On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route

Detalhes bibliográficos
Autor(a) principal: GENEZINI, FREDERICO A.
Data de Publicação: 2020
Outros Autores: ZAHN, GUILHERME S., SILVA, PAULO S.C. da, NORY, RENATA M., MOREIRA, EDSON G., SANTIAGO, PAULO S., INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
Tipo de documento: Artigo de conferência
Título da fonte: Repositório Institucional do IPEN
Texto Completo: http://repositorio.ipen.br/handle/123456789/30580
Resumo: Over the last years the 177Lu radioisotope has attracted great interest for the use in therapeutic and diagnostic procedures simultaneously, being what is now called a theranostic radioisotope. There are mainly two ways of producing this radioisotope, by direct neutron capture in a 176Lu target (the \direct route") or by irradiating a 176Yb sample, producing 177Yb that will then decay to 177Lu (also referred as the \indirect route"). In this work the feasibility of producing 177Lu in the IEA-R1 nuclear reactor via the direct route was assessed, and the speci c activity that could be obtained was estimated both experimentally and theoretically, allowing for a discussion on the feasibility of commercially producing 177Lu by 176Lu neutron capture in the IEA-R1 reactor.
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spelling 2020-01-07T11:18:22Z2020-01-07T11:18:22ZOctober 21-25, 2019http://repositorio.ipen.br/handle/123456789/305800000-0002-6318-6805Over the last years the 177Lu radioisotope has attracted great interest for the use in therapeutic and diagnostic procedures simultaneously, being what is now called a theranostic radioisotope. There are mainly two ways of producing this radioisotope, by direct neutron capture in a 176Lu target (the \direct route") or by irradiating a 176Yb sample, producing 177Yb that will then decay to 177Lu (also referred as the \indirect route"). In this work the feasibility of producing 177Lu in the IEA-R1 nuclear reactor via the direct route was assessed, and the speci c activity that could be obtained was estimated both experimentally and theoretically, allowing for a discussion on the feasibility of commercially producing 177Lu by 176Lu neutron capture in the IEA-R1 reactor.Submitted by Celia Satomi Uehara (celia.u-topservice@ipen.br) on 2020-01-07T11:18:22Z No. of bitstreams: 1 26230.pdf: 339630 bytes, checksum: 1d26afb815369916a4308f512043e19d (MD5)Made available in DSpace on 2020-01-07T11:18:22Z (GMT). No. of bitstreams: 1 26230.pdf: 339630 bytes, checksum: 1d26afb815369916a4308f512043e19d (MD5)1759-1765Associa????o Brasileira de Energia Nuclearcapturefeasibility studiesiear-1 reactorisotope productionlutetium 176 targetlutetium 177neutron reactionsnuclear medicinetherapyOn the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct routeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINACIRio de JaneiroSantos, SP204510050277714363860865600600600600600600GENEZINI, FREDERICO A.ZAHN, GUILHERME S.SILVA, PAULO S.C. daNORY, RENATA M.MOREIRA, EDSON G.SANTIAGO, PAULO S.INTERNATIONAL NUCLEAR ATLANTIC CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN262302019SANTIAGO, PAULO S.MOREIRA, EDSON G.NORY, RENATA M.SILVA, PAULO S.C. daZAHN, GUILHERME S.GENEZINI, FREDERICO A.20-01Proceedings865860143632777100502045SANTIAGO, PAULO S.:865:-1:NMOREIRA, EDSON G.:860:320:NNORY, RENATA M.:14363:320:NSILVA, PAULO S.C. da:2777:320:NZAHN, GUILHERME S.:10050:-1:NGENEZINI, FREDERICO A.:2045:310:SORIGINAL26230.pdf26230.pdfapplication/pdf339630http://repositorio.ipen.br/bitstream/123456789/30580/1/26230.pdf1d26afb815369916a4308f512043e19dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/30580/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/305802020-03-23 18:58:34.792oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102020-03-23T18:58:34Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false
dc.title.pt_BR.fl_str_mv On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route
title On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route
spellingShingle On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route
GENEZINI, FREDERICO A.
capture
feasibility studies
iear-1 reactor
isotope production
lutetium 176 target
lutetium 177
neutron reactions
nuclear medicine
therapy
title_short On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route
title_full On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route
title_fullStr On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route
title_full_unstemmed On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route
title_sort On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route
author GENEZINI, FREDERICO A.
author_facet GENEZINI, FREDERICO A.
ZAHN, GUILHERME S.
SILVA, PAULO S.C. da
NORY, RENATA M.
MOREIRA, EDSON G.
SANTIAGO, PAULO S.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
author_role author
author2 ZAHN, GUILHERME S.
SILVA, PAULO S.C. da
NORY, RENATA M.
MOREIRA, EDSON G.
SANTIAGO, PAULO S.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv GENEZINI, FREDERICO A.
ZAHN, GUILHERME S.
SILVA, PAULO S.C. da
NORY, RENATA M.
MOREIRA, EDSON G.
SANTIAGO, PAULO S.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
dc.subject.por.fl_str_mv capture
feasibility studies
iear-1 reactor
isotope production
lutetium 176 target
lutetium 177
neutron reactions
nuclear medicine
therapy
topic capture
feasibility studies
iear-1 reactor
isotope production
lutetium 176 target
lutetium 177
neutron reactions
nuclear medicine
therapy
description Over the last years the 177Lu radioisotope has attracted great interest for the use in therapeutic and diagnostic procedures simultaneously, being what is now called a theranostic radioisotope. There are mainly two ways of producing this radioisotope, by direct neutron capture in a 176Lu target (the \direct route") or by irradiating a 176Yb sample, producing 177Yb that will then decay to 177Lu (also referred as the \indirect route"). In this work the feasibility of producing 177Lu in the IEA-R1 nuclear reactor via the direct route was assessed, and the speci c activity that could be obtained was estimated both experimentally and theoretically, allowing for a discussion on the feasibility of commercially producing 177Lu by 176Lu neutron capture in the IEA-R1 reactor.
publishDate 2020
dc.date.evento.pt_BR.fl_str_mv October 21-25, 2019
dc.date.accessioned.fl_str_mv 2020-01-07T11:18:22Z
dc.date.available.fl_str_mv 2020-01-07T11:18:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
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dc.identifier.uri.fl_str_mv http://repositorio.ipen.br/handle/123456789/30580
dc.identifier.orcid.pt_BR.fl_str_mv 0000-0002-6318-6805
url http://repositorio.ipen.br/handle/123456789/30580
identifier_str_mv 0000-0002-6318-6805
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv 1759-1765
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dc.publisher.none.fl_str_mv Associa????o Brasileira de Energia Nuclear
publisher.none.fl_str_mv Associa????o Brasileira de Energia Nuclear
dc.source.none.fl_str_mv reponame:Repositório Institucional do IPEN
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