Prevention of Alzheimer’s disease: The role of the Mediterranean diet
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/8265 |
Resumo: | Alzheimer’s disease rates have been increasing exponentially and are now considered a 21st century epidemic. It contributes substantially to the morbidity and mortality of older adults. Thus, Alzheimer’s disease is a growing major public health concern with a profuse socioeconomic impact. In addition, the existing pharmacological agents only offer modest symptomatic relief and can neither address the progressive neurodegeneration nor cure the disease. Therefore, finding effective preventive and therapeutic measures that delay the onset or reverse the course of the disease is crucial. Several studies have shown that lifestyle factors may play a central role in reducing the risk of developing Alzheimer’s disease or, at least, in delaying its clinical symptoms. Amongthese disease-modifying factors, healthy nutrition has drawn much attention given that it might strongly influence the risk of cognitive decline, dementia, and Alzheimer’s disease. Such healthy dietary pattern is the Mediterranean diet. The Mediterranean diet may play a protective role against age-related changes in cognitive function, pre-dementia syndromes, and dementia. Therefore, it may constitute an effective preventive strategy for Alzheimer’s disease, with low costs and few side effects. Importantly, these promising preventive measures may translate into strong epidemiological health outcomes, which might lead to a significant progress in public health. An online search was conducted in PubMed in order to revise the literature concerning the association between diet and dementia, specifically, if a higher adherence to the Mediterranean diet pattern is related to lower risk of developing Alzheimer’s disease, and to understand the possible mechanisms that may explain such association. |
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Prevention of Alzheimer’s disease: The role of the Mediterranean dietPrevenção da doença de Alzheimer: o papel da dieta MediterrânicaAlzheimer diseaseDietMediterranean dietPreventionDoença de AlzheimerDietaDieta mediterrânicaPrevenção de doençasAlzheimer’s disease rates have been increasing exponentially and are now considered a 21st century epidemic. It contributes substantially to the morbidity and mortality of older adults. Thus, Alzheimer’s disease is a growing major public health concern with a profuse socioeconomic impact. In addition, the existing pharmacological agents only offer modest symptomatic relief and can neither address the progressive neurodegeneration nor cure the disease. Therefore, finding effective preventive and therapeutic measures that delay the onset or reverse the course of the disease is crucial. Several studies have shown that lifestyle factors may play a central role in reducing the risk of developing Alzheimer’s disease or, at least, in delaying its clinical symptoms. Amongthese disease-modifying factors, healthy nutrition has drawn much attention given that it might strongly influence the risk of cognitive decline, dementia, and Alzheimer’s disease. Such healthy dietary pattern is the Mediterranean diet. The Mediterranean diet may play a protective role against age-related changes in cognitive function, pre-dementia syndromes, and dementia. Therefore, it may constitute an effective preventive strategy for Alzheimer’s disease, with low costs and few side effects. Importantly, these promising preventive measures may translate into strong epidemiological health outcomes, which might lead to a significant progress in public health. An online search was conducted in PubMed in order to revise the literature concerning the association between diet and dementia, specifically, if a higher adherence to the Mediterranean diet pattern is related to lower risk of developing Alzheimer’s disease, and to understand the possible mechanisms that may explain such association.A doença de Alzheimer tem vindo a aumentar exponencialmente, sendo atualmente considerada uma das epidemias do século XXI e contribuindo significativamente para a morbilidade e mortalidade observadas napopulação idosa. Assim, é um importante problema de saúde pública, com um impacto socioeconômico crescente. Os fármacos usados atualmente apenas contribuem para o alívio sintomático e não atuam no nível do processo neurodegenerativo nem curam a doença. Desse modo, desenvolver medidas preventivas e terapêuticas que sejam eficazes em atrasar ou em reverter o curso da doença é de extrema importância. Vários estudos têm demonstrado que fatores relacionados com o estilo de vida desempenham um papel central em reduzir o risco de desenvolver doença de Alzheimer ou, pelo menos, em atrasar o aparecimento dos sintomas. Um desses fatores é a nutrição, que influencia significativamente o risco de declínio cognitivo, demência e doença de Alzheimer. Um desses padrões dietéticos é a dieta Mediterrânica, que desempenha papel protetor nas alterações da função cognitiva, síndromes pré-demenciais e demência, e, portanto, poderá representar uma estratégia preventiva eficaz