Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da PUC_RS |
Texto Completo: | http://tede2.pucrs.br/tede2/handle/tede/9318 |
Resumo: | Introduction: Sepsis remains a high mortality disease worldwide. Prognostic markers are useful tools for targeting resources, indicating close monitoring or predicting early deterioration. Objective: To evaluate the prognostic performance of serum ferritin alone and in comparison with the Paediatric Index of Mortality 2 (PIM2) score, lactate, c-reactive protein (CRP) and total leukocytes in patients admitted to the Pediatric Intensive Care Unit (PICU). ) from a middle-income country with a high prevalence of iron deficiency anemia. Methods: Retrospective study conducted in a tertiary PICU in Brazil. Patients aged 6 months to 18 years admitted between June 2013 and January 2017 with a diagnosis of sepsis were selected. Ferritin and CRP values were collected in the first 48 hours, and lactate and leukocyte values in the first 24 hours after PICU admission. A detailed analysis was performed for serum ferritin. Demographic, clinical and outcome characteristics were collected from all patients and prognostic markers were compared using ROC curves and cutoff points obtained by the Youden Index. Results: During the study period there were 1407 admissions. Of these, 350 met the inclusion criteria. Ferritin was obtained from 312 patients and proved to be a good prognostic marker. Ferritin values were lower than previous studies, probably due to the high prevalence of iron deficiency anemia. Comparing the prognostic markers, PIM2, ferritin and lactate had similar performance. The PCR was slightly lower. The total leukocyte value was not useful as a prognostic marker. Conclusion: PIM2, ferritin, lactate and CRP showed good prognostic performance in patients with sepsis admitted to our PICU sample. The total leukocyte value was not useful for this purpose. |
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Garcia, Pedro Celiny Ramoshttp://lattes.cnpq.br/0761993714239641http://lattes.cnpq.br/1611686487764177Tonial, Cristian Tedesco2020-11-04T14:18:06Z2020-01-22http://tede2.pucrs.br/tede2/handle/tede/9318Introduction: Sepsis remains a high mortality disease worldwide. Prognostic markers are useful tools for targeting resources, indicating close monitoring or predicting early deterioration. Objective: To evaluate the prognostic performance of serum ferritin alone and in comparison with the Paediatric Index of Mortality 2 (PIM2) score, lactate, c-reactive protein (CRP) and total leukocytes in patients admitted to the Pediatric Intensive Care Unit (PICU). ) from a middle-income country with a high prevalence of iron deficiency anemia. Methods: Retrospective study conducted in a tertiary PICU in Brazil. Patients aged 6 months to 18 years admitted between June 2013 and January 2017 with a diagnosis of sepsis were selected. Ferritin and CRP values were collected in the first 48 hours, and lactate and leukocyte values in the first 24 hours after PICU admission. A detailed analysis was performed for serum ferritin. Demographic, clinical and outcome characteristics were collected from all patients and prognostic markers were compared using ROC curves and cutoff points obtained by the Youden Index. Results: During the study period there were 1407 admissions. Of these, 350 met the inclusion criteria. Ferritin was obtained from 312 patients and proved to be a good prognostic marker. Ferritin values were lower than previous studies, probably due to the high prevalence of iron deficiency anemia. Comparing the prognostic markers, PIM2, ferritin and lactate had similar performance. The PCR was slightly lower. The total leukocyte value was not useful as a prognostic marker. Conclusion: PIM2, ferritin, lactate and CRP showed good prognostic performance in patients with sepsis admitted to our PICU sample. The total leukocyte value was not useful for this purpose.Introdu??o: A sepse continua sendo uma doen?a de alta mortalidade no mundo. Marcadores progn?sticos s?o ferramentas ?teis para direcionar recursos, indicar uma monitoriza??o mais rigorosa ou prever uma deteriora??o precoce. Objetivo: Avaliar o desempenho progn?stico da ferritina s?rica de forma isolada e em compara??o com o escore Paediatric Index of Mortality 2 (PIM2), lactato, prote?na c-reativa (PCR) e leuc?citos totais em pacientes internados em Unidade de Terapia Intensiva Pedi?trica (UTIP) de um pa?s de renda m?dia com alta a preval?ncia de anemia ferropriva. M?todos: Estudo retrospectivo desenvolvido em uma UTIP terci?ria do Brasil. Foram selecionados pacientes de 6 meses a 18 anos internados entre junho de 2013 e janeiro de 2017 com diagn?stico de sepse. Foram coletados os valores de ferritina e PCR nas primeiras 48 horas, e valores de lactato e leuc?citos nas primeiras 24 hora ap?s a admiss?o na UTIP. Uma an?lise detalhada foi realizada para a ferritina s?rica. Caracter?sticas demogr?ficas, cl?nicas e desfechos foram coletados de todos os pacientes e os marcadores progn?sticos foram comparados atrav?s de curvas ROC e pontos de corte obtidos pelo Index de Youden. Resultados: Durante o per?odo do estudo houve 1407 admiss?es. Destes, 350 preencheram os crit?rios de inclus?o. Ferritina foi obtida em 312 pacientes e demonstrou ser um bom marcador progn?stico. Os valores de ferritina foram inferiores aos de estudos pr?vios, provavelmente pela alta preval?ncia de anemia ferropriva. Em rela??o a compara??o entre os marcadores progn?sticos, PIM2, ferritina e lactato tiveram desempenho semelhantes. O PCR foi ligeiramente inferior. O valor dos leuc?citos totais n?o foi ?til como marcador progn?stico. Conclus?o: PIM2, ferritina, lactato e PCR apresentaram bom desempenho progn?stico em pacientes com sepse internados na UTIP. O valor dos leuc?citos totais n?o foi ?til para esta finalidade.Submitted by PPG Pediatria e Sa?de da Crian?a (pediatria-pg@pucrs.br) on 2020-06-24T18:22:53Z No. of bitstreams: 1 Tese Cristian Tonial 19.02.20 v5.pdf: 3992183 bytes, checksum: ba44caea918cd10390579dad98c51a83 (MD5)Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2020-11-04T14:11:15Z (GMT) No. of bitstreams: 1 Tese Cristian Tonial 19.02.20 v5.pdf: 3992183 bytes, checksum: ba44caea918cd10390579dad98c51a83 (MD5)Made available in DSpace on 2020-11-04T14:18:06Z (GMT). No. of bitstreams: 1 Tese Cristian Tonial 19.02.20 v5.pdf: 3992183 bytes, checksum: ba44caea918cd10390579dad98c51a83 (MD5) Previous issue date: 2020-01-22application/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/179287/TES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em Medicina/Pediatria e Sa?de da Crian?aPUCRSBrasilEscola de MedicinaFerritinaMortalidadeSepseUnidades de Terapia Intensiva Pedi?tricaBiomarcadoresProgn?sticoFerritinMortalitySepsisIntensive Care UnitsPediatricBiomarkersPrognosisCIENCIAS DA SAUDE::MEDICINAMEDICINA::SAUDE MATERNO-INFANTILDesempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?tricainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisTrabalho ser? publicado como artigo ou livro60 meses04/11/2025557290555552975733500500500600-224747486637135387-969369452308786627-8067417953925345752info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILTES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdf.jpgTES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdf.jpgimage/jpeg4087http://tede2.pucrs.br/tede2/bitstream/tede/9318/4/TES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdf.jpgdda5a0693389133b034ebaf20fd32b10MD54TEXTTES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdf.txtTES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdf.txttext/plain1871http://tede2.pucrs.br/tede2/bitstream/tede/9318/3/TES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdf.txtc79bdca7b15cbcdd4d427da12cf43a44MD53ORIGINALTES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdfTES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdfapplication/pdf579455http://tede2.pucrs.br/tede2/bitstream/tede/9318/2/TES_CRISTIAN_TEDESCO_TONIAL_CONFIDENCIAL.pdfb9e9525a49cf57a88e90d3c40d4475a2MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8590http://tede2.pucrs.br/tede2/bitstream/tede/9318/1/license.txt220e11f2d3ba5354f917c7035aadef24MD51tede/93182020-11-04 20:00:08.245oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2020-11-04T22:00:08Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica |
title |
Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica |
spellingShingle |
Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica Tonial, Cristian Tedesco Ferritina Mortalidade Sepse Unidades de Terapia Intensiva Pedi?trica Biomarcadores Progn?stico Ferritin Mortality Sepsis Intensive Care Units Pediatric Biomarkers Prognosis CIENCIAS DA SAUDE::MEDICINA MEDICINA::SAUDE MATERNO-INFANTIL |
