FTIR analysis of human dentin submitted to gamma radiation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo de conferência |
Título da fonte: | Repositório Institucional do IPEN |
Texto Completo: | http://repositorio.ipen.br/handle/123456789/30585 |
Resumo: | Global data indicate that head and neck cancer express one of the sixth most common types of malignant cancers. In 2030, head and neck cancer predict 1,031,439 new cases per year around the world. Radiation therapy is used as a major therapy step in the treatment protocol for head and neck malignancies. Radiation caries consists in a side effect of xerostomia, ie a considerable reduction in the quantity and quality of saliva in the oral cavity, being defined as a type of cavity that advance severely with fast progression being able to injure the dental pulp. Gamma radiation effects can promote changes associated to modification in the enamel prismatic structure, the reduction in surface microhardness and biochemically alterations in the tooth composition. However, other studies where the human dental enamel using ionizing radiation present no differences found in the integrity of the dental enamel and there was no interference in the surface microhardness. In this study, 20 human dentin samples were evaluated, split randomly into the control group and irradiated group at 25 kGy, in the Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The FTIR shows that no significant changes were found in the Phosphate band representing the inorganic material. On the other hand, the Amide I band -chosen as the representative of the organic matrix composed mainly of collagen- showed a significant difference, suggesting a degradation of the organic content. These findings corroborate with SEM analysis after the gamma irradiation dose at 25 kGy. |
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2020-01-07T13:28:27Z2020-01-07T13:28:27ZOctober 21-25, 2019http://repositorio.ipen.br/handle/123456789/305850000-0001-7404-9606Global data indicate that head and neck cancer express one of the sixth most common types of malignant cancers. In 2030, head and neck cancer predict 1,031,439 new cases per year around the world. Radiation therapy is used as a major therapy step in the treatment protocol for head and neck malignancies. Radiation caries consists in a side effect of xerostomia, ie a considerable reduction in the quantity and quality of saliva in the oral cavity, being defined as a type of cavity that advance severely with fast progression being able to injure the dental pulp. Gamma radiation effects can promote changes associated to modification in the enamel prismatic structure, the reduction in surface microhardness and biochemically alterations in the tooth composition. However, other studies where the human dental enamel using ionizing radiation present no differences found in the integrity of the dental enamel and there was no interference in the surface microhardness. In this study, 20 human dentin samples were evaluated, split randomly into the control group and irradiated group at 25 kGy, in the Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The FTIR shows that no significant changes were found in the Phosphate band representing the inorganic material. On the other hand, the Amide I band -chosen as the representative of the organic matrix composed mainly of collagen- showed a significant difference, suggesting a degradation of the organic content. These findings corroborate with SEM analysis after the gamma irradiation dose at 25 kGy.Submitted by Celia Satomi Uehara (celia.u-topservice@ipen.br) on 2020-01-07T13:28:27Z No. of bitstreams: 1 26235.pdf: 615459 bytes, checksum: 06c1e8868a0aa7ffc8de53eb7e8d7e4a (MD5)Made available in DSpace on 2020-01-07T13:28:27Z (GMT). No. of bitstreams: 1 26235.pdf: 615459 bytes, checksum: 06c1e8868a0aa7ffc8de53eb7e8d7e4a (MD5)Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (CNPq)Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior (CAPES)Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)CNPq-INCT: 465763/2014-6CNPQ-PQ: 309902/2017-7CAPES-PROCAD: 88881.068505/2014-01FAPESP: 05/51689-2; 17/50332-01810-1818Associa????o Brasileira de Energia Nuclearcariesdentinenamelsfourier transformationgamma radiationinfrared spectraradiation dosesside effectstherapyFTIR analysis of human dentin submitted to gamma radiationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINACIRio de JaneiroSantos, SP14973796612053150181503314972693600600600600600600600KUCHAR, NIELSEN