Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo de conferência |
Título da fonte: | Repositório Institucional do IPEN |
Texto Completo: | http://repositorio.ipen.br/handle/123456789/26841 |
Resumo: | The use of Animal House Facilities of IPEN-CNEN/SP has provided rats and mice with controlled sanitary quality for research and quality control in the production of radiopharmaceuticals lots, produced at IPEN, following rules of CONCEA ??? Brazilian National Council for Animal Experimentation Control and approved in Ethics Committee on the Use of Animals (CEUA), before they be sent to hospitals and clinics spread out in Brazil, for use in Nuclear Medicine. The production and the supply of high quality laboratory animals have fundamental importance for the accomplishment of vanguard scientific research, with reproducibility and universality. The quality of those animals depends, largely, of the available facilities for their production and lodging, to assure the demanded sanitary control and animal???s welfare, in agreement with the ethical principles that control the activity. Therefore, the facilities design is of vital importance so that the mentioned requirements can be reached. Nevertheless, pigs and miniature pigs have gained importance as large animal models in medicine. With their size, organ capacity, and physiology resembling in several aspects that of humans, pigs are well suited for preclinical experiments and long-term safety studies. The minipigs will be used for preclinical testing of radiopharmaceuticals and assays radioactive materials for cardiac tests. This paper describes the premises and preliminary activities that have been performed at IPEN for the design of new Animal House Facilities dedicated to keeping minipigs taking into account fundamental aspects such as: animal???s welfare, sanitation, genetic, in agreement with the ethical principles that control the activity and environmental concerns. |
id |
IPEN_ef386434ec4ed7b7b8943c230f13b5e0 |
---|---|
oai_identifier_str |
oai:repositorio.ipen.br:123456789/26841 |
network_acronym_str |
IPEN |
network_name_str |
Repositório Institucional do IPEN |
repository_id_str |
4510 |
spelling |
2016-11-14T13:09:34Z2016-11-14T13:09:34ZOctober 4-9, 2015http://repositorio.ipen.br/handle/123456789/26841The use of Animal House Facilities of IPEN-CNEN/SP has provided rats and mice with controlled sanitary quality for research and quality control in the production of radiopharmaceuticals lots, produced at IPEN, following rules of CONCEA ??? Brazilian National Council for Animal Experimentation Control and approved in Ethics Committee on the Use of Animals (CEUA), before they be sent to hospitals and clinics spread out in Brazil, for use in Nuclear Medicine. The production and the supply of high quality laboratory animals have fundamental importance for the accomplishment of vanguard scientific research, with reproducibility and universality. The quality of those animals depends, largely, of the available facilities for their production and lodging, to assure the demanded sanitary control and animal???s welfare, in agreement with the ethical principles that control the activity. Therefore, the facilities design is of vital importance so that the mentioned requirements can be reached. Nevertheless, pigs and miniature pigs have gained importance as large animal models in medicine. With their size, organ capacity, and physiology resembling in several aspects that of humans, pigs are well suited for preclinical experiments and long-term safety studies. The minipigs will be used for preclinical testing of radiopharmaceuticals and assays radioactive materials for cardiac tests. This paper describes the premises and preliminary activities that have been performed at IPEN for the design of new Animal House Facilities dedicated to keeping minipigs taking into account fundamental aspects such as: animal???s welfare, sanitation, genetic, in agreement with the ethical principles that control the activity and environmental concerns.Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-11-14T13:09:34Z No. of bitstreams: 1 22638.pdf: 475815 bytes, checksum: 6c400f353a7b8d925551f877c38f8074 (MD5)Made available in DSpace on 2016-11-14T13:09:34Z (GMT). No. of bitstreams: 1 22638.pdf: 475815 bytes, checksum: 6c400f353a7b8d925551f877c38f8074 (MD5)proposalsanimalsmammalsequipmentradiopharmaceuticalsdrugsConceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINAC; ENAN; ENFIR; ENINIS??o Paulo, SPLAINETTI, ELIZABETH B.F.SOARES, CARLOS R.J.NASCIMENTO, NANCI doINTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 12th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 19th; MEETING ON NUCLEAR INDUSTRY, 4thinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN226382015LAINETTI, ELIZABETH B.F.SOARES, CARLOS R.J.NASCIMENTO, NANCI do16-11Proceedings1417509411LAINETTI, ELIZABETH B.F.:1417:1360:SSOARES, CARLOS R.J.:509:810:NNASCIMENTO, NANCI DO:411:820:NORIGINAL22638.pdf22638.pdfapplication/pdf475815http://repositorio.ipen.br/bitstream/123456789/26841/1/22638.pdf6c400f353a7b8d925551f877c38f8074MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/26841/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/268412016-11-23 16:37:54.282oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102016-11-23T16:37:54Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false |
