Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission

• Autor(a) principal: Quintans-Júnior,Lucindo J.
• Data de Publicação: 2009
• Outros Autores: Silva,Davi A., Siqueira,Jullyana S., Araújo,Adriano A.S., Guimarães,Adriana G., Araújo,Rafael A.N., Araújo,Demétrius A.M., Souza,Maria de Fátima V., Gutierrez,Stanley J.C., Barbosa-Filho,José M., Almeida,Reinaldo N.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of epilepsy and clinical neurophysiology (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492009000400005
• topic: N-salicyloyltryptamine; anticonvulsant; PTZ; flumazenil; GABA A

AIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABA A-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism.