Pre-surgical mood disorders associated to worse post-surgical seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis

• Autor(a) principal: Araújo Filho,Gerardo Maria de
• Data de Publicação: 2012
• Outros Autores: Gomes,Francinaldo Lobato, Mazetto,Lenon, Marinho,Murilo Martinez, Tavares,Igor Melo, Caboclo,Luís Otávio Sales Ferreira, Yacubian,Elza Márcia Targas, Centeno,Ricardo Silva
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of epilepsy and clinical neurophysiology (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000100006
• topic: Temporal lobe epilepsy; mesial temporal sclerosis; epilepsy surgery; psychiatric disorders; seizure outcome

OBJECTIVES: This study aims at verifying the impact of pre-surgical PD on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). METHODS: After previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) TLE-MTS patients (65 females; 56.5%) were analyzed. Psychiatric evaluations were performed through DSM-IV criteria. Engel IA was established as a favorable prognosis. RESULTS: Forty-five patients (41.6%) were classified as Engel IA, while 47 (40.8%) presented pre-surgical PD. Depression (OR=5.11; p=0.004) appeared as a risk factor associated to a non-favorable seizure outcome. CONCLUSION: In patients with refractory TLE-MTS, the presence of depression predicts an unfavorable outcome.