title_short |
Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica |
title_full |
Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica |
title_fullStr |
Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica |
title_full_unstemmed |
Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica |
title_sort |
Desempenho progn?stico da ferritina s?rica em pacientes pedi?tricos com sepse admitidos na Unidade de Terapia Intensiva Pedi?trica |
author |
Tonial, Cristian Tedesco |
author_facet |
Tonial, Cristian Tedesco |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Garcia, Pedro Celiny Ramos |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0761993714239641 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1611686487764177 |
dc.contributor.author.fl_str_mv |
Tonial, Cristian Tedesco |
contributor_str_mv |
Garcia, Pedro Celiny Ramos |
dc.subject.por.fl_str_mv |
Ferritina Mortalidade Sepse Unidades de Terapia Intensiva Pedi?trica Biomarcadores Progn?stico |
topic |
Ferritina Mortalidade Sepse Unidades de Terapia Intensiva Pedi?trica Biomarcadores Progn?stico Ferritin Mortality Sepsis Intensive Care Units Pediatric Biomarkers Prognosis CIENCIAS DA SAUDE::MEDICINA MEDICINA::SAUDE MATERNO-INFANTIL |
dc.subject.eng.fl_str_mv |
Ferritin Mortality Sepsis Intensive Care Units Pediatric Biomarkers Prognosis |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA MEDICINA::SAUDE MATERNO-INFANTIL |
description |
Introduction: Sepsis remains a high mortality disease worldwide. Prognostic markers are useful tools for targeting resources, indicating close monitoring or predicting early deterioration. Objective: To evaluate the prognostic performance of serum ferritin alone and in comparison with the Paediatric Index of Mortality 2 (PIM2) score, lactate, c-reactive protein (CRP) and total leukocytes in patients admitted to the Pediatric Intensive Care Unit (PICU). ) from a middle-income country with a high prevalence of iron deficiency anemia. Methods: Retrospective study conducted in a tertiary PICU in Brazil. Patients aged 6 months to 18 years admitted between June 2013 and January 2017 with a diagnosis of sepsis were selected. Ferritin and CRP values were collected in the first 48 hours, and lactate and leukocyte values in the first 24 hours after PICU admission. A detailed analysis was performed for serum ferritin. Demographic, clinical and outcome characteristics were collected from all patients and prognostic markers were compared using ROC curves and cutoff points obtained by the Youden Index. Results: During the study period there were 1407 admissions. Of these, 350 met the inclusion criteria. Ferritin was obtained from 312 patients and proved to be a good prognostic marker. Ferritin values were lower than previous studies, probably due to the high prevalence of iron deficiency anemia. Comparing the prognostic markers, PIM2, ferritin and lactate had similar performance. The PCR was slightly lower. The total leukocyte value was not useful as a prognostic marker. Conclusion: PIM2, ferritin, lactate and CRP showed good prognostic performance in patients with sepsis admitted to our PICU sample. The total leukocyte value was not useful for this purpose. |
publishDate |
2020 |
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2020-11-04T14:18:06Z |
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2020-01-22 |
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http://tede2.pucrs.br/tede2/handle/tede/9318 |
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por |
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por |
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557290555552975733 |
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500 500 500 600 |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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Programa de P?s-Gradua??o em Medicina/Pediatria e Sa?de da Crian?a |
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PUCRS |
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Brasil |
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Escola de Medicina |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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