Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor
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Publication Date: | 2003 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | https://doi.org/10.1128/CDLI.10.3.446-450.2003 |
Summary: | Chlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis. Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies. |
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Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factorMONOCLONAL-ANTIBODIESHUMAN CHAPERONIN-10IDENTIFICATIONAUTOIMMUNITYPURIFICATIONALLELESCLONINGMICEMicrobiology (medical)Immunology and AllergyClinical BiochemistryImmunologyChlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis. Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBetsou, FotiniBorrego, Maria JoséGuillaume, NicolasCatry, Maria AnjosRomão, SandraMachado-Caetano, J. A.Sueur, Jean MarieMention, JacquesFaille, NicoleOrfila, Jeanne2017-09-25T22:04:06Z2003-062003-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttps://doi.org/10.1128/CDLI.10.3.446-450.2003eng1071-412XPURE: 3151616http://www.scopus.com/inward/record.url?scp=12444269960&partnerID=8YFLogxKhttps://doi.org/10.1128/CDLI.10.3.446-450.2003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:11:52Zoai:run.unl.pt:10362/23581Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:50.665656Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor |
title |
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor |
spellingShingle |
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor Betsou, Fotini MONOCLONAL-ANTIBODIES HUMAN CHAPERONIN-10 IDENTIFICATION AUTOIMMUNITY PURIFICATION ALLELES CLONING MICE Microbiology (medical) Immunology and Allergy Clinical Biochemistry Immunology |
title_short |
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor |
title_full |
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor |
title_fullStr |
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor |
title_full_unstemmed |
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor |
title_sort |
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor |
author |
Betsou, Fotini |
author_facet |
Betsou, Fotini Borrego, Maria José Guillaume, Nicolas Catry, Maria Anjos Romão, Sandra Machado-Caetano, J. A. Sueur, Jean Marie Mention, Jacques Faille, Nicole Orfila, Jeanne |
author_role |
author |
author2 |
Borrego, Maria José Guillaume, Nicolas Catry, Maria Anjos Romão, Sandra Machado-Caetano, J. A. Sueur, Jean Marie Mention, Jacques Faille, Nicole Orfila, Jeanne |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Betsou, Fotini Borrego, Maria José Guillaume, Nicolas Catry, Maria Anjos Romão, Sandra Machado-Caetano, J. A. Sueur, Jean Marie Mention, Jacques Faille, Nicole Orfila, Jeanne |
dc.subject.por.fl_str_mv |
MONOCLONAL-ANTIBODIES HUMAN CHAPERONIN-10 IDENTIFICATION AUTOIMMUNITY PURIFICATION ALLELES CLONING MICE Microbiology (medical) Immunology and Allergy Clinical Biochemistry Immunology |
topic |
MONOCLONAL-ANTIBODIES HUMAN CHAPERONIN-10 IDENTIFICATION AUTOIMMUNITY PURIFICATION ALLELES CLONING MICE Microbiology (medical) Immunology and Allergy Clinical Biochemistry Immunology |
description |
Chlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis. Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-06 2003-06-01T00:00:00Z 2017-09-25T22:04:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1128/CDLI.10.3.446-450.2003 |
url |
https://doi.org/10.1128/CDLI.10.3.446-450.2003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1071-412X PURE: 3151616 http://www.scopus.com/inward/record.url?scp=12444269960&partnerID=8YFLogxK https://doi.org/10.1128/CDLI.10.3.446-450.2003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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5 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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