Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil

Detalhes bibliográficos
Autor(a) principal: Böger,Beatriz
Data de Publicação: 2018
Outros Autores: Amaral,Bianca do, Estevão,Priscila Lagner da Silveira, Wagner,Ricardo, Peralta-Zamora,Patricio Guillermo, Gomes,Eliane Carneiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Ambiente & Água
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000200308
Resumo: Abstract This work sought to determine the two psychotropic drugs most commonly released by Psychosocial Care Centers (CAPS) into urban river waters (Belém sub-basin, Curitiba, PR, Brazil). A simple analytical method using SPE followed by a HPLC-DAD was developed and validated. Strata-X® cartridges were used to extract (carbamazepine) CZ and diazepam (DZ) from water and SPE conditions were optimized by 23 factorial design. The validated method was specific for target compounds; correlation coefficients were above 0.9998, recovery between 85.8 and 98.4% and precision below 6.60% (RSD, n=3). This method was successfully applied to analyze river samples and pollution hotspots were identified. The CZ and DZ concentrations found ranged from 0.670 to 0.856 µg L-1 and from LOQ to 0.763 µg L-1, respectively, and confirmed that drug consumption is directly related to river pollution in the studied region.
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spelling Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazilcarbamazepinediazepamemerging pollutantsAbstract This work sought to determine the two psychotropic drugs most commonly released by Psychosocial Care Centers (CAPS) into urban river waters (Belém sub-basin, Curitiba, PR, Brazil). A simple analytical method using SPE followed by a HPLC-DAD was developed and validated. Strata-X® cartridges were used to extract (carbamazepine) CZ and diazepam (DZ) from water and SPE conditions were optimized by 23 factorial design. The validated method was specific for target compounds; correlation coefficients were above 0.9998, recovery between 85.8 and 98.4% and precision below 6.60% (RSD, n=3). This method was successfully applied to analyze river samples and pollution hotspots were identified. The CZ and DZ concentrations found ranged from 0.670 to 0.856 µg L-1 and from LOQ to 0.763 µg L-1, respectively, and confirmed that drug consumption is directly related to river pollution in the studied region.Instituto de Pesquisas Ambientais em Bacias Hidrográficas2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000200308Revista Ambiente & Água v.13 n.2 2018reponame:Revista Ambiente & Águainstname:Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)instacron:IPABHI10.4136/ambi-agua.2196info:eu-repo/semantics/openAccessBöger,BeatrizAmaral,Bianca doEstevão,Priscila Lagner da SilveiraWagner,RicardoPeralta-Zamora,Patricio GuillermoGomes,Eliane Carneiroeng2018-04-12T00:00:00Zoai:scielo:S1980-993X2018000200308Revistahttp://www.ambi-agua.net/PUBhttps://old.scielo.br/oai/scielo-oai.php||ambi.agua@gmail.com1980-993X1980-993Xopendoar:2018-04-12T00:00Revista Ambiente & Água - Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)false
dc.title.none.fl_str_mv Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
title Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
spellingShingle Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
Böger,Beatriz
carbamazepine
diazepam
emerging pollutants
title_short Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
title_full Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
title_fullStr Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
title_full_unstemmed Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
title_sort Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
author Böger,Beatriz
author_facet Böger,Beatriz
Amaral,Bianca do
Estevão,Priscila Lagner da Silveira
Wagner,Ricardo
Peralta-Zamora,Patricio Guillermo
Gomes,Eliane Carneiro
author_role author
author2 Amaral,Bianca do
Estevão,Priscila Lagner da Silveira
Wagner,Ricardo
Peralta-Zamora,Patricio Guillermo
Gomes,Eliane Carneiro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Böger,Beatriz
Amaral,Bianca do
Estevão,Priscila Lagner da Silveira
Wagner,Ricardo
Peralta-Zamora,Patricio Guillermo
Gomes,Eliane Carneiro
dc.subject.por.fl_str_mv carbamazepine
diazepam
emerging pollutants
topic carbamazepine
diazepam
emerging pollutants
description Abstract This work sought to determine the two psychotropic drugs most commonly released by Psychosocial Care Centers (CAPS) into urban river waters (Belém sub-basin, Curitiba, PR, Brazil). A simple analytical method using SPE followed by a HPLC-DAD was developed and validated. Strata-X® cartridges were used to extract (carbamazepine) CZ and diazepam (DZ) from water and SPE conditions were optimized by 23 factorial design. The validated method was specific for target compounds; correlation coefficients were above 0.9998, recovery between 85.8 and 98.4% and precision below 6.60% (RSD, n=3). This method was successfully applied to analyze river samples and pollution hotspots were identified. The CZ and DZ concentrations found ranged from 0.670 to 0.856 µg L-1 and from LOQ to 0.763 µg L-1, respectively, and confirmed that drug consumption is directly related to river pollution in the studied region.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000200308
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000200308
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.4136/ambi-agua.2196
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Pesquisas Ambientais em Bacias Hidrográficas
publisher.none.fl_str_mv Instituto de Pesquisas Ambientais em Bacias Hidrográficas
dc.source.none.fl_str_mv Revista Ambiente & Água v.13 n.2 2018
reponame:Revista Ambiente & Água
instname:Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)
instacron:IPABHI
instname_str Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)
instacron_str IPABHI
institution IPABHI
reponame_str Revista Ambiente & Água
collection Revista Ambiente & Água
repository.name.fl_str_mv Revista Ambiente & Água - Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)
repository.mail.fl_str_mv ||ambi.agua@gmail.com
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