Chlorhexidine loaded MMT as dental composite filler: release evaluation

Detalhes bibliográficos
Autor(a) principal: CAMPOS, LUIZA M.
Data de Publicação: 2016
Outros Autores: BOARO, LETICIA C., SANTOS, TAMIRIS R., SANTOS, VINICIUS J., VARCA, GUSTAVO C., PARRA, DUCLERC F., BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd
Tipo de documento: Artigo de conferência
Título da fonte: Repositório Institucional do IPEN
Texto Completo: http://repositorio.ipen.br/handle/123456789/26738
Resumo: Polymeric restorative materials are widely used, however polymerization shrinkage still stands as a major drawback as it allows microleakage, secondary caries, postoperative sensitivity and cusp deflection. A polymeric material with antimicrobial activity could be very useful in many dental procedures including adhesive cementation, sealants, dental adhesives and direct restorative material. The aim of this study was to develop nanocomposites for dental purposes composed by chlorhexidine loaded montmorillonite (Cloisite 30B) nanoparticles in a BisGMA / TEGDMA organic matrix. The specimens of experimental composites were synthesized with 10 % (w/w) of diacetate chlorhexidine incorporated in a MMT, as filler. The chlorhexidine release at 37 oC was evaluated in vitro in physiological solution at neutral pH for 366 hours. Drug content was estimated by UV spectroscopy at ??=255 nm. Significant drug release initiated after 96 hours and maintained throughout the experiment. In conclusion, the composite was capable of promoting chlorhexidine release over time, and such results in addition to the lack of significant weight loss (??? 1.43 %) and the very low swelling (??? 2.22 %) properties, revealed the strong potential of the developed composite for further dental and other biomaterial applications.
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spelling 2016-10-10T13:12:56Z2016-10-10T13:12:56ZAugust 28-31, 2016http://repositorio.ipen.br/handle/123456789/26738Polymeric restorative materials are widely used, however polymerization shrinkage still stands as a major drawback as it allows microleakage, secondary caries, postoperative sensitivity and cusp deflection. A polymeric material with antimicrobial activity could be very useful in many dental procedures including adhesive cementation, sealants, dental adhesives and direct restorative material. The aim of this study was to develop nanocomposites for dental purposes composed by chlorhexidine loaded montmorillonite (Cloisite 30B) nanoparticles in a BisGMA / TEGDMA organic matrix. The specimens of experimental composites were synthesized with 10 % (w/w) of diacetate chlorhexidine incorporated in a MMT, as filler. The chlorhexidine release at 37 oC was evaluated in vitro in physiological solution at neutral pH for 366 hours. Drug content was estimated by UV spectroscopy at ??=255 nm. Significant drug release initiated after 96 hours and maintained throughout the experiment. In conclusion, the composite was capable of promoting chlorhexidine release over time, and such results in addition to the lack of significant weight loss (??? 1.43 %) and the very low swelling (??? 2.22 %) properties, revealed the strong potential of the developed composite for further dental and other biomaterial applications.Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2016-10-10T13:12:56Z No. of bitstreams: 1 22624.pdf: 352267 bytes, checksum: b09656c1f0370b7ed439b9ed4c94ee98 (MD5)Made available in DSpace on 2016-10-10T13:12:56Z (GMT). No. of bitstreams: 1 22624.pdf: 352267 bytes, checksum: b09656c1f0370b7ed439b9ed4c94ee98 (MD5)Chlorhexidine loaded MMT as dental composite filler: release evaluationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectBCCMIGramado, RSCAMPOS, LUIZA M.BOARO, LETICIA C.SANTOS, TAMIRIS R.SANTOS, VINICIUS J.VARCA, GUSTAVO C.PARRA, DUCLERC F.BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rdinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN226242016CAMPOS, LUIZA M.SANTOS, TAMIRIS R.SANTOS, VINICIUS J.VARCA, GUSTAVO C.PARRA, DUCLERC F.16-10Proceedings72191399514044562CAMPOS, LUIZA M.:7219:-1:SBOARO, LETICIA C.:13995:-1:NSANTOS, VINICIUS J.:14044:-1:NPARRA, DUCLERC F.:562:740:NORIGINAL22624.pdf22624.pdfapplication/pdf352267http://repositorio.ipen.br/bitstream/123456789/26738/1/22624.pdfb09656c1f0370b7ed439b9ed4c94ee98MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/26738/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/267382016-10-10 13:12:56.148oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102016-10-10T13:12:56Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false
dc.title.pt_BR.fl_str_mv Chlorhexidine loaded MMT as dental composite filler: release evaluation
title Chlorhexidine loaded MMT as dental composite filler: release evaluation
spellingShingle Chlorhexidine loaded MMT as dental composite filler: release evaluation
CAMPOS, LUIZA M.
title_short Chlorhexidine loaded MMT as dental composite filler: release evaluation
title_full Chlorhexidine loaded MMT as dental composite filler: release evaluation
title_fullStr Chlorhexidine loaded MMT as dental composite filler: release evaluation
title_full_unstemmed Chlorhexidine loaded MMT as dental composite filler: release evaluation
title_sort Chlorhexidine loaded MMT as dental composite filler: release evaluation
author CAMPOS, LUIZA M.
author_facet CAMPOS, LUIZA M.
BOARO, LETICIA C.
SANTOS, TAMIRIS R.
SANTOS, VINICIUS J.
VARCA, GUSTAVO C.
PARRA, DUCLERC F.
BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd
author_role author
author2 BOARO, LETICIA C.
SANTOS, TAMIRIS R.
SANTOS, VINICIUS J.
VARCA, GUSTAVO C.
PARRA, DUCLERC F.
BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv CAMPOS, LUIZA M.
BOARO, LETICIA C.
SANTOS, TAMIRIS R.
SANTOS, VINICIUS J.
VARCA, GUSTAVO C.
PARRA, DUCLERC F.
BRAZILIAN CONFERENCE ON COMPOSITE MATERIALS, 3rd
description Polymeric restorative materials are widely used, however polymerization shrinkage still stands as a major drawback as it allows microleakage, secondary caries, postoperative sensitivity and cusp deflection. A polymeric material with antimicrobial activity could be very useful in many dental procedures including adhesive cementation, sealants, dental adhesives and direct restorative material. The aim of this study was to develop nanocomposites for dental purposes composed by chlorhexidine loaded montmorillonite (Cloisite 30B) nanoparticles in a BisGMA / TEGDMA organic matrix. The specimens of experimental composites were synthesized with 10 % (w/w) of diacetate chlorhexidine incorporated in a MMT, as filler. The chlorhexidine release at 37 oC was evaluated in vitro in physiological solution at neutral pH for 366 hours. Drug content was estimated by UV spectroscopy at ??=255 nm. Significant drug release initiated after 96 hours and maintained throughout the experiment. In conclusion, the composite was capable of promoting chlorhexidine release over time, and such results in addition to the lack of significant weight loss (??? 1.43 %) and the very low swelling (??? 2.22 %) properties, revealed the strong potential of the developed composite for further dental and other biomaterial applications.
publishDate 2016
dc.date.evento.pt_BR.fl_str_mv August 28-31, 2016
dc.date.accessioned.fl_str_mv 2016-10-10T13:12:56Z
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