of squamous cell carcinoma, with a view towards their preventive and therapeutic possibilities.
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spelling The role of MMP-2 and MMP-9 in the development of squamous cell carcinomaO papel das MMP-2 e -9 no desenvolvimento do carcinoma epidermóideCarcinoma de células escamosasNeoplasiasMetástase neoplásicaGelatinase AGelatinase BSquamous cell carcinomaCancerMetastasisMMP-2MMP-9In squamous cell carcinoma, invasion and metastasis are regulated by a complex system characterized by neoplastic and stromal cell interaction. These processes are a consequence of basement membrane and extracellular matrix degradation by various enzymes, mainly matrix metalloproteinases (MMPs). The latter are zinc-dependent enzymes, with low expression in normal tissues but over-expressed in malignant neoplasms. Of all MMPs, MMP-2 and MMP-9 (gelatinases) have been consistently associated with aggressiveness, metastatic potential, and poor prognosis in malignant neoplasms. Gelatinases show a fundamental function in carcinogenesis, since they degrade type IV collagen, an important basement membrane component, participating in stromal and vascular invasion, a fundamental process related to metastasis. This paper aimed to review general aspects of MMPs, especially MMP-2 and MMP-9, and their relationship to the development of squamous cell carcinoma, with a view towards their preventive and therapeutic possibilities.No carcinoma epidermóide, os processos de invasão e metástase são regulados por um complexo sistema dependente da interação entre as células neoplásicas e as células estromais hospedeiras. Esses processos ocorrem como conseqüência à degradação da membrana basal e da matriz extracelular por diversas enzimas, dentre as quais as metaloproteinases da matriz (MMP) apresentam destaque. Essas são enzimas zinco-dependentes, pouco expressas em tecidos normais e substancialmente aumentadas na maioria das neoplasias malignas. Dentre todas as MMP conhecidas, as MMP-2 e -9 (gelatinases) têm sido consistentemente associadas com a agressividade, o potencial metastático e o prognóstico desfavorável das neoplasias malignas. As gelatinases desempenham um papel fundamental no processo da carcinogênese, pois degradam principalmente colágeno tipo IV, componente fundamental da membrana basal, participando do processo de invasão do estroma e invasão dos vasos sangüíneos, processo fundamental para a metástase. Portanto, o objetivo desse trabalho foi apresentar uma revisão dos aspectos gerais das MMP, abordando principalmente as MMP-2 e -9, bem como suas relações com o desenvolvimento do carcinoma epidermóide, buscando as possibilidades de prevenção e tratamento.INCA2006-09-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/187410.32635/2176-9745.RBC.2006v52n3.1874Revista Brasileira de Cancerologia; Vol. 52 No. 3 (2006): July/Aug./Sept.; 257-262Revista Brasileira de Cancerologia; Vol. 52 Núm. 3 (2006): jul./ago./sept.; 257-262Revista Brasileira de Cancerologia; v. 52 n. 3 (2006): jul./ago./set.; 257-2622176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1874/1137Pereira, Andresa Costa Carmo, Elaine Dias do Silveira, Vanessa Ávila Sarmento Amadei, Susana Ungaro Rosa, Luiz Eduardo Blumer info:eu-repo/semantics/openAccess2021-11-29T20:27:40Zoai:rbc.inca.gov.br:article/1874Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:27:40Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma
O papel das MMP-2 e -9 no desenvolvimento do carcinoma epidermóide
title The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma
spellingShingle The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma
Pereira, Andresa Costa
Carcinoma de células escamosas
Neoplasias
Metástase neoplásica
Gelatinase A
Gelatinase B
Squamous cell carcinoma
Cancer
Metastasis
MMP-2
MMP-9
title_short The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma
title_full The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma
title_fullStr The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma
title_full_unstemmed The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma
title_sort The role of MMP-2 and MMP-9 in the development of squamous cell carcinoma
author Pereira, Andresa Costa
author_facet Pereira, Andresa Costa
Carmo, Elaine Dias do
Silveira, Vanessa Ávila Sarmento
Amadei, Susana Ungaro
Rosa, Luiz Eduardo Blumer
author_role author
author2 Carmo, Elaine Dias do
Silveira, Vanessa Ávila Sarmento
Amadei, Susana Ungaro
Rosa, Luiz Eduardo Blumer
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Andresa Costa
Carmo, Elaine Dias do
Silveira, Vanessa Ávila Sarmento
Amadei, Susana Ungaro
Rosa, Luiz Eduardo Blumer
dc.subject.por.fl_str_mv Carcinoma de células escamosas
Neoplasias
Metástase neoplásica
Gelatinase A
Gelatinase B
Squamous cell carcinoma
Cancer
Metastasis
MMP-2
MMP-9
topic Carcinoma de células escamosas
Neoplasias
Metástase neoplásica
Gelatinase A
Gelatinase B
Squamous cell carcinoma
Cancer
Metastasis
MMP-2
MMP-9
description In squamous cell carcinoma, invasion and metastasis are regulated by a complex system characterized by neoplastic and stromal cell interaction. These processes are a consequence of basement membrane and extracellular matrix degradation by various enzymes, mainly matrix metalloproteinases (MMPs). The latter are zinc-dependent enzymes, with low expression in normal tissues but over-expressed in malignant neoplasms. Of all MMPs, MMP-2 and MMP-9 (gelatinases) have been consistently associated with aggressiveness, metastatic potential, and poor prognosis in malignant neoplasms. Gelatinases show a fundamental function in carcinogenesis, since they degrade type IV collagen, an important basement membrane component, participating in stromal and vascular invasion, a fundamental process related to metastasis. This paper aimed to review general aspects of MMPs, especially MMP-2 and MMP-9, and their relationship to the development of squamous cell carcinoma, with a view towards their preventive and therapeutic possibilities.
publishDate 2006
dc.date.none.fl_str_mv 2006-09-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1874
10.32635/2176-9745.RBC.2006v52n3.1874
url https://rbc.inca.gov.br/index.php/revista/article/view/1874
identifier_str_mv 10.32635/2176-9745.RBC.2006v52n3.1874
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1874/1137
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 52 No. 3 (2006): July/Aug./Sept.; 257-262
Revista Brasileira de Cancerologia; Vol. 52 Núm. 3 (2006): jul./ago./sept.; 257-262
Revista Brasileira de Cancerologia; v. 52 n. 3 (2006): jul./ago./set.; 257-262
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
_version_ 1797042248749154304

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