Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/3014 |
Resumo: | Metabolic syndrome (MS) is defined as the grouping of risk factors that alter homeostasis, having as a unifying mechanism the inflammatory process. The pathophysiology of MS is not yet fully understood, but the factors that are related to the accumulation of visceral fat and Insulin resistance (IR) are characteristic of this condition. Osteocalcin (OC) has been studied because it plays an important role in glucose metabolism. It has recently been found that treatment with Galantamine modulated the sympatho-vagal system, in addition, decreased circulating insulin levels and improved to IR, as measured by the HOMA index. Our objective was to verify the effect of this treatment on metabolic, inflammatory, and aging markers. We found that administration of Galantamine increased undercarboxylated osteocalcin (OCd) levels in the treated group (9.61 ± 6.79 vs. 11.33 ± 7.37 pg/mL) and correlated with improvement in the sympatho-vagal balance (R²= 0.075 p= 0.036), the treatment was also able to decrease sCD40L levels in the treated group (5102.92 ± 4474.54 vs 1756.06 ± 2542.07 pg/mL), decreased levels of Leptin (33.34 ± 23.1 vs 25.69 ± 18.13 ng/mL) and showed an increase in Adiponectin (8.88 ± 2.1 vs 9.77 ± 2.64 μg/mL). We demonstrated a positive correlation of klotho with OCd levels (R²= 0.100 p= 0.049). Taken together, these data demonstrate that increased cholinergic stimulation improves the metabolic, inflammatory and energetic profile in MS patients. Future studies are needed to elucidate the impact of these changes on the development of cardiovascular diseases and to consolidate cholinergic stimulation as a potential therapeutic target in MS. |
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Consolim-Colombo, Fernanda Marcianohttp://lattes.cnpq.br/8102854014364848Moysés, Rosa Maria Affonsohttp://lattes.cnpq.br/7503896254471304Consolim-Colombo, Fernanda Marcianohttp://lattes.cnpq.br/8102854014364848Michelini, Lisete Compagnohttp://lattes.cnpq.br/7970704932733980Dalboni, Maria Aparecidahttp://lattes.cnpq.br/9818040147487320http://lattes.cnpq.br/0139236208859633Katayama, Keyla Yukari2022-07-27T19:06:55Z2017-02-22Katayama, Keyla Yukari. Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica. 2017. 91 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/3014Metabolic syndrome (MS) is defined as the grouping of risk factors that alter homeostasis, having as a unifying mechanism the inflammatory process. The pathophysiology of MS is not yet fully understood, but the factors that are related to the accumulation of visceral fat and Insulin resistance (IR) are characteristic of this condition. Osteocalcin (OC) has been studied because it plays an important role in glucose metabolism. It has recently been found that treatment with Galantamine modulated the sympatho-vagal system, in addition, decreased circulating insulin levels and improved to IR, as measured by the HOMA index. Our objective was to verify the effect of this treatment on metabolic, inflammatory, and aging markers. We found that administration of Galantamine increased undercarboxylated osteocalcin (OCd) levels in the treated group (9.61 ± 6.79 vs. 11.33 ± 7.37 pg/mL) and correlated with improvement in the sympatho-vagal balance (R²= 0.075 p= 0.036), the treatment was also able to decrease sCD40L levels in the treated group (5102.92 ± 4474.54 vs 1756.06 ± 2542.07 pg/mL), decreased levels of Leptin (33.34 ± 23.1 vs 25.69 ± 18.13 ng/mL) and showed an increase in Adiponectin (8.88 ± 2.1 vs 9.77 ± 2.64 μg/mL). We demonstrated a positive correlation of klotho with OCd levels (R²= 0.100 p= 0.049). Taken together, these data demonstrate that increased cholinergic stimulation improves the metabolic, inflammatory and energetic profile in MS patients. Future studies are needed to elucidate the impact of these changes on the development of cardiovascular diseases and to consolidate cholinergic stimulation as a potential therapeutic target in MS.A síndrome metabólica (SM) é definida como o agrupamento de fatores de risco que alteram a homeostase, tendo como mecanismo unificador, o processo inflamatório. A fisiopatologia da SM ainda não é totalmente conhecida, mas os fatores que estão relacionados ao acúmulo de gordura visceral e a resistência à Insulina (RI), são característicos dessa condição. A Osteocalcina (OC) tem sido alvo de estudos por ter um papel importante no metabolismo da glicose. Recentemente foi verificado que o tratamento com a Galantamina, modulou o sistema simpato-vagal, além disso, diminuiu os níveis de insulina circulantes e melhorou à RI, aferida pelo índice HOMA. Nosso objetivo foi verificar o efeito desse tratamento sobre marcadores metabólicos, inflamatórios, e de envelhecimento. Verificamos que a administração de Galantamina aumentou os níveis de osteocalcina descarboxilada (OCd) no grupo tratado (9,61±6,79 vs 11,33±7,37 pg/mL) e a mesma foi correlacionada com a melhora do balanço simpato-vagal (R²=0,075 p=0,036), o tratamento também foi capaz de diminuir os níveis do sCD40L no grupo tratado (5102,92±4474,54 vs 1756,06±2542,07 pg/mL), diminuiu os níveis de Leptina (33,34±23,1 vs 25,69±18,13ng/mL) e demonstrou um aumento da Adiponectina (8,88±2,1 vs 9,77±2,64 µg/mL). Demonstramos correlação positiva do klotho com os níveis de OCd (R²=0,100 p=0,049). Em conjunto, esses dados demonstram que o aumento da estimulação colinérgica melhora o perfil metabólico, inflamatório e energético em pacientes com SM. Futuros estudos são necessários para elucidar o impacto dessas alterações no desenvolvimento das doenças cardiovasculares e consolidar a estimulação colinérgica como potencial alvo terapêutico na SM.