Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review

Detalhes bibliográficos
Autor(a) principal: Pereira, Ney Moura Lemos
Data de Publicação: 2021
Outros Autores: Lemos, Telma Maria Araújo Moura, Martins, Rand Randall, Costa, Roberto Fernandes da, Raffin, Fernanda Nervo
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1347
Resumo: Introduction: Gastric cancer is the fifth most common malignancy worldwide. It is the most frequent malignant tumor in Asia, especially in China. Esophageal carcinoma is one of the more aggressive types of malignant tumor. Multimodal treatments, including neoadjuvant chemotherapy and chemoradiotherapy are utilized and can cause fatigue, vomiting, diarrhea, skin changes, cachexia, and peripheral neuropathy, which can be important side effects for many patients undergoing their treatments. Objective: Carry out a systematic review on the management and prevention of adverse reactions of antineoplastic chemotherapy with platinum in patients with esophageal cancer and gastric tumor. Method: To select the articles, a search was conducted in three databases: MEDLINE/PubMed, Cochrane and Embase, with the PICO strategy, alternating between MeSH/DeCS descriptors and Boolean operators. Results: 455 titles were found, of which, after using the PRISMA guideline, 15 articles remained for systematic review, addressing the management and prevention of nausea and vomiting, peripheral neuropathy, cachexia, magnesium supplementation, treatment of depression and general toxicity. Conclusion: The greatest number of studies addressing the management and prevention of the symptoms of nausea, vomits, neuropathy and hypomagnesemia were found, and it was possible to identify some suggestions of conducts to treat these reactions. More studies are necessary for the other reactions encountered, mainly in the cases of gastric and esophageal cancer.
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spelling Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature ReviewManejo y Prevención de Reacciones Adversas a la Quimioterapia Antineoplásica con Platino en Pacientes con Cánceres de Esófago y Gástrico: Revisión Sistemática de la LiteraturaManejo e Prevenção de Reações Adversas da Quimioterapia Antineoplásica com Platinas em Pacientes com Cânceres Esofágico e Gástrico: Revisão Sistemática da LiteraturaNeoplasias Gástricas'Neoplasias EsofágicasEfeitos Colaterais e Reações Adversas Relacionados a MedicamentosCompostos de PlatinaAntineoplásicosStomach NeoplasmsEsophageal NeoplasmsDrug-Related Side Effects and Adverse ReactionsPlatinum CompoundsAntineoplastic AgentsNeoplasias GástricasNeoplasias EsofágicasEfectos Colaterales y Reacciones Adversas Relacionados con MedicamentosCompuestos de PlatinoAntineoplásicosIntroduction: Gastric cancer is the fifth most common malignancy worldwide. It is the most frequent malignant tumor in Asia, especially in China. Esophageal carcinoma is one of the more aggressive types of malignant tumor. Multimodal treatments, including neoadjuvant chemotherapy and chemoradiotherapy are utilized and can cause fatigue, vomiting, diarrhea, skin changes, cachexia, and peripheral neuropathy, which can be important side effects for many patients undergoing their treatments. Objective: Carry out a systematic review on the management and prevention of adverse reactions of antineoplastic chemotherapy with platinum in patients with esophageal cancer and gastric tumor. Method: To select the articles, a search was conducted in three databases: MEDLINE/PubMed, Cochrane and Embase, with the PICO strategy, alternating between MeSH/DeCS descriptors and Boolean operators. Results: 455 titles were found, of which, after using the PRISMA guideline, 15 articles remained for systematic review, addressing the management and prevention of nausea and vomiting, peripheral neuropathy, cachexia, magnesium supplementation, treatment of depression and general toxicity. Conclusion: The greatest number of studies addressing the management and prevention of the symptoms of nausea, vomits, neuropathy and hypomagnesemia were found, and it was possible to identify some suggestions of conducts to treat these reactions. More studies are necessary for the other reactions encountered, mainly in the cases of gastric and esophageal cancer.Introducción: El cáncer gástrico es la quinta neoplasia maligna más común en todo el mundo. Es el tumor maligno más común en Asia, especialmente