para a doença de Alzheimer, com baixos custos e escassos efeitos colaterais. Essas medidas preventivas promissoras poderão resultar em dados epidemiológicos importantes, o que poderá traduzir-se num progresso significativo na saúde pública. Foi efetuada uma pesquisa na PubMed de artigos acerca da associação entre alimentação e demência e, especificamente, acerca da associação entre uma maior adesão à dieta Mediterrânica e o menor risco de desenvolver doença de Alzheimer assim como a verificação de quais os potenciais mecanismos que explicam essa associação. Núcleo de Editoração – PUC-Campinas2023-04-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8265Brazilian Journal of Nutrition; Vol. 28 No. 6 (2015): Revista de NutriçãoRevista de Nutrição; Vol. 28 Núm. 6 (2015): Revista de NutriçãoRevista de Nutrição; v. 28 n. 6 (2015): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPenghttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8265/5788Copyright (c) 2023 Maria João SOUSA, Joana GUIMARÃEShttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSOUSA, Maria João GUIMARÃES, Joana 2023-04-05T18:07:06Zoai:ojs.periodicos.puc-campinas.edu.br:article/8265Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-04-05T18:07:06Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Prevention of Alzheimer’s disease: The role of the Mediterranean diet Prevenção da doença de Alzheimer: o papel da dieta Mediterrânica |
title |
Prevention of Alzheimer’s disease: The role of the Mediterranean diet |
spellingShingle |
Prevention of Alzheimer’s disease: The role of the Mediterranean diet SOUSA, Maria João Alzheimer disease Diet Mediterranean diet Prevention Doença de Alzheimer Dieta Dieta mediterrânica Prevenção de doenças |
title_short |
Prevention of Alzheimer’s disease: The role of the Mediterranean diet |
title_full |
Prevention of Alzheimer’s disease: The role of the Mediterranean diet |
title_fullStr |
Prevention of Alzheimer’s disease: The role of the Mediterranean diet |
title_full_unstemmed |
Prevention of Alzheimer’s disease: The role of the Mediterranean diet |
title_sort |
Prevention of Alzheimer’s disease: The role of the Mediterranean diet |
author |
SOUSA, Maria João |
author_facet |
SOUSA, Maria João GUIMARÃES, Joana |
author_role |
author |
author2 |
GUIMARÃES, Joana |
author2_role |
author |
dc.contributor.author.fl_str_mv |
SOUSA, Maria João GUIMARÃES, Joana |
dc.subject.por.fl_str_mv |
Alzheimer disease Diet Mediterranean diet Prevention Doença de Alzheimer Dieta Dieta mediterrânica Prevenção de doenças |
topic |
Alzheimer disease Diet Mediterranean diet Prevention Doença de Alzheimer Dieta Dieta mediterrânica Prevenção de doenças |
description |
Alzheimer’s disease rates have been increasing exponentially and are now considered a 21st century epidemic. It contributes substantially to the morbidity and mortality of older adults. Thus, Alzheimer’s disease is a growing major public health concern with a profuse socioeconomic impact. In addition, the existing pharmacological agents only offer modest symptomatic relief and can neither address the progressive neurodegeneration nor cure the disease. Therefore, finding effective preventive and therapeutic measures that delay the onset or reverse the course of the disease is crucial. Several studies have shown that lifestyle factors may play a central role in reducing the risk of developing Alzheimer’s disease or, at least, in delaying its clinical symptoms. Amongthese disease-modifying factors, healthy nutrition has drawn much attention given that it might strongly influence the risk of cognitive decline, dementia, and Alzheimer’s disease. Such healthy dietary pattern is the Mediterranean diet. The Mediterranean diet may play a protective role against age-related changes in cognitive function, pre-dementia syndromes, and dementia. Therefore, it may constitute an effective preventive strategy for Alzheimer’s disease, with low costs and few side effects. Importantly, these promising preventive measures may translate into strong epidemiological health outcomes, which might lead to a significant progress in public health. An online search was conducted in PubMed in order to revise the literature concerning the association between diet and dementia, specifically, if a higher adherence to the Mediterranean diet pattern is related to lower risk of developing Alzheimer’s disease, and to understand the possible mechanisms that may explain such association. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/8265 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/8265 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/8265/5788 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Maria João SOUSA, Joana GUIMARÃES https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Maria João SOUSA, Joana GUIMARÃES https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 28 No. 6 (2015): Revista de Nutrição Revista de Nutrição; Vol. 28 Núm. 6 (2015): Revista de Nutrição Revista de Nutrição; v. 28 n. 6 (2015): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
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1799126069576466432 |