Antimicrobial peptides as novel anti-tuberculosis therapeutics

Detalhes bibliográficos
Autor(a) principal: Silva, João Pedro Martins Soares Castro
Data de Publicação: 2016
Outros Autores: Appelberg, Rui, Gama, F. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/42262
Resumo: "Available online 24 May 2016"
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spelling Antimicrobial peptides as novel anti-tuberculosis therapeuticsAntimicrobial peptidesTuberculosisMycobacteriaAntibioticsPeptide marketPharmacoeconomical analysisScience & Technology"Available online 24 May 2016"Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, has recently joined HIV/AIDS as the world's deadliest infectious disease, affecting around 9.6 million people worldwide in 2014. Of those, about 1.2 million died from the disease. Resistance acquisition to existing antibiotics, with the subsequent emergence of Multi-Drug Resistant mycobacteria strains, together with an increasing economic burden, has urged the development of new anti-TB drugs. In this scope, antimicrobial peptides (AMPs), which are small, cationic and amphipathic peptides that make part of the innate immune system, now arise as promising candidates for TB treatment. In this review, we analyze the potential of AMPs for this application. We address the mechanisms of action, advantages and disadvantages over conventional antibiotics and how problems associated with its use may be overcome to boost their therapeutic potential. Additionally, we address the challenges of translational development from benchside to bedside, evaluate the current development pipeline and analyze the expected global impact from a socio-economic standpoint. The quest for more efficient and more compliant anti-TB drugs, associated with the great therapeutic potential of emerging AMPs and the rising peptide market, provide an optimal environment for the emergence of AMPs as promising therapies. Still, their pharmacological properties need to be enhanced and manufacturing-associated issues need to be addressed.Portuguese Foundation for Science and Technology (FCT) - UID/ BIO/04469/2013 unit ; COMPETE 2020 (POCI-01-0145-FEDER- 006684) ; SFRH/BPD/64958/2010Project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462)ElsevierUniversidade do MinhoSilva, João Pedro Martins Soares CastroAppelberg, RuiGama, F. M.20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/42262engSilva, João Pedro; Appelberg, Rui; Gama, F. M., Antimicrobial peptides as novel anti-tuberculosis therapeutics. Biotechnology Advances, 34(5), 924-940, 20160734-97500734-975010.1016/j.biotechadv.2016.05.00727235189http://www.journals.elsevier.com/biotechnology-advances/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:55:04ZPortal AgregadorONG
dc.title.none.fl_str_mv Antimicrobial peptides as novel anti-tuberculosis therapeutics
title Antimicrobial peptides as novel anti-tuberculosis therapeutics
spellingShingle Antimicrobial peptides as novel anti-tuberculosis therapeutics
Silva, João Pedro Martins Soares Castro
Antimicrobial peptides
Tuberculosis
Mycobacteria
Antibiotics
Peptide market
Pharmacoeconomical analysis
Science & Technology
title_short Antimicrobial peptides as novel anti-tuberculosis therapeutics
title_full Antimicrobial peptides as novel anti-tuberculosis therapeutics
title_fullStr Antimicrobial peptides as novel anti-tuberculosis therapeutics
title_full_unstemmed Antimicrobial peptides as novel anti-tuberculosis therapeutics
title_sort Antimicrobial peptides as novel anti-tuberculosis therapeutics
author Silva, João Pedro Martins Soares Castro
author_facet Silva, João Pedro Martins Soares Castro
Appelberg, Rui
Gama, F. M.
author_role author
author2 Appelberg, Rui
Gama, F. M.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, João Pedro Martins Soares Castro
Appelberg, Rui
Gama, F. M.
dc.subject.por.fl_str_mv Antimicrobial peptides
Tuberculosis
Mycobacteria
Antibiotics
Peptide market
Pharmacoeconomical analysis
Science & Technology
topic Antimicrobial peptides
Tuberculosis
Mycobacteria
Antibiotics
Peptide market
Pharmacoeconomical analysis
Science & Technology
description "Available online 24 May 2016"
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/42262
url http://hdl.handle.net/1822/42262
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, João Pedro; Appelberg, Rui; Gama, F. M., Antimicrobial peptides as novel anti-tuberculosis therapeutics. Biotechnology Advances, 34(5), 924-940, 2016
0734-9750
0734-9750
10.1016/j.biotechadv.2016.05.007
27235189
http://www.journals.elsevier.com/biotechnology-advances/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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