Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs

Detalhes bibliográficos
Autor(a) principal: Roda, Ana
Data de Publicação: 2021
Outros Autores: Paiva, Alexandre, Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/142606
Resumo: ERC-2016-CoG 725034
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spelling Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugsCelecoxibLTTMNSAIDSolubilityTherapeutic liquid formulationsPharmaceutical ScienceERC-2016-CoG 725034Most nonsteroidal anti-inflammatory drugs (NSAIDs) present poor aqueous solubility, impairing their efficiency in physiological media. In this context, Low Transition Temperature Mixtures (LTTMs) are a promising platform to overcome drugs’ poor solubility, forming therapeutic liquid formulations. In this work, the LTTMs of citric acid:L-arginine:water (C:A:W) and glyc-erol:sorbitol (G:S) were studied in terms of their features and assessed in terms of their ability to increase the solubility of six NSAIDs in physiological media. The physicochemical properties of LTTMs were characterized by state-of-art techniques commonly used for these systems. The cyto-toxicity of G:S was also evaluated in L929 mouse fibroblasts and the viscosity, polarity, and pH properties of the studied mixtures were related to the solubility of NSAIDs. The pH and polarity were the parameters that most influenced the drugs’ solubility. Ibuprofen, naproxen, ketoprofen, indomethacin, and flurbiprofen did not present any solubility improvement in the formulations tested. However, concentrated mixtures of C:A:W or G:S in the physiologic-mimicked media (PBS) rendered a celecoxib solubility 4 and 5 times higher than PBS, respectively. These therapeutic liquid formulations of celecoxib in C:A:W or G:S can be a promising tool to increase celecoxib’s therapeutic efficiency in local applications.DQ - Departamento de QuímicaLAQV@REQUIMTERUNRoda, AnaPaiva, AlexandreDuarte, Ana Rita C.2022-07-28T22:25:19Z2021-10-052021-10-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/142606eng1999-4923PURE: 45671973https://doi.org/10.3390/pharmaceutics13101620info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:20:25Zoai:run.unl.pt:10362/142606Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:25.286963Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
title Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
spellingShingle Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
Roda, Ana
Celecoxib
LTTM
NSAID
Solubility
Therapeutic liquid formulations
Pharmaceutical Science
title_short Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
title_full Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
title_fullStr Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
title_full_unstemmed Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
title_sort Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
author Roda, Ana
author_facet Roda, Ana
Paiva, Alexandre
Duarte, Ana Rita C.
author_role author
author2 Paiva, Alexandre
Duarte, Ana Rita C.
author2_role author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Roda, Ana
Paiva, Alexandre
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Celecoxib
LTTM
NSAID
Solubility
Therapeutic liquid formulations
Pharmaceutical Science
topic Celecoxib
LTTM
NSAID
Solubility
Therapeutic liquid formulations
Pharmaceutical Science
description ERC-2016-CoG 725034
publishDate 2021
dc.date.none.fl_str_mv 2021-10-05
2021-10-05T00:00:00Z
2022-07-28T22:25:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/142606
url http://hdl.handle.net/10362/142606
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
PURE: 45671973
https://doi.org/10.3390/pharmaceutics13101620
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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