en China. El carcinoma de esófago es uno de los tipos de tumores malignos más agresivos. Se utilizan tratamientos multimodales, que incluyen quimioterapia neoadyuvante y quimiorradioterapia que pueden provocar: fatiga, vómitos, diarrea, alteraciones cutáneas, caquexia y neuropatía periférica, que pueden ser efectos secundarios importantes para muchos pacientes sometidos a sus tratamientos. Objetivo: Realizar una revisión sistemática sobre el manejo y prevención de reacciones adversas de la quimioterapia antineoplásica con platino en pacientes con cáncer de esófago y tumor gástrico. Método: Para la selección de los artículos se realizó una búsqueda en tres bases de datos: MEDLINE/PubMed, Cochrane y Embase, con la estrategia PICO, variando los descriptores MeSH/DeCS y operadores booleanos. Resultados: Se encontraron 455 títulos, de los cuales, luego de utilizar la guía PRISMA, quedaron 15 artículos para revisión sistemática, que abordaron el manejo y prevención de náuseas y vómitos, neuropatía periférica, caquexia, suplementación con magnesio, tratamiento de la depresión y toxicidad general. Conclusión: Se verifico que náuseas, vómitos, neuropatía e hipomagnesemia tuvieron un mayor número de estudios relacionados con el manejo y prevención de los síntomas, en los cuales fue posible identificar algunas sugerencias de conducta con mayor evidencia de estas reacciones. Las otras reacciones encontradas aún necesitan más estudios, especialmente en casos de cánceres gástrico y de esófago.Introdução: O câncer gástrico é a quinta doença maligna mais comum em todo o mundo. Trata-se do tumor maligno mais incidente na Ásia, especialmente na China. O carcinoma esofágico é um dos tipos mais agressivos de tumor maligno. Os tratamentos multimodais, incluindo quimioterapia neoadjuvante e quimiorradioterapia, são utilizados e podem causar fadiga, vômito, diarreia, alterações cutâneas, caquexia e neuropatia periférica, que podem ser efeitos colaterais importantes para muitos pacientes que realizam seus tratamentos. Objetivo: Realizar uma revisão sistemática sobre o manejo e a prevenção de reações adversas da quimioterapia antineoplásica com platinas em pacientes com câncer esofágico e tumor gástrico. Método: Para seleção dos artigos, foi realizada a busca em três bases de dados: MEDLINE/PubMed, Cochrane e Embase, com a estratégia PICO, variando os descritores MeSH/DeCS e operadores booleanos. Resultados: Foram encontrados 455 títulos, dos quais, após utilizar a diretriz PRISMA, restaram 15 artigos para a revisão sistemática, que abordavam o manejo e a prevenção de náusea e vômitos, neuropatia periférica, caquexia, suplementação de magnésio, tratamento de depressão e toxicidade geral. Conclusão: Verificou-se que náuseas, vômitos, neuropatia e hipomagnesemia tiveram maior número de estudos relacionados ao manejo e à prevenção desses sintomas, nos quais identificaram-se algumas sugestões de condutas com maior evidência para essas reações. As demais reações encontradas ainda carecem de mais estudos, principalmente nos casos de cânceres gástrico e esofágico.INCA2021-11-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/134710.32635/2176-9745.RBC.2021v67n4.1347Revista Brasileira de Cancerologia; Vol. 67 No. 4 (2021): Oct./Nov./Dec.; e-091347Revista Brasileira de Cancerologia; Vol. 67 Núm. 4 (2021): oct./nov./dic.; e-091347Revista Brasileira de Cancerologia; v. 67 n. 4 (2021): out./nov./dez.; e-0913472176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/1347/1529https://rbc.inca.gov.br/index.php/revista/article/view/1347/1553Copyright (c) 2021 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessPereira, Ney Moura Lemos Lemos, Telma Maria Araújo Moura Martins, Rand Randall Costa, Roberto Fernandes da Raffin, Fernanda Nervo 2021-12-16T13:56:24Zoai:rbc.inca.gov.br:article/1347Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-12-16T13:56:24Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review
Manejo y Prevención de Reacciones Adversas a la Quimioterapia Antineoplásica con Platino en Pacientes con Cánceres de Esófago y Gástrico: Revisión Sistemática de la Literatura
Manejo e Prevenção de Reações Adversas da Quimioterapia Antineoplásica com Platinas em Pacientes com Cânceres Esofágico e Gástrico: Revisão Sistemática da Literatura
title Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review
spellingShingle Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review
Pereira, Ney Moura Lemos
