Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por eng |
| Título da fonte: | Revista Brasileira de Cancerologia (Online) |
| Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/764 |
Resumo: | Introduction: Antineoplastic drug manipulation for dose adjustment, such as tablet splitting, is standard in acute leukemia treatment for children and adolescents. Objective: To identify the frequency and describe the practice of household splitting of antineoplastic tablet for oral treatment of children and adolescents with acute leukemias in the maintenance phase. Method: Crosssectional descriptive study performed in a public health system hospital from Distrito Federal (Brazil) with specialized pediatric assistance. Children and teenagers between 1 and 18 years old, diagnosed with acute leukemia and in treatment maintenance phase during the study period were included. A semi-structured questionnaire was applied to the main responsible for administering oral chemotherapy drugs, which could be the caregiver or the child/adolescent themselves. Sociodemographic variables of patients and caregivers and variables on the practice of splitting antineoplastic drugs at home were collected. Results: All 48 interviewees in the study period reported having split antineoplastic tablets during the treatment for acute leukemias, such as mercaptopurine (n = 45 [93.75%]) and thioguanine (n= 3 [6.25%]). Conclusion: The splitting of antineoplastic tablets was a unanimous practice due to the reported need to adjust the individual dose for acute leukemia treatment in children and adolescents, considering the unavailability of adequate formulations. The results reinforce the need for splitting to be standardized and performed in a way that minimizes risks and ensures safety for patients and their caregivers. |
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Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and AdolescentsPartición de Comprimidos Antineoplásicos Empleados en el Tratamiento de Leucemias Agudas en Niños y AdolescentesPartição de Comprimidos Antineoplásicos Utilizados no Tratamento de Leucemias Agudas em Crianças e AdolescentesAntineoplásicos/administração & dosagemComprimidos/administração & dosagemLeucemiaCriançaAdolescenteAntineoplastic Agents/administration & dosageTablets/ administration & dosageLeukemiaChildAdolescentAntineoplásicos/administración & dosificaciónComprimidos/ administración & dosificaciónLeucemiaNiñoAdolescenteIntroduction: Antineoplastic drug manipulation for dose adjustment, such as tablet splitting, is standard in acute leukemia treatment for children and adolescents. Objective: To identify the frequency and describe the practice of household splitting of antineoplastic tablet for oral treatment of children and adolescents with acute leukemias in the maintenance phase. Method: Crosssectional descriptive study performed in a public health system hospital from Distrito Federal (Brazil) with specialized pediatric assistance. Children and teenagers between 1 and 18 years old, diagnosed with acute leukemia and in treatment maintenance phase during the study period were included. A semi-structured questionnaire was applied to the main responsible for administering oral chemotherapy drugs, which could be the caregiver or the child/adolescent themselves. Sociodemographic variables of patients and caregivers and variables on the practice of splitting antineoplastic drugs at home were collected. Results: All 48 interviewees in the study period reported having split antineoplastic tablets during the treatment for acute leukemias, such as mercaptopurine (n = 45 [93.75%]) and thioguanine (n= 3 [6.25%]). Conclusion: The splitting of antineoplastic tablets was a unanimous practice due to the reported need to adjust the individual dose for acute leukemia treatment in children and adolescents, considering the unavailability of adequate formulations. The results reinforce the need for splitting to be standardized and performed in a way that minimizes risks and ensures safety for patients and their caregivers.Introducción: La manipulación de fármacos antineoplásicos para el ajuste de dosis, como las particiones de comprimidos, es frecuente en el tratamiento de las leucemias agudas en niños y jóvenes. Objetivo: Identificar la frecuencia y describir la práctica de la división domiciliaria de medicamentos antineoplásicos utilizados en el tratamiento oral de niños y adolescentes con leucemias agudas en la fase de mantenimiento. Método: Se trata de un estudio transversal descriptivo realizado en un hospital de la red de salud pública del Distrito Federal (Brasil) con asistencia especializada en pediatría. El estudio incluyo a niños y jóvenes de entre 1 y 18 años de edad diagnosticados con leucemia aguda y en fase