Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone?
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/5781 |
Resumo: | This study was designed to evaluate whether Hybrid Capture II (HC2) test alone refer women to colposcopy as appropriately as DNA Papanicolaou (Pap) test, in the context of a high-risk group of women using the recently validated DNACitoliq LBC system. Women with suspected cervical disease were included in this crosssectional study at a tertiary center in São Paulo, Brazil, for further workup. All women had cervical material collected for LBC and HC2 for high-risk human papillomavirus (hrHPV)-DNA test. Irrespective of cytology and HC2 results, colposcopy, and cervical biopsy when applicable, was systematically performed. All tests were performed blindly. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of both methods were computed in relation to histology. A total of 1,080 women were included: 36.4% (393/1080) had ACUS+, 10.2% (110/1080) were high-grade squamous intraepithelial lesions (HSIL) or cancer. Mean age was 33.5 years. All women underwent colposcopy, and cervical biopsies were performed in 38.4% (415/1080): 33% (137/415) of the biopsies were negative, 14.4% (155/415) were low-grade squamous intraepithelial lesions (LSIL), 10.7% (116/415) were HSIL, and 0.6% (7/415) were cancer. HC2 sensitivity to diagnose biopsy-proven HSIL was 100%. Because all HSIL cases had a positive HC2 test, sensitivity could not be improved by adding LBC. Specificity and positive and negative predictive values of DNA Pap were not significantly different from HC2 test alone when considering LSIL+ histology as ‘‘gold standard’’ and HSIL+ histology. As a screening strategy for women with high-risk for cervical cancer, DNA Pap test does not seem to add substantially to HC2 alone in terms of appropriately referring to colposcopy. |
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Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone?Hybrid captureDCS systemLiquid-based cytologyPapanicolaou testCervical screeningCervical cancerScience & TechnologyThis study was designed to evaluate whether Hybrid Capture II (HC2) test alone refer women to colposcopy as appropriately as DNA Papanicolaou (Pap) test, in the context of a high-risk group of women using the recently validated DNACitoliq LBC system. Women with suspected cervical disease were included in this crosssectional study at a tertiary center in São Paulo, Brazil, for further workup. All women had cervical material collected for LBC and HC2 for high-risk human papillomavirus (hrHPV)-DNA test. Irrespective of cytology and HC2 results, colposcopy, and cervical biopsy when applicable, was systematically performed. All tests were performed blindly. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of both methods were computed in relation to histology. A total of 1,080 women were included: 36.4% (393/1080) had ACUS+, 10.2% (110/1080) were high-grade squamous intraepithelial lesions (HSIL) or cancer. Mean age was 33.5 years. All women underwent colposcopy, and cervical biopsies were performed in 38.4% (415/1080): 33% (137/415) of the biopsies were negative, 14.4% (155/415) were low-grade squamous intraepithelial lesions (LSIL), 10.7% (116/415) were HSIL, and 0.6% (7/415) were cancer. HC2 sensitivity to diagnose biopsy-proven HSIL was 100%. Because all HSIL cases had a positive HC2 test, sensitivity could not be improved by adding LBC. Specificity and positive and negative predictive values of DNA Pap were not significantly different from HC2 test alone when considering LSIL+ histology as ‘‘gold standard’’ and HSIL+ histology. As a screening strategy for women with high-risk for cervical cancer, DNA Pap test does not seem to add substantially to HC2 alone in terms of appropriately referring to colposcopy.Lippincott, Williams & WilkinsUniversidade do MinhoPereira, Sónia Maria MirandaCastelo, A.Makabe, SérgioUtagawa, Maria LúciaLoreto, Celso diMaeda, Marina Yoshiê SakamotoMarques, José A.Santoro, Carmen L. F.Longatto Filho, AdhemarDôres, Gerson B. das2006-012006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/5781eng"International journal of gynecological pathology". ISSN 0277-1691. 25:1 (Jan. 2006) 38-41.0277-169110.1097/01.pgp.0000177122.71309.7216306782info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:28:36ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone? |
title |
Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone? |
spellingShingle |
Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone? Pereira, Sónia Maria Miranda Hybrid capture DCS system Liquid-based cytology Papanicolaou test Cervical screening Cervical cancer Science & Technology |
title_short |
Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone? |
title_full |
Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone? |
title_fullStr |
Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone? |
title_full_unstemmed |
Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone? |
title_sort |
Screening for cervical Cancer in high-risk populations: DNA pap test or hybrid capture II test alone? |
author |
Pereira, Sónia Maria Miranda |
author_facet |
Pereira, Sónia Maria Miranda Castelo, A. Makabe, Sérgio Utagawa, Maria Lúcia Loreto, Celso di Maeda, Marina Yoshiê Sakamoto Marques, José A. Santoro, Carmen L. F. Longatto Filho, Adhemar Dôres, Gerson B. das |
author_role |
author |
author2 |
Castelo, A. Makabe, Sérgio Utagawa, Maria Lúcia Loreto, Celso di Maeda, Marina Yoshiê Sakamoto Marques, José A. Santoro, Carmen L. F. Longatto Filho, Adhemar Dôres, Gerson B. das |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pereira, Sónia Maria Miranda Castelo, A. Makabe, Sérgio Utagawa, Maria Lúcia Loreto, Celso di Maeda, Marina Yoshiê Sakamoto Marques, José A. Santoro, Carmen L. F. Longatto Filho, Adhemar Dôres, Gerson B. das |
dc.subject.por.fl_str_mv |
Hybrid capture DCS system Liquid-based cytology Papanicolaou test Cervical screening Cervical cancer Science & Technology |
topic |
Hybrid capture DCS system Liquid-based cytology Papanicolaou test Cervical screening Cervical cancer Science & Technology |
description |
This study was designed to evaluate whether Hybrid Capture II (HC2) test alone refer women to colposcopy as appropriately as DNA Papanicolaou (Pap) test, in the context of a high-risk group of women using the recently validated DNACitoliq LBC system. Women with suspected cervical disease were included in this crosssectional study at a tertiary center in São Paulo, Brazil, for further workup. All women had cervical material collected for LBC and HC2 for high-risk human papillomavirus (hrHPV)-DNA test. Irrespective of cytology and HC2 results, colposcopy, and cervical biopsy when applicable, was systematically performed. All tests were performed blindly. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of both methods were computed in relation to histology. A total of 1,080 women were included: 36.4% (393/1080) had ACUS+, 10.2% (110/1080) were high-grade squamous intraepithelial lesions (HSIL) or cancer. Mean age was 33.5 years. All women underwent colposcopy, and cervical biopsies were performed in 38.4% (415/1080): 33% (137/415) of the biopsies were negative, 14.4% (155/415) were low-grade squamous intraepithelial lesions (LSIL), 10.7% (116/415) were HSIL, and 0.6% (7/415) were cancer. HC2 sensitivity to diagnose biopsy-proven HSIL was 100%. Because all HSIL cases had a positive HC2 test, sensitivity could not be improved by adding LBC. Specificity and positive and negative predictive values of DNA Pap were not significantly different from HC2 test alone when considering LSIL+ histology as ‘‘gold standard’’ and HSIL+ histology. As a screening strategy for women with high-risk for cervical cancer, DNA Pap test does not seem to add substantially to HC2 alone in terms of appropriately referring to colposcopy. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-01 2006-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/5781 |
url |
http://hdl.handle.net/1822/5781 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"International journal of gynecological pathology". ISSN 0277-1691. 25:1 (Jan. 2006) 38-41. 0277-1691 10.1097/01.pgp.0000177122.71309.72 16306782 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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