Chlorhexidine loaded MMT as dental composite filler: release evaluation
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo de conferência |
Título da fonte: | Repositório Institucional do IPEN |
Texto Completo: | http://repositorio.ipen.br/handle/123456789/26738 |
Resumo: | Polymeric restorative materials are widely used, however polymerization shrinkage still stands as a major drawback as it allows microleakage, secondary caries, postoperative sensitivity and cusp deflection. A polymeric material with antimicrobial activity could be very useful in many dental procedures including adhesive cementation, sealants, dental adhesives and direct restorative material. The aim of this study was to develop nanocomposites for dental purposes composed by chlorhexidine loaded montmorillonite (Cloisite 30B) nanoparticles in a BisGMA / TEGDMA organic matrix. The specimens of experimental composites were synthesized with 10 % (w/w) of diacetate chlorhexidine incorporated in a MMT, as filler. The chlorhexidine release at 37 oC was evaluated in vitro in physiological solution at neutral pH for 366 hours. Drug content was estimated by UV spectroscopy at ??=255 nm. Significant drug release initiated after 96 hours and maintained throughout the experiment. In conclusion, the composite was capable of promoting chlorhexidine release over time, and such results in addition to the lack of significant weight loss (??? 1.43 %) and the very low swelling (??? 2.22 %) properties, revealed the strong potential of the developed composite for further dental and other biomaterial applications. |
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2016-10-10T13:12:56Z2016-10-10T13:12:56ZAugust 28-31, 2016http://repositorio.ipen.br/handle/123456789/26738Polymeric restorative materials are widely used, however polymerization shrinkage still stands as a major drawback as it allows microleakage, secondary caries, postoperative sensitivity and cusp deflection. A polymeric material with antimicrobial activity could be very useful in many dental procedures including adhesive cementation, sealants, dental adhesives and direct restorative material. The aim of this study was to develop nanocomposites for dental purposes composed by chlorhexidine loaded montmorillonite (Cloisite 30B) nanoparticles in a BisGMA / TEGDMA organic matrix. The specimens of experimental composites were synthesized with 10 % (w/w) of diacetate chlorhexidine incorporated in a MMT, as filler. The chlorhexidine release at 37 oC was evaluated in vitro in physiological solution at neutral pH for 366 hours. Drug content was estimated by UV spectroscopy at ??=255 nm. Significant drug release initiated after 96 hours and maintained throughout the experiment. In conclusion, the composite was capable of promoting chlorhexidine release over time, and such results in addition to the lack of significant weight loss (??? 1.43 %) and the very low swelling (??? 2.22 %) properties, revealed the strong potential of the developed composite for further dental and other biomaterial applications.Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2016-10-10T13:12:56Z No. of bitstreams: 1 22624.pdf: 352267 bytes, checksum: b09656c1f0370b7ed439b9ed4c94ee98 (MD5)Made available in DSpace on 2016-10-10T13:12:56Z (GMT). No. of bitstreams: 1 22624.pdf: 352267 bytes, checksum: b09656c1f0370b7ed439b9ed4c94ee98 (MD5)Chlorhexidine loaded MMT as dental composite filler: release evaluationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectBCCMIGramado, RSCAMPOS, LUIZA M.BOARO, LETICIA C.SANTOS, TAMIRIS R.SANTOS, VINICIUS J.VARCA, GUSTAVO C.PARRA, DUCLERC F.BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rdinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN226242016CAMPOS, LUIZA M.SANTOS, TAMIRIS R.SANTOS, VINICIUS J.VARCA, GUSTAVO C.PARRA, DUCLERC F.16-10Proceedings72191399514044562CAMPOS, LUIZA M.:7219:-1:SBOARO, LETICIA C.:13995:-1:NSANTOS, VINICIUS J.:14044:-1:NPARRA, DUCLERC F.:562:740:NORIGINAL22624.pdf22624.pdfapplication/pdf352267http://repositorio.ipen.br/bitstream/123456789/26738/1/22624.pdfb09656c1f0370b7ed439b9ed4c94ee98MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/26738/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/267382016-10-10 13:12:56.148oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102016-10-10T13:12:56Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false |
dc.title.pt_BR.fl_str_mv |
Chlorhexidine loaded MMT as dental composite filler: release evaluation |
title |
Chlorhexidine loaded MMT as dental composite filler: release evaluation |
spellingShingle |
Chlorhexidine loaded MMT as dental composite filler: release evaluation CAMPOS, LUIZA M. |
title_short |
Chlorhexidine loaded MMT as dental composite filler: release evaluation |
title_full |
Chlorhexidine loaded MMT as dental composite filler: release evaluation |
title_fullStr |
Chlorhexidine loaded MMT as dental composite filler: release evaluation |
title_full_unstemmed |
Chlorhexidine loaded MMT as dental composite filler: release evaluation |
title_sort |
Chlorhexidine loaded MMT as dental composite filler: release evaluation |
author |
CAMPOS, LUIZA M. |
author_facet |
CAMPOS, LUIZA M. BOARO, LETICIA C. SANTOS, TAMIRIS R. SANTOS, VINICIUS J. VARCA, GUSTAVO C. PARRA, DUCLERC F. BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd |
author_role |
author |
author2 |
BOARO, LETICIA C. SANTOS, TAMIRIS R. SANTOS, VINICIUS J. VARCA, GUSTAVO C. PARRA, DUCLERC F. BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
CAMPOS, LUIZA M. BOARO, LETICIA C. SANTOS, TAMIRIS R. SANTOS, VINICIUS J. VARCA, GUSTAVO C. PARRA, DUCLERC F. BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd |
description |
Polymeric restorative materials are widely used, however polymerization shrinkage still stands as a major drawback as it allows microleakage, secondary caries, postoperative sensitivity and cusp deflection. A polymeric material with antimicrobial activity could be very useful in many dental procedures including adhesive cementation, sealants, dental adhesives and direct restorative material. The aim of this study was to develop nanocomposites for dental purposes composed by chlorhexidine loaded montmorillonite (Cloisite 30B) nanoparticles in a BisGMA / TEGDMA organic matrix. The specimens of experimental composites were synthesized with 10 % (w/w) of diacetate chlorhexidine incorporated in a MMT, as filler. The chlorhexidine release at 37 oC was evaluated in vitro in physiological solution at neutral pH for 366 hours. Drug content was estimated by UV spectroscopy at ??=255 nm. Significant drug release initiated after 96 hours and maintained throughout the experiment. In conclusion, the composite was capable of promoting chlorhexidine release over time, and such results in addition to the lack of significant weight loss (??? 1.43 %) and the very low swelling (??? 2.22 %) properties, revealed the strong potential of the developed composite for further dental and other biomaterial applications. |
publishDate |
2016 |
dc.date.evento.pt_BR.fl_str_mv |
August 28-31, 2016 |
dc.date.accessioned.fl_str_mv |
2016-10-10T13:12:56Z |
dc.date.available.fl_str_mv |
2016-10-10T13:12:56Z |
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info:eu-repo/semantics/publishedVersion |
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conferenceObject |
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http://repositorio.ipen.br/handle/123456789/26738 |
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http://repositorio.ipen.br/handle/123456789/26738 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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I |
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