Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/6556 |
Resumo: | The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries. |
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Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromiumBiomonitoringHuman BiomonitoringHexavalent chromiumOccupational ExposureEffect MarkersElectroplatingExhaled Breath CondensateMulticenter StudyWeldingGenotoxicidade AmbientalThe EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries.Highlights: Pan-European human biomonitoring (HBM) study on occupational exposure to Cr(VI); Harmonized protocols for collecting HBM, occupational hygiene and contextual data; Broad set-up to create meaningful data for EU decision making on Cr(VI) exposure; New biomarkers for exposure to Cr(VI) are piloted; Correlating different exposure parameters to understand the fate of chromium.This work has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author’s organizations and/or Ministries.Elsevier/ Academic PressRepositório Científico do Instituto Nacional de SaúdeSantonen, TiinaAlimonti, AlessandroBocca, BeatriceDuca, Radu CorneliuGalea, Karen SGodderis, LodeGöen, ThomasGomes, BrunoHanser, OgierIavicoli, IvoJanasik, BeataJones, KateKiilunen, MirjaKoch, Holger MLeese, ElizabethLeso, VerusckaLouro, HenriquetaNdaw, SophiePorras, Simo PRobert, AlainRuggieri, FlaviaScheepers, Paul T JSilva, Maria JViegas, SusanaWasowicz, WojciechCastano, ArgeliaSepai, Ovnair2020-04-29T06:11:34Z2019-07-102019-07-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6556engEnviron Res. 2019 Oct;177:108583. doi: 10.1016/j.envres.2019.108583. Epub 2019 Jul 100013-935110.1016/j.envres.2019.108583info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:27Zoai:repositorio.insa.pt:10400.18/6556Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:09.884652Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium |
title |
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium |
spellingShingle |
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium Santonen, Tiina Biomonitoring Human Biomonitoring Hexavalent chromium Occupational Exposure Effect Markers Electroplating Exhaled Breath Condensate Multicenter Study Welding Genotoxicidade Ambiental |
title_short |
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium |
title_full |
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium |
title_fullStr |
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium |
title_full_unstemmed |
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium |
title_sort |
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium |
author |
Santonen, Tiina |
author_facet |
Santonen, Tiina Alimonti, Alessandro Bocca, Beatrice Duca, Radu Corneliu Galea, Karen S Godderis, Lode Göen, Thomas Gomes, Bruno Hanser, Ogier Iavicoli, Ivo Janasik, Beata Jones, Kate Kiilunen, Mirja Koch, Holger M Leese, Elizabeth Leso, Veruscka Louro, Henriqueta Ndaw, Sophie Porras, Simo P Robert, Alain Ruggieri, Flavia Scheepers, Paul T J Silva, Maria J Viegas, Susana Wasowicz, Wojciech Castano, Argelia Sepai, Ovnair |
author_role |
author |
author2 |
Alimonti, Alessandro Bocca, Beatrice Duca, Radu Corneliu Galea, Karen S Godderis, Lode Göen, Thomas Gomes, Bruno Hanser, Ogier Iavicoli, Ivo Janasik, Beata Jones, Kate Kiilunen, Mirja Koch, Holger M Leese, Elizabeth Leso, Veruscka Louro, Henriqueta Ndaw, Sophie Porras, Simo P Robert, Alain Ruggieri, Flavia Scheepers, Paul T J Silva, Maria J Viegas, Susana Wasowicz, Wojciech Castano, Argelia Sepai, Ovnair |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Santonen, Tiina Alimonti, Alessandro Bocca, Beatrice Duca, Radu Corneliu Galea, Karen S Godderis, Lode Göen, Thomas Gomes, Bruno Hanser, Ogier Iavicoli, Ivo Janasik, Beata Jones, Kate Kiilunen, Mirja Koch, Holger M Leese, Elizabeth Leso, Veruscka Louro, Henriqueta Ndaw, Sophie Porras, Simo P Robert, Alain Ruggieri, Flavia Scheepers, Paul T J Silva, Maria J Viegas, Susana Wasowicz, Wojciech Castano, Argelia Sepai, Ovnair |
dc.subject.por.fl_str_mv |
Biomonitoring Human Biomonitoring Hexavalent chromium Occupational Exposure Effect Markers Electroplating Exhaled Breath Condensate Multicenter Study Welding Genotoxicidade Ambiental |
topic |
Biomonitoring Human Biomonitoring Hexavalent chromium Occupational Exposure Effect Markers Electroplating Exhaled Breath Condensate Multicenter Study Welding Genotoxicidade Ambiental |
description |
The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07-10 2019-07-10T00:00:00Z 2020-04-29T06:11:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6556 |
url |
http://hdl.handle.net/10400.18/6556 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environ Res. 2019 Oct;177:108583. doi: 10.1016/j.envres.2019.108583. Epub 2019 Jul 10 0013-9351 10.1016/j.envres.2019.108583 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier/ Academic Press |
publisher.none.fl_str_mv |
Elsevier/ Academic Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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