A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Título da fonte: | Repositório Institucional do IPEN |
Texto Completo: | http://repositorio.ipen.br/handle/123456789/28294 |
Resumo: | Since 2001 the Nuclear and Energy Research Institute (IPEN/CNEN-SP, Brazil) has produced about 2.5 mCi/mAh of 123I weekly using a manual irradiation system fully developed by its researchers. Ultrapure 123I has been produced and distributed to hospitals and clinics where several diagnostic imaging procedures are done for thyroid, brain and cardiovascular functions. Due to the short half-life and emission of low-energy photons, this radioisotope becomes suitable for diagnosis in children. Currently IPEN researchers are involved in the development of a new fully automated irradiation system dedicated to 123I routine production employing enriched xenon gas (124Xe) as the target material. This new system consists of a target port, a water and a helium cooling system, a cryogenic system, an electric power system, a control and process monitoring unit composed of a supervisory software connected to a Programmable Logic Controller (PLC) via personal computer. In this new concept, there is no need for human interference during radioisotope production, reducing the possibility of eventual failures or incidents involving radioactive material. In this way, with this new system, a specific yield of approximately 3.5 mCi/mAh per irradiation is expected and this will meet a large part of the national demand for this important radioisotope. In the present work will be presented all the technical and constructive aspects of this new system as well as the results obtained in the irradiation of tests. |
id |
IPEN_908d41fb990cc67d73fcee9ff2081f91 |
---|---|
oai_identifier_str |
oai:repositorio.ipen.br:123456789/28294 |
network_acronym_str |
IPEN |
network_name_str |
Repositório Institucional do IPEN |
repository_id_str |
4510 |
spelling |
2018-01-11T16:50:51Z2018-01-11T16:50:51ZOctober 22-27, 2017http://repositorio.ipen.br/handle/123456789/28294Since 2001 the Nuclear and Energy Research Institute (IPEN/CNEN-SP, Brazil) has produced about 2.5 mCi/mAh of 123I weekly using a manual irradiation system fully developed by its researchers. Ultrapure 123I has been produced and distributed to hospitals and clinics where several diagnostic imaging procedures are done for thyroid, brain and cardiovascular functions. Due to the short half-life and emission of low-energy photons, this radioisotope becomes suitable for diagnosis in children. Currently IPEN researchers are involved in the development of a new fully automated irradiation system dedicated to 123I routine production employing enriched xenon gas (124Xe) as the target material. This new system consists of a target port, a water and a helium cooling system, a cryogenic system, an electric power system, a control and process monitoring unit composed of a supervisory software connected to a Programmable Logic Controller (PLC) via personal computer. In this new concept, there is no need for human interference during radioisotope production, reducing the possibility of eventual failures or incidents involving radioactive material. In this way, with this new system, a specific yield of approximately 3.5 mCi/mAh per irradiation is expected and this will meet a large part of the national demand for this important radioisotope. In the present work will be presented all the technical and constructive aspects of this new system as well as the results obtained in the irradiation of tests.Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2018-01-11T16:50:51Z No. of bitstreams: 1 24129.pdf: 1066849 bytes, checksum: 587e9702d5fef21af680e0dc5d6dcb3d (MD5)Made available in DSpace on 2018-01-11T16:50:51Z (GMT). No. of bitstreams: 1 24129.pdf: 1066849 bytes, checksum: 587e9702d5fef21af680e0dc5d6dcb3d (MD5)Associa????o Brasileira de Energia Nuclearautomationcyclotronsiodine 123irradiation devicesisotope productionperformance testingremote controlxenon 124A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotroninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINACIRio de Janeiro, RJBelo Horizonte, MGLAPOLLI, ANDRE L.BARCELLOS, HENRIQUEMATSUDA, HYLTONSUMIYA, LUIZ C. do A.JUNQUEIRA, FERNANDO de C.INTERNATIONAL NUCLEAR ATLANTIC CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN241292017LAPOLLI, ANDRE L.MATSUDA, HYLTONSUMIYA, LUIZ C. do A.JUNQUEIRA, FERNANDO de C.BARCELLOS, HENRIQUE18-01Proceedings1541141701283430LAPOLLI, ANDRE L.:154:110:SBARCELLOS, HENRIQUE:1141:110:NMATSUDA, HYLTON:701:110:NSUMIYA, LUIZ C. DO A.:283:110:NJUNQUEIRA, FERNANDO DE C.:430:420:NORIGINAL24129.pdf24129.pdfapplication/pdf1066849http://repositorio.ipen.br/bitstream/123456789/28294/1/24129.pdf587e9702d5fef21af680e0dc5d6dcb3dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/28294/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/282942022-03-23 18:09:08.715oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102022-03-23T18:09:08Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false |
