Initial Results of the International Efforts in Screening New Agents against Candida auris
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8551 |
Resumo: | This article belongs to the Special Issue Biology, Immunology, Epidemiology, and Therapy of Fungal Infections: A Themed Issue Dedicated to Professor David A. Stevens. |
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Initial Results of the International Efforts in Screening New Agents against Candida aurisCandida aurisCandida SpeciesAntifungal DrugsChitin Synthase InhibitorDiphenyl Diselenidein vitro Susceptibility AssaysNikkomycin ZOrganoselenium CompoundsInfecções Sistémicas e ZoonosesThis article belongs to the Special Issue Biology, Immunology, Epidemiology, and Therapy of Fungal Infections: A Themed Issue Dedicated to Professor David A. Stevens.Background: Candida auris is an emergent fungal pathogen and a global concern, mostly due to its resistance to many currently available antifungal drugs. Objective: Thus, in response to this challenge, we evaluated the in vitro activity of potential new drugs, diphenyl diselenide (PhSe)2 and nikkomycin Z (nikZ), alone and in association with currently available antifungals (azoles, echinocandins, and polyenes) against Candida auris. Methods: Clinical isolates of C. auris were tested in vitro. (PhSe)2 and nikZ activities were tested alone and in combination with amphotericin B, fluconazole, or the echinocandins, micafungin and caspofungin. Results: (PhSe)2 alone was unable to inhibit C. auris, and antagonism or indifferent effects were observed in the combination of this compound with the antifungals tested. NikZ appeared not active alone either, but frequently acted cooperatively with conventional antifungals. Conclusion: Our data show that (PhSe)2 appears to not have a good potential to be a candidate in the development of new drugs to treat C. auris, but that nikZ is worthy of further study.his work was accomplished with support from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil, within the scope of the Capes-PrInt Program—Financing Code 001MDPIRepositório Científico do Instituto Nacional de SaúdePoester, Vanice RodriguesMunhoz, Lívia SilveiraBenelli, Jéssica LouiseMelo, Aryse MartinsAl-Hatmi, Abdullah M.S.Larwood, David J.Martinez, MarifeStevens, David A.Xavier, Melissa Orzechowski2023-03-16T12:24:00Z2022-07-252022-07-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8551engJ Fungi (Basel). 2022 Jul 25;8(8):771. doi: 10.3390/jof80807712309-608X10.3390/jof8080771info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:38ZPortal AgregadorONG |
| dc.title.none.fl_str_mv |
Initial Results of the International Efforts in Screening New Agents against Candida auris |
| title |
Initial Results of the International Efforts in Screening New Agents against Candida auris |
| spellingShingle |
Initial Results of the International Efforts in Screening New Agents against Candida auris Poester, Vanice Rodrigues Candida auris Candida Species Antifungal Drugs Chitin Synthase Inhibitor Diphenyl Diselenide in vitro Susceptibility Assays Nikkomycin Z Organoselenium Compounds Infecções Sistémicas e Zoonoses |
| title_short |
Initial Results of the International Efforts in Screening New Agents against Candida auris |
| title_full |
Initial Results of the International Efforts in Screening New Agents against Candida auris |
| title_fullStr |
Initial Results of the International Efforts in Screening New Agents against Candida auris |
| title_full_unstemmed |
Initial Results of the International Efforts in Screening New Agents against Candida auris |
| title_sort |
Initial Results of the International Efforts in Screening New Agents against Candida auris |
| author |
Poester, Vanice Rodrigues |
| author_facet |
Poester, Vanice Rodrigues Munhoz, Lívia Silveira Benelli, Jéssica Louise Melo, Aryse Martins Al-Hatmi, Abdullah M.S. Larwood, David J. Martinez, Marife Stevens, David A. Xavier, Melissa Orzechowski |
| author_role |
author |
| author2 |
Munhoz, Lívia Silveira Benelli, Jéssica Louise Melo, Aryse Martins Al-Hatmi, Abdullah M.S. Larwood, David J. Martinez, Marife Stevens, David A. Xavier, Melissa Orzechowski |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Poester, Vanice Rodrigues Munhoz, Lívia Silveira Benelli, Jéssica Louise Melo, Aryse Martins Al-Hatmi, Abdullah M.S. Larwood, David J. Martinez, Marife Stevens, David A. Xavier, Melissa Orzechowski |
| dc.subject.por.fl_str_mv |
Candida auris Candida Species Antifungal Drugs Chitin Synthase Inhibitor Diphenyl Diselenide in vitro Susceptibility Assays Nikkomycin Z Organoselenium Compounds Infecções Sistémicas e Zoonoses |
| topic |
Candida auris Candida Species Antifungal Drugs Chitin Synthase Inhibitor Diphenyl Diselenide in vitro Susceptibility Assays Nikkomycin Z Organoselenium Compounds Infecções Sistémicas e Zoonoses |
| description |
This article belongs to the Special Issue Biology, Immunology, Epidemiology, and Therapy of Fungal Infections: A Themed Issue Dedicated to Professor David A. Stevens. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-07-25 2022-07-25T00:00:00Z 2023-03-16T12:24:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8551 |
| url |
http://hdl.handle.net/10400.18/8551 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
J Fungi (Basel). 2022 Jul 25;8(8):771. doi: 10.3390/jof8080771 2309-608X 10.3390/jof8080771 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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