de mantenimiento del tratamiento en el periodo del estudio. Se aplicó un cuestionario semiestructurado a la persona principal responsable de la administración de fármacos quimioterapéuticos por vía oral, que puede ser el cuidador o el propio niño/joven. Fueron colectadas variables sociodemográficas de los pacientes y cuidadores y variables sobre la práctica de la división de los medicamentos antineoplásicos en domicilios. Resultados: Los 48 entrevistados en el periodo de estudio informaron haber roto las pastillas antineoplásicas durante el tratamiento de la leucemia aguda, siendo estas mercaptopurina (n=45 [93,75%]) y tioguanina (n=3 [6,25%]). Conclusión: La partición de comprimidos antineoplásicos fue una práctica unánime debido a la necesidad mencionada de ajustar la dosis individual para el tratamiento de las leucemias agudas de niños y adolescentes, considerando la falta de formulaciones apropiadas. Los resultados refuerzan la necesidad de estandarizar y realizar la partición para minimizar los riesgos y garantizar la seguridad de los niños, jóvenes y sus cuidadores.Introdução: A manipulação de antineoplásicos para ajuste de dose, como partição de comprimidos, e comum no tratamento de leucemias agudas de crianças e adolescentes. Objetivo: Identificar a frequência e descrever a pratica da partição domiciliar de comprimidos antineoplásicos utilizados no tratamento oral de crianças e adolescentes com leucemias agudas na fase de manutenção. Método: Trata-se de um estudo transversal descritivo, realizado em um hospital pertencente a rede de saúde publica do Distrito Federal com assistência especializada em pediatria. Foram incluídos no estudo crianças e adolescentes entre 1 e 18 anos, diagnosticados com leucemias agudas e em fase de manutenção do tratamento no período de estudo. Foi aplicado um questionário semiestruturado ao responsável principal pela administração dos medicamentos quimioterápicos via oral, podendo ser o cuidador ou a própria criança/adolescente. Foram coletadas variáveis sociodemográficas dos pacientes e cuidadores e variáveis sobre a pratica de partição de medicamentos antineoplásicos no domicilio. Resultados: Todos os 48 entrevistados no período do estudo relataram ter partido comprimidos antineoplásicos ao longo do tratamento de leucemias agudas, sendo estes mercaptopurina (n=45 [93,75%]) e tioguanina (n=3 [6,25%]). Conclusão: A partição de comprimidos antineoplásicos foi uma pratica unanime em virtude da necessidade referida de ajuste de dose individual para o tratamento de leucemias agudas de crianças e adolescentes, considerando a indisponibilidade de formulações adequadas. Os resultados reforçam a necessidade de a partição ser uniformizada e realizada de maneira a minimizar os riscos e a garantir a segurança para as crianças e adolescentes e seus cuidadores.INCA2020-04-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/76410.32635/2176-9745.RBC.2020v66n2.764Revista Brasileira de Cancerologia; Vol. 66 No. 2 (2020): Apr./May/June; e-01764Revista Brasileira de Cancerologia; Vol. 66 Núm. 2 (2020): abr./mayo/jun.; e-01764Revista Brasileira de Cancerologia; v. 66 n. 2 (2020): abr./maio/jun.; e-017642176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/764/571https://rbc.inca.gov.br/index.php/revista/article/view/764/735Copyright (c) 2020 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessTessmann, LuizaMedeiros-Souza, PatríciaMartins Cordoba, José CarlosUrruth Leão Tavares, NoemiaMacedo Abílio, VictóriaOliveira de Matos, DafnyQuezado Soares Magalhães, Isis Maria2021-11-29T20:02:51Zoai:rbc.inca.gov.br:article/764Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:02:51Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
| dc.title.none.fl_str_mv |
Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents Partición de Comprimidos Antineoplásicos Empleados en el Tratamiento de Leucemias Agudas en Niños y Adolescentes Partição de Comprimidos Antineoplásicos Utilizados no Tratamento de Leucemias Agudas em Crianças e Adolescentes |
| title |
Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents |
| spellingShingle |
Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents Tessmann, Luiza Antineoplásicos/administração & dosagem Comprimidos/administração & dosagem Leucemia Criança Adolescente Antineoplastic Agents/administration & dosage Tablets/ administration & dosage Leukemia Child Adolescent Antineoplásicos/administración & dosificación Comprimidos/ administración & dosificación Leucemia Niño Adolescente |
| title_short |
Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents |
| title_full |
Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents |
| title_fullStr |
Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents |
| title_full_unstemmed |
Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents |
| title_sort |
Splitting of Antineoplastic Tablets Used in Acute Leukemias Treatment in Children and Adolescents |
| author |
Tessmann, Luiza |
| author_facet |
Tessmann, Luiza Medeiros-Souza, Patrícia Martins Cordoba, José Carlos Urruth Leão Tavares, Noemia Macedo Abílio, Victória Oliveira de Matos, Dafny Quezado Soares Magalhães, Isis Maria |
| author_role |
author |
| author2 |
Medeiros-Souza, Patrícia Martins Cordoba, José Carlos Urruth Leão Tavares, Noemia Macedo Abílio, Victória Oliveira de Matos, Dafny Quezado Soares Magalhães, Isis Maria |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Tessmann, Luiza Medeiros-Souza, Patrícia Martins Cordoba, José Carlos Urruth Leão Tavares, Noemia Macedo Abílio, Victória Oliveira de Matos, Dafny Quezado Soares Magalhães, Isis Maria |
| dc.subject.por.fl_str_mv |
Antineoplásicos/administração & dosagem Comprimidos/administração & dosagem Leucemia Criança Adolescente Antineoplastic Agents/administration & dosage Tablets/ administration & dosage Leukemia Child Adolescent Antineoplásicos/administración & dosificación Comprimidos/ administración & dosificación Leucemia Niño Adolescente |
| topic |
Antineoplásicos/administração & dosagem Comprimidos/administração & dosagem Leucemia Criança Adolescente Antineoplastic Agents/administration & dosage Tablets/ administration & dosage Leukemia Child Adolescent Antineoplásicos/administración & dosificación Comprimidos/ administración & dosificación Leucemia Niño Adolescente |
| description |
Introduction: Antineoplastic drug manipulation for dose adjustment, such as tablet splitting, is standard in acute leukemia treatment for children and adolescents. Objective: To identify the frequency and describe the practice of household splitting of antineoplastic tablet for oral treatment of children and adolescents with acute leukemias in the maintenance phase. Method: Crosssectional descriptive study performed in a public health system hospital from Distrito Federal (Brazil) with specialized pediatric assistance. Children and teenagers between 1 and 18 years old, diagnosed with acute leukemia and in treatment maintenance phase during the study period were included. A semi-structured questionnaire was applied to the main responsible for administering oral chemotherapy drugs, which could be the caregiver or the child/adolescent themselves. Sociodemographic variables of patients and caregivers and variables on the practice of splitting antineoplastic drugs at home were collected. Results: All 48 interviewees in the study period reported having split antineoplastic tablets during the treatment for acute leukemias, such as mercaptopurine (n = 45 [93.75%]) and thioguanine (n= 3 [6.25%]). Conclusion: The splitting of antineoplastic tablets was a unanimous practice due to the reported need to adjust the individual dose for acute leukemia treatment in children and adolescents, considering the unavailability of adequate formulations. The results reinforce the need for splitting to be standardized and performed in a way that minimizes risks and ensures safety for patients and their caregivers. |
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2020 |
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2020-04-02 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
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article |
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publishedVersion |
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https://rbc.inca.gov.br/index.php/revista/article/view/764 10.32635/2176-9745.RBC.2020v66n2.764 |
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https://rbc.inca.gov.br/index.php/revista/article/view/764 |
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10.32635/2176-9745.RBC.2020v66n2.764 |
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por eng |
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https://rbc.inca.gov.br/index.php/revista/article/view/764/571 https://rbc.inca.gov.br/index.php/revista/article/view/764/735 |
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Copyright (c) 2020 Revista Brasileira de Cancerologia |
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openAccess |
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application/pdf application/pdf |
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INCA |
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Revista Brasileira de Cancerologia; Vol. 66 No. 2 (2020): Apr./May/June; e-01764 Revista Brasileira de Cancerologia; Vol. 66 Núm. 2 (2020): abr./mayo/jun.; e-01764 Revista Brasileira de Cancerologia; v. 66 n. 2 (2020): abr./maio/jun.; e-01764 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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