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2022-07-27T19:06:55Z No. of bitstreams: 1 Keyla Yukari Katayama.pdf: 1241542 bytes, checksum: 13d7a19394c0f4114f7be195b0b498fb (MD5)Made available in DSpace on 2022-07-27T19:06:55Z (GMT). No. of bitstreams: 1 Keyla Yukari Katayama.pdf: 1241542 bytes, checksum: 13d7a19394c0f4114f7be195b0b498fb (MD5) Previous issue date: 2017-02-22application/pdfporUniversidade Nove de JulhoPrograma de Mestrado em MedicinaUNINOVEBrasilSaúdesíndrome metabólicaanticolinesterásico galantaminaklothoosteocalcina descarboxiladasCD40Lmetabolic syndromeanticholinesterase galantamineklothoundercarboxylated osteocalcinsCD40LCIENCIAS DA SAUDEEfeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólicaEffect of anticholinesterase galantamine on metabolic, inflammatory and aging parameters in patients with metabolic syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALKeyla Yukari Katayama.pdfKeyla Yukari Katayama.pdfapplication/pdf1241542http://localhost:8080/tede/bitstream/tede/3014/2/Keyla+Yukari+Katayama.pdf13d7a19394c0f4114f7be195b0b498fbMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/3014/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/30142022-07-27 16:06:55.69oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2022-07-27T19:06:55Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica |
dc.title.alternative.eng.fl_str_mv |
Effect of anticholinesterase galantamine on metabolic, inflammatory and aging parameters in patients with metabolic syndrome |
title |
Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica |
spellingShingle |
Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica Katayama, Keyla Yukari síndrome metabólica anticolinesterásico galantamina klotho osteocalcina descarboxilada sCD40L metabolic syndrome anticholinesterase galantamine klotho undercarboxylated osteocalcin sCD40L CIENCIAS DA SAUDE |
title_short |
Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica |
title_full |
Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica |
title_fullStr |
Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica |
title_full_unstemmed |
Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica |
title_sort |
Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica |
author |
Katayama, Keyla Yukari |
author_facet |
Katayama, Keyla Yukari |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Consolim-Colombo, Fernanda Marciano |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8102854014364848 |
dc.contributor.advisor-co1.fl_str_mv |
Moysés, Rosa Maria Affonso |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/7503896254471304 |
dc.contributor.referee1.fl_str_mv |
Consolim-Colombo, Fernanda Marciano |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/8102854014364848 |
dc.contributor.referee2.fl_str_mv |
Michelini, Lisete Compagno |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7970704932733980 |
dc.contributor.referee3.fl_str_mv |
Dalboni, Maria Aparecida |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/9818040147487320 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0139236208859633 |
dc.contributor.author.fl_str_mv |
Katayama, Keyla Yukari |
contributor_str_mv |
Consolim-Colombo, Fernanda Marciano Moysés, Rosa Maria Affonso Consolim-Colombo, Fernanda Marciano Michelini, Lisete Compagno Dalboni, Maria Aparecida |
dc.subject.por.fl_str_mv |
síndrome metabólica anticolinesterásico galantamina klotho osteocalcina descarboxilada sCD40L |
topic |
síndrome metabólica anticolinesterásico galantamina klotho osteocalcina descarboxilada sCD40L metabolic syndrome anticholinesterase galantamine klotho undercarboxylated osteocalcin sCD40L CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
metabolic syndrome anticholinesterase galantamine klotho undercarboxylated osteocalcin sCD40L |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Metabolic syndrome (MS) is defined as the grouping of risk factors that alter homeostasis, having as a unifying mechanism the inflammatory process. The pathophysiology of MS is not yet fully understood, but the factors that are related to the accumulation of visceral fat and Insulin resistance (IR) are characteristic of this condition. Osteocalcin (OC) has been studied because it plays an important role in glucose metabolism. It has recently been found that treatment with Galantamine modulated the sympatho-vagal system, in addition, decreased circulating insulin levels and improved to IR, as measured by the HOMA index. Our objective was to verify the effect of this treatment on metabolic, inflammatory, and aging markers. We found that administration of Galantamine increased undercarboxylated osteocalcin (OCd) levels in the treated group (9.61 ± 6.79 vs. 11.33 ± 7.37 pg/mL) and correlated with improvement in the sympatho-vagal balance (R²= 0.075 p= 0.036), the treatment was also able to decrease sCD40L levels in the treated group (5102.92 ± 4474.54 vs 1756.06 ± 2542.07 pg/mL), decreased levels of Leptin (33.34 ± 23.1 vs 25.69 ± 18.13 ng/mL) and showed an increase in Adiponectin (8.88 ± 2.1 vs 9.77 ± 2.64 μg/mL). We demonstrated a positive correlation of klotho with OCd levels (R²= 0.100 p= 0.049). Taken together, these data demonstrate that increased cholinergic stimulation improves the metabolic, inflammatory and energetic profile in MS patients. Future studies are needed to elucidate the impact of these changes on the development of cardiovascular diseases and to consolidate cholinergic stimulation as a potential therapeutic target in MS. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-02-22 |
dc.date.accessioned.fl_str_mv |
2022-07-27T19:06:55Z |
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Katayama, Keyla Yukari. Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica. 2017. 91 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/3014 |
identifier_str_mv |
Katayama, Keyla Yukari. Efeito do anticolinesterásico galantamina em parâmetros metabólicos, inflamatórios e de envelhecimento, em portadores de síndrome metabólica. 2017. 91 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/3014 |
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por |
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8765449414823306929 |
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