G.ZAMATARO, CLAUDIA B.CASTRO, PEDRO A.A. deRABELO, THAIS F.JUVINO, AMANDA C.ZANINI, NATHALIAZEZELL, DENISE M.INTERNATIONAL NUCLEAR ATLANTIC CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN262352019ZEZELL, DENISE M.ZANINI, NATHALIAJUVINO, AMANDA C.RABELO, THAIS F.CASTRO, PEDRO A.A. deZAMATARO, CLAUDIA B.KUCHAR, NIELSEN G.20-01Proceedings69314972150331501812053796614973ZEZELL, DENISE M.:693:920:NZANINI, NATHALIA:14972:-1:NJUVINO, AMANDA C.:15033:-1:NRABELO, THAIS F.:15018:-1:NCASTRO, PEDRO A.A. de:12053:920:NZAMATARO, CLAUDIA B.:7966:920:NKUCHAR, NIELSEN G.:14973:-1:SORIGINAL26235.pdf26235.pdfapplication/pdf615459http://repositorio.ipen.br/bitstream/123456789/30585/1/26235.pdf06c1e8868a0aa7ffc8de53eb7e8d7e4aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/30585/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/305852020-04-06 14:03:10.839oai:repositorio.ipen.br:123456789/30585Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102020-04-06T14:03:10Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false |
dc.title.pt_BR.fl_str_mv |
FTIR analysis of human dentin submitted to gamma radiation |
title |
FTIR analysis of human dentin submitted to gamma radiation |
spellingShingle |
FTIR analysis of human dentin submitted to gamma radiation KUCHAR, NIELSEN G. caries dentin enamels fourier transformation gamma radiation infrared spectra radiation doses side effects therapy |
title_short |
FTIR analysis of human dentin submitted to gamma radiation |
title_full |
FTIR analysis of human dentin submitted to gamma radiation |
title_fullStr |
FTIR analysis of human dentin submitted to gamma radiation |
title_full_unstemmed |
FTIR analysis of human dentin submitted to gamma radiation |
title_sort |
FTIR analysis of human dentin submitted to gamma radiation |
author |
KUCHAR, NIELSEN G. |
author_facet |
KUCHAR, NIELSEN G. ZAMATARO, CLAUDIA B. CASTRO, PEDRO A.A. de RABELO, THAIS F. JUVINO, AMANDA C. ZANINI, NATHALIA ZEZELL, DENISE M. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
author_role |
author |
author2 |
ZAMATARO, CLAUDIA B. CASTRO, PEDRO A.A. de RABELO, THAIS F. JUVINO, AMANDA C. ZANINI, NATHALIA ZEZELL, DENISE M. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
KUCHAR, NIELSEN G. ZAMATARO, CLAUDIA B. CASTRO, PEDRO A.A. de RABELO, THAIS F. JUVINO, AMANDA C. ZANINI, NATHALIA ZEZELL, DENISE M. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
dc.subject.por.fl_str_mv |
caries dentin enamels fourier transformation gamma radiation infrared spectra radiation doses side effects therapy |
topic |
caries dentin enamels fourier transformation gamma radiation infrared spectra radiation doses side effects therapy |
description |
Global data indicate that head and neck cancer express one of the sixth most common types of malignant cancers. In 2030, head and neck cancer predict 1,031,439 new cases per year around the world. Radiation therapy is used as a major therapy step in the treatment protocol for head and neck malignancies. Radiation caries consists in a side effect of xerostomia, ie a considerable reduction in the quantity and quality of saliva in the oral cavity, being defined as a type of cavity that advance severely with fast progression being able to injure the dental pulp. Gamma radiation effects can promote changes associated to modification in the enamel prismatic structure, the reduction in surface microhardness and biochemically alterations in the tooth composition. However, other studies where the human dental enamel using ionizing radiation present no differences found in the integrity of the dental enamel and there was no interference in the surface microhardness. In this study, 20 human dentin samples were evaluated, split randomly into the control group and irradiated group at 25 kGy, in the Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The FTIR shows that no significant changes were found in the Phosphate band representing the inorganic material. On the other hand, the Amide I band -chosen as the representative of the organic matrix composed mainly of collagen- showed a significant difference, suggesting a degradation of the organic content. These findings corroborate with SEM analysis after the gamma irradiation dose at 25 kGy. |
publishDate |
2020 |
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October 21-25, 2019 |
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2020-01-07T13:28:27Z |
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2020-01-07T13:28:27Z |
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