dc.title.pt_BR.fl_str_mv |
A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron |
title |
A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron |
spellingShingle |
A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron LAPOLLI, ANDRE L. automation cyclotrons iodine 123 irradiation devices isotope production performance testing remote control xenon 124 |
title_short |
A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron |
title_full |
A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron |
title_fullStr |
A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron |
title_full_unstemmed |
A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron |
title_sort |
A new 124Xe irradiation system for 123I routine production at the 30 MeV IPEN-CNEN/SP cyclotron |
author |
LAPOLLI, ANDRE L. |
author_facet |
LAPOLLI, ANDRE L. BARCELLOS, HENRIQUE MATSUDA, HYLTON SUMIYA, LUIZ C. do A. JUNQUEIRA, FERNANDO de C. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
author_role |
author |
author2 |
BARCELLOS, HENRIQUE MATSUDA, HYLTON SUMIYA, LUIZ C. do A. JUNQUEIRA, FERNANDO de C. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
LAPOLLI, ANDRE L. BARCELLOS, HENRIQUE MATSUDA, HYLTON SUMIYA, LUIZ C. do A. JUNQUEIRA, FERNANDO de C. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
dc.subject.por.fl_str_mv |
automation cyclotrons iodine 123 irradiation devices isotope production performance testing remote control xenon 124 |
topic |
automation cyclotrons iodine 123 irradiation devices isotope production performance testing remote control xenon 124 |
description |
Since 2001 the Nuclear and Energy Research Institute (IPEN/CNEN-SP, Brazil) has produced about 2.5 mCi/mAh of 123I weekly using a manual irradiation system fully developed by its researchers. Ultrapure 123I has been produced and distributed to hospitals and clinics where several diagnostic imaging procedures are done for thyroid, brain and cardiovascular functions. Due to the short half-life and emission of low-energy photons, this radioisotope becomes suitable for diagnosis in children. Currently IPEN researchers are involved in the development of a new fully automated irradiation system dedicated to 123I routine production employing enriched xenon gas (124Xe) as the target material. This new system consists of a target port, a water and a helium cooling system, a cryogenic system, an electric power system, a control and process monitoring unit composed of a supervisory software connected to a Programmable Logic Controller (PLC) via personal computer. In this new concept, there is no need for human interference during radioisotope production, reducing the possibility of eventual failures or incidents involving radioactive material. In this way, with this new system, a specific yield of approximately 3.5 mCi/mAh per irradiation is expected and this will meet a large part of the national demand for this important radioisotope. In the present work will be presented all the technical and constructive aspects of this new system as well as the results obtained in the irradiation of tests. |
publishDate |
2018 |
dc.date.evento.pt_BR.fl_str_mv |
October 22-27, 2017 |
dc.date.accessioned.fl_str_mv |
2018-01-11T16:50:51Z |
dc.date.available.fl_str_mv |
2018-01-11T16:50:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ipen.br/handle/123456789/28294 |
url |
http://repositorio.ipen.br/handle/123456789/28294 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.coverage.pt_BR.fl_str_mv |
I |
dc.publisher.none.fl_str_mv |
Associa????o Brasileira de Energia Nuclear |
publisher.none.fl_str_mv |
Associa????o Brasileira de Energia Nuclear |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional do IPEN instname:Instituto de Pesquisas Energéticas e Nucleares (IPEN) instacron:IPEN |
instname_str |
Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
instacron_str |
IPEN |
institution |
IPEN |
reponame_str |
Repositório Institucional do IPEN |
collection |
Repositório Institucional do IPEN |
bitstream.url.fl_str_mv |
http://repositorio.ipen.br/bitstream/123456789/28294/1/24129.pdf http://repositorio.ipen.br/bitstream/123456789/28294/2/license.txt |
bitstream.checksum.fl_str_mv |
587e9702d5fef21af680e0dc5d6dcb3d 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
repository.mail.fl_str_mv |
bibl@ipen.br |
_version_ |
1767254243716104192 |