dc.title.pt_BR.fl_str_mv |
Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research |
title |
Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research |
spellingShingle |
Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research LAINETTI, ELIZABETH B.F. proposals animals mammals equipment radiopharmaceuticals drugs |
title_short |
Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research |
title_full |
Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research |
title_fullStr |
Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research |
title_full_unstemmed |
Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research |
title_sort |
Conceptual proposal of a facility for handlings of minipigs for pharmaceutical and radiopharmaceutical research |
author |
LAINETTI, ELIZABETH B.F. |
author_facet |
LAINETTI, ELIZABETH B.F. SOARES, CARLOS R.J. NASCIMENTO, NANCI do INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 12th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 19th; MEETING ON NUCLEAR INDUSTRY, 4th |
author_role |
author |
author2 |
SOARES, CARLOS R.J. NASCIMENTO, NANCI do INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 12th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 19th; MEETING ON NUCLEAR INDUSTRY, 4th |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
LAINETTI, ELIZABETH B.F. SOARES, CARLOS R.J. NASCIMENTO, NANCI do INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 12th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 19th; MEETING ON NUCLEAR INDUSTRY, 4th |
dc.subject.por.fl_str_mv |
proposals animals mammals equipment radiopharmaceuticals drugs |
topic |
proposals animals mammals equipment radiopharmaceuticals drugs |
description |
The use of Animal House Facilities of IPEN-CNEN/SP has provided rats and mice with controlled sanitary quality for research and quality control in the production of radiopharmaceuticals lots, produced at IPEN, following rules of CONCEA ??? Brazilian National Council for Animal Experimentation Control and approved in Ethics Committee on the Use of Animals (CEUA), before they be sent to hospitals and clinics spread out in Brazil, for use in Nuclear Medicine. The production and the supply of high quality laboratory animals have fundamental importance for the accomplishment of vanguard scientific research, with reproducibility and universality. The quality of those animals depends, largely, of the available facilities for their production and lodging, to assure the demanded sanitary control and animal???s welfare, in agreement with the ethical principles that control the activity. Therefore, the facilities design is of vital importance so that the mentioned requirements can be reached. Nevertheless, pigs and miniature pigs have gained importance as large animal models in medicine. With their size, organ capacity, and physiology resembling in several aspects that of humans, pigs are well suited for preclinical experiments and long-term safety studies. The minipigs will be used for preclinical testing of radiopharmaceuticals and assays radioactive materials for cardiac tests. This paper describes the premises and preliminary activities that have been performed at IPEN for the design of new Animal House Facilities dedicated to keeping minipigs taking into account fundamental aspects such as: animal???s welfare, sanitation, genetic, in agreement with the ethical principles that control the activity and environmental concerns. |
publishDate |
2016 |
dc.date.evento.pt_BR.fl_str_mv |
October 4-9, 2015 |
dc.date.accessioned.fl_str_mv |
2016-11-14T13:09:34Z |
dc.date.available.fl_str_mv |
2016-11-14T13:09:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ipen.br/handle/123456789/26841 |
url |
http://repositorio.ipen.br/handle/123456789/26841 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.coverage.pt_BR.fl_str_mv |
I |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional do IPEN instname:Instituto de Pesquisas Energéticas e Nucleares (IPEN) instacron:IPEN |
instname_str |
Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
instacron_str |
IPEN |
institution |
IPEN |
reponame_str |
Repositório Institucional do IPEN |
collection |
Repositório Institucional do IPEN |
bitstream.url.fl_str_mv |
http://repositorio.ipen.br/bitstream/123456789/26841/1/22638.pdf http://repositorio.ipen.br/bitstream/123456789/26841/2/license.txt |
bitstream.checksum.fl_str_mv |
6c400f353a7b8d925551f877c38f8074 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
repository.mail.fl_str_mv |
bibl@ipen.br |
_version_ |
1767254240018825216 |