Neoplasias Gástricas'
Neoplasias Esofágicas
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Compostos de Platina
Antineoplásicos
Stomach Neoplasms
Esophageal Neoplasms
Drug-Related Side Effects and Adverse Reactions
Platinum Compounds
Antineoplastic Agents
Neoplasias Gástricas
Neoplasias Esofágicas
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
Compuestos de Platino
Antineoplásicos
title_short Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review
title_full Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review
title_fullStr Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review
title_full_unstemmed Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review
title_sort Management and Prevention of Adverse Reactions to Platinum Antineoplastic Chemotherapy in Patients with Esophageal and Gastric Cancer: Systematic Literature Review
author Pereira, Ney Moura Lemos
author_facet Pereira, Ney Moura Lemos
Lemos, Telma Maria Araújo Moura
Martins, Rand Randall
Costa, Roberto Fernandes da
Raffin, Fernanda Nervo
author_role author
author2 Lemos, Telma Maria Araújo Moura
Martins, Rand Randall
Costa, Roberto Fernandes da
Raffin, Fernanda Nervo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Ney Moura Lemos
Lemos, Telma Maria Araújo Moura
Martins, Rand Randall
Costa, Roberto Fernandes da
Raffin, Fernanda Nervo
dc.subject.por.fl_str_mv Neoplasias Gástricas'
Neoplasias Esofágicas
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Compostos de Platina
Antineoplásicos
Stomach Neoplasms
Esophageal Neoplasms
Drug-Related Side Effects and Adverse Reactions
Platinum Compounds
Antineoplastic Agents
Neoplasias Gástricas
Neoplasias Esofágicas
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
Compuestos de Platino
Antineoplásicos
topic Neoplasias Gástricas'
Neoplasias Esofágicas
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Compostos de Platina
Antineoplásicos
Stomach Neoplasms
Esophageal Neoplasms
Drug-Related Side Effects and Adverse Reactions
Platinum Compounds
Antineoplastic Agents
Neoplasias Gástricas
Neoplasias Esofágicas
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
Compuestos de Platino
Antineoplásicos
description Introduction: Gastric cancer is the fifth most common malignancy worldwide. It is the most frequent malignant tumor in Asia, especially in China. Esophageal carcinoma is one of the more aggressive types of malignant tumor. Multimodal treatments, including neoadjuvant chemotherapy and chemoradiotherapy are utilized and can cause fatigue, vomiting, diarrhea, skin changes, cachexia, and peripheral neuropathy, which can be important side effects for many patients undergoing their treatments. Objective: Carry out a systematic review on the management and prevention of adverse reactions of antineoplastic chemotherapy with platinum in patients with esophageal cancer and gastric tumor. Method: To select the articles, a search was conducted in three databases: MEDLINE/PubMed, Cochrane and Embase, with the PICO strategy, alternating between MeSH/DeCS descriptors and Boolean operators. Results: 455 titles were found, of which, after using the PRISMA guideline, 15 articles remained for systematic review, addressing the management and prevention of nausea and vomiting, peripheral neuropathy, cachexia, magnesium supplementation, treatment of depression and general toxicity. Conclusion: The greatest number of studies addressing the management and prevention of the symptoms of nausea, vomits, neuropathy and hypomagnesemia were found, and it was possible to identify some suggestions of conducts to treat these reactions. More studies are necessary for the other reactions encountered, mainly in the cases of gastric and esophageal cancer.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1347
10.32635/2176-9745.RBC.2021v67n4.1347
url https://rbc.inca.gov.br/index.php/revista/article/view/1347
identifier_str_mv 10.32635/2176-9745.RBC.2021v67n4.1347
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1347/1529
https://rbc.inca.gov.br/index.php/revista/article/view/1347/1553
dc.rights.driver.fl_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 67 No. 4 (2021): Oct./Nov./Dec.; e-091347
Revista Brasileira de Cancerologia; Vol. 67 Núm. 4 (2021): oct./nov./dic.; e-091347
Revista Brasileira de Cancerologia; v. 67 n. 4 (2021): out./nov./dez.; e-091347
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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