Impact of bowel resection margins in node negative colon cancer.

Detalhes bibliográficos
Autor(a) principal: Rocha, R
Data de Publicação: 2016
Outros Autores: Marinho, R, Aparício, D, Fragoso, M, Sousa, M, Gomes, A, Leichsenring, C, Carneiro, C, Geraldes, V, Nunes, V
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.10/1812
Resumo: Surgical intestinal resection margins in colon cancer are a longstanding debate in terms the optimal distance between the tumor and the colonic section line. The aim of this study is to define the oncological outcomes in relation to surgical margins, measured in terms or recurrence rate, time-to-recurrence, disease-free survival and overall survival in a population of node negative colon cancer patients. METHODS: We conducted a retrospective observational longitudinal single institution study. All patients submitted to colon cancer surgery between January 2006 and December 2010 were analyzed. Only node negative patients were included in the study, with analysis of 215 patient charts, divided in two groups (Intestinal margin lower than 5 cm-group 1; and 5 cm or higher-group 2). RESULTS: Mean age of patients was 70.4 years (±11.7), with a male predominance (57.7%). Group 2 more frequently corresponded to Stage II (83 vs 71%; p = 0.05). Global mean total lymph nodes harvested were 12, and were higher in group II than in group I (13.8 ± 8.2 vs 10.4 ± 5.7; p = 0.001). In terms of time-to-recurrence patients of group 2 had longer time than patients of group 1 (32.3 ± 12.1 vs 21.8 ± 13.8 months; p = 0.03), as well as a lower recurrence rate in group I (13.7 vs 17.2%), despite not statistically significant. CONCLUSIONS: This study has showed that patients with 5 cm or higher bowel resection margins had longer time-to-recurrence that was statistically significant. Recurrence rates were lower in the group of patients with longer surgical margins, however not statistically significant.
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spelling Impact of bowel resection margins in node negative colon cancer.Colonic neoplasmsNeoplasias do colónSurgical intestinal resection margins in colon cancer are a longstanding debate in terms the optimal distance between the tumor and the colonic section line. The aim of this study is to define the oncological outcomes in relation to surgical margins, measured in terms or recurrence rate, time-to-recurrence, disease-free survival and overall survival in a population of node negative colon cancer patients. METHODS: We conducted a retrospective observational longitudinal single institution study. All patients submitted to colon cancer surgery between January 2006 and December 2010 were analyzed. Only node negative patients were included in the study, with analysis of 215 patient charts, divided in two groups (Intestinal margin lower than 5 cm-group 1; and 5 cm or higher-group 2). RESULTS: Mean age of patients was 70.4 years (±11.7), with a male predominance (57.7%). Group 2 more frequently corresponded to Stage II (83 vs 71%; p = 0.05). Global mean total lymph nodes harvested were 12, and were higher in group II than in group I (13.8 ± 8.2 vs 10.4 ± 5.7; p = 0.001). In terms of time-to-recurrence patients of group 2 had longer time than patients of group 1 (32.3 ± 12.1 vs 21.8 ± 13.8 months; p = 0.03), as well as a lower recurrence rate in group I (13.7 vs 17.2%), despite not statistically significant. CONCLUSIONS: This study has showed that patients with 5 cm or higher bowel resection margins had longer time-to-recurrence that was statistically significant. Recurrence rates were lower in the group of patients with longer surgical margins, however not statistically significant.SpringerPlusRepositório do Hospital Prof. Doutor Fernando FonsecaRocha, RMarinho, RAparício, DFragoso, MSousa, MGomes, ALeichsenring, CCarneiro, CGeraldes, VNunes, V2017-03-07T16:33:40Z2016-01-01T00:00:00Z2016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/1812engSpringerplus. 2016 Nov 11;5(1):1959. eCollection 2016.2193-180110.1186/s40064-016-3650-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:52:33Zoai:repositorio.hff.min-saude.pt:10400.10/1812Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:52:51.441149Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Impact of bowel resection margins in node negative colon cancer.
title Impact of bowel resection margins in node negative colon cancer.
spellingShingle Impact of bowel resection margins in node negative colon cancer.
Rocha, R
Colonic neoplasms
Neoplasias do colón
title_short Impact of bowel resection margins in node negative colon cancer.
title_full Impact of bowel resection margins in node negative colon cancer.
title_fullStr Impact of bowel resection margins in node negative colon cancer.
title_full_unstemmed Impact of bowel resection margins in node negative colon cancer.
title_sort Impact of bowel resection margins in node negative colon cancer.
author Rocha, R
author_facet Rocha, R
Marinho, R
Aparício, D
Fragoso, M
Sousa, M
Gomes, A
Leichsenring, C
Carneiro, C
Geraldes, V
Nunes, V
author_role author
author2 Marinho, R
Aparício, D
Fragoso, M
Sousa, M
Gomes, A
Leichsenring, C
Carneiro, C
Geraldes, V
Nunes, V
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Hospital Prof. Doutor Fernando Fonseca
dc.contributor.author.fl_str_mv Rocha, R
Marinho, R
Aparício, D
Fragoso, M
Sousa, M
Gomes, A
Leichsenring, C
Carneiro, C
Geraldes, V
Nunes, V
dc.subject.por.fl_str_mv Colonic neoplasms
Neoplasias do colón
topic Colonic neoplasms
Neoplasias do colón
description Surgical intestinal resection margins in colon cancer are a longstanding debate in terms the optimal distance between the tumor and the colonic section line. The aim of this study is to define the oncological outcomes in relation to surgical margins, measured in terms or recurrence rate, time-to-recurrence, disease-free survival and overall survival in a population of node negative colon cancer patients. METHODS: We conducted a retrospective observational longitudinal single institution study. All patients submitted to colon cancer surgery between January 2006 and December 2010 were analyzed. Only node negative patients were included in the study, with analysis of 215 patient charts, divided in two groups (Intestinal margin lower than 5 cm-group 1; and 5 cm or higher-group 2). RESULTS: Mean age of patients was 70.4 years (±11.7), with a male predominance (57.7%). Group 2 more frequently corresponded to Stage II (83 vs 71%; p = 0.05). Global mean total lymph nodes harvested were 12, and were higher in group II than in group I (13.8 ± 8.2 vs 10.4 ± 5.7; p = 0.001). In terms of time-to-recurrence patients of group 2 had longer time than patients of group 1 (32.3 ± 12.1 vs 21.8 ± 13.8 months; p = 0.03), as well as a lower recurrence rate in group I (13.7 vs 17.2%), despite not statistically significant. CONCLUSIONS: This study has showed that patients with 5 cm or higher bowel resection margins had longer time-to-recurrence that was statistically significant. Recurrence rates were lower in the group of patients with longer surgical margins, however not statistically significant.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01T00:00:00Z
2016-01-01T00:00:00Z
2017-03-07T16:33:40Z
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2193-1801
10.1186/s40064-016-3650-y
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