Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Nutrição |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732018000500455 |
Resumo: | ABSTRACT Objective To analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fibrosis patients. Methods A cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-α, IL-1β, IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. Results Twenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-α was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1β and IL-6 was observed (p<0.05). Conclusion The pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosis |
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Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patientsAdolescentChildCystic fibrosisCytokinesErythrocytesFatty acidsABSTRACT Objective To analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fibrosis patients. Methods A cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-α, IL-1β, IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. Results Twenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-α was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1β and IL-6 was observed (p<0.05). Conclusion The pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosisPontifícia Universidade Católica de Campinas2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732018000500455Revista de Nutrição v.31 n.5 2018reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMP10.1590/1678-98652018000500003info:eu-repo/semantics/openAccessCUNHA,Ana Lucia Pereira daCOSTA,Ana Carolina Carioca daVASCONCELOS,ZiltonTAVARES DO CARMO,Maria das GraçasCHAVES,Celia Regina Moutinho de Mirandaeng2018-12-20T00:00:00Zoai:scielo:S1415-52732018000500455Revistahttp://www.scielo.br/rnONGhttps://old.scielo.br/oai/scielo-oai.php||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2018-12-20T00:00Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients |
title |
Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients |
spellingShingle |
Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients CUNHA,Ana Lucia Pereira da Adolescent Child Cystic fibrosis Cytokines Erythrocytes Fatty acids |
title_short |
Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients |
title_full |
Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients |
title_fullStr |
Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients |
title_full_unstemmed |
Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients |
title_sort |
Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients |
author |
CUNHA,Ana Lucia Pereira da |
author_facet |
CUNHA,Ana Lucia Pereira da COSTA,Ana Carolina Carioca da VASCONCELOS,Zilton TAVARES DO CARMO,Maria das Graças CHAVES,Celia Regina Moutinho de Miranda |
author_role |
author |
author2 |
COSTA,Ana Carolina Carioca da VASCONCELOS,Zilton TAVARES DO CARMO,Maria das Graças CHAVES,Celia Regina Moutinho de Miranda |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
CUNHA,Ana Lucia Pereira da COSTA,Ana Carolina Carioca da VASCONCELOS,Zilton TAVARES DO CARMO,Maria das Graças CHAVES,Celia Regina Moutinho de Miranda |
dc.subject.por.fl_str_mv |
Adolescent Child Cystic fibrosis Cytokines Erythrocytes Fatty acids |
topic |
Adolescent Child Cystic fibrosis Cytokines Erythrocytes Fatty acids |
description |
ABSTRACT Objective To analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fibrosis patients. Methods A cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-α, IL-1β, IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. Results Twenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-α was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1β and IL-6 was observed (p<0.05). Conclusion The pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosis |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732018000500455 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732018000500455 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-98652018000500003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Pontifícia Universidade Católica de Campinas |
publisher.none.fl_str_mv |
Pontifícia Universidade Católica de Campinas |
dc.source.none.fl_str_mv |
Revista de Nutrição v.31 n.5 2018 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
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1752128820136116224 |