Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2017000200007 |
Resumo: | Introduction:Acute pancreatitis (AP) induced by hypertriglyc-eridemia (HTG) can be treated with therapeutic plasma exchange (TPE), resulting in rapid reduction of triglyceride level. However, there are no definitive comparative studies that prove the real benefits of this therapy. Objectives: Comparison of treatment methods (TPE versus conventional) in patients with HTG AP during a period of 12 years (2000-2012). Methods:Retrospective, descriptive and inferential analysis of 37 patients, evaluating: gender, age, personal pathologic history, severity of disease, HTG values and evolution depending on treatment with therapeutic plasma exchange (TPE) or with conventional therapy (C). Results:Both groups TPE and C demonstrated homogeneity considering gender (p = 0.647), age (43.5 ± 9.74 years TPE vs 45.30 ± 9.90 years C; p = 0.320), prior AP episode (40% TPE vs 40.7% C; p = 1.0), chronic alcohol consumption (50% TPE vs 70.4% C; p = 0.275) and severity disease scores: APACHE II (p = 0.054) and Ranson (p = 0.258). More than one secondary HTG risk factor was presented in 45.95% of patients. TPE group presented higher TG levels at admission: 4850 ± 2802 mg/dL vs 1845 ± 1858 mg/dL (p = 0.001). No significant statistical differences were observed considering length of hospital stay [14.2 ± 6.8 days vs 13.5 ± 9.0 days (p = 0.56)] or mortality rate (p = 0.47). At discharge, TG reduction was greater in TPE group: 4433.70 ± 2896.08 mg/dL 91.41% vs 1582.95 ± 2051.06 mg/dL 83,92% (p = 0.002). Six minor complications associated to TPE occurred. Discussion/Conclusion: Despite the selection bias (retrospective study), a greater TG reduction was observed with TPE technique. Complications associated with the technique were simple to resolve. |
id |
RCAP_038b15182680d11883e0c1f680f8fb64 |
---|---|
oai_identifier_str |
oai:scielo:S0872-671X2017000200007 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma ExchangeAcute DiseaseHypertriglyceridemia/therapyPancreatitis/therapyPlasma ExchangeIntroduction:Acute pancreatitis (AP) induced by hypertriglyc-eridemia (HTG) can be treated with therapeutic plasma exchange (TPE), resulting in rapid reduction of triglyceride level. However, there are no definitive comparative studies that prove the real benefits of this therapy. Objectives: Comparison of treatment methods (TPE versus conventional) in patients with HTG AP during a period of 12 years (2000-2012). Methods:Retrospective, descriptive and inferential analysis of 37 patients, evaluating: gender, age, personal pathologic history, severity of disease, HTG values and evolution depending on treatment with therapeutic plasma exchange (TPE) or with conventional therapy (C). Results:Both groups TPE and C demonstrated homogeneity considering gender (p = 0.647), age (43.5 ± 9.74 years TPE vs 45.30 ± 9.90 years C; p = 0.320), prior AP episode (40% TPE vs 40.7% C; p = 1.0), chronic alcohol consumption (50% TPE vs 70.4% C; p = 0.275) and severity disease scores: APACHE II (p = 0.054) and Ranson (p = 0.258). More than one secondary HTG risk factor was presented in 45.95% of patients. TPE group presented higher TG levels at admission: 4850 ± 2802 mg/dL vs 1845 ± 1858 mg/dL (p = 0.001). No significant statistical differences were observed considering length of hospital stay [14.2 ± 6.8 days vs 13.5 ± 9.0 days (p = 0.56)] or mortality rate (p = 0.47). At discharge, TG reduction was greater in TPE group: 4433.70 ± 2896.08 mg/dL 91.41% vs 1582.95 ± 2051.06 mg/dL 83,92% (p = 0.002). Six minor complications associated to TPE occurred. Discussion/Conclusion: Despite the selection bias (retrospective study), a greater TG reduction was observed with TPE technique. Complications associated with the technique were simple to resolve.Sociedade Portuguesa de Medicina Interna2017-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2017000200007Medicina Interna v.24 n.2 2017reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2017000200007Ferreira,Diana M.Lobo,FilipeFonseca,João PedroMendes,Patrícia A.Aragão,AntónioFerreira,ManuelaTomaz,JorgeCarvalho,Armando deinfo:eu-repo/semantics/openAccess2024-02-06T17:08:06Zoai:scielo:S0872-671X2017000200007Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:44.119095Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange |
title |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange |
spellingShingle |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange Ferreira,Diana M. Acute Disease Hypertriglyceridemia/therapy Pancreatitis/therapy Plasma Exchange |
title_short |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange |
title_full |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange |
title_fullStr |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange |
title_full_unstemmed |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange |
title_sort |
Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma Exchange |
author |
Ferreira,Diana M. |
author_facet |
Ferreira,Diana M. Lobo,Filipe Fonseca,João Pedro Mendes,Patrícia A. Aragão,António Ferreira,Manuela Tomaz,Jorge Carvalho,Armando de |
author_role |
author |
author2 |
Lobo,Filipe Fonseca,João Pedro Mendes,Patrícia A. Aragão,António Ferreira,Manuela Tomaz,Jorge Carvalho,Armando de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira,Diana M. Lobo,Filipe Fonseca,João Pedro Mendes,Patrícia A. Aragão,António Ferreira,Manuela Tomaz,Jorge Carvalho,Armando de |
dc.subject.por.fl_str_mv |
Acute Disease Hypertriglyceridemia/therapy Pancreatitis/therapy Plasma Exchange |
topic |
Acute Disease Hypertriglyceridemia/therapy Pancreatitis/therapy Plasma Exchange |
description |
Introduction:Acute pancreatitis (AP) induced by hypertriglyc-eridemia (HTG) can be treated with therapeutic plasma exchange (TPE), resulting in rapid reduction of triglyceride level. However, there are no definitive comparative studies that prove the real benefits of this therapy. Objectives: Comparison of treatment methods (TPE versus conventional) in patients with HTG AP during a period of 12 years (2000-2012). Methods:Retrospective, descriptive and inferential analysis of 37 patients, evaluating: gender, age, personal pathologic history, severity of disease, HTG values and evolution depending on treatment with therapeutic plasma exchange (TPE) or with conventional therapy (C). Results:Both groups TPE and C demonstrated homogeneity considering gender (p = 0.647), age (43.5 ± 9.74 years TPE vs 45.30 ± 9.90 years C; p = 0.320), prior AP episode (40% TPE vs 40.7% C; p = 1.0), chronic alcohol consumption (50% TPE vs 70.4% C; p = 0.275) and severity disease scores: APACHE II (p = 0.054) and Ranson (p = 0.258). More than one secondary HTG risk factor was presented in 45.95% of patients. TPE group presented higher TG levels at admission: 4850 ± 2802 mg/dL vs 1845 ± 1858 mg/dL (p = 0.001). No significant statistical differences were observed considering length of hospital stay [14.2 ± 6.8 days vs 13.5 ± 9.0 days (p = 0.56)] or mortality rate (p = 0.47). At discharge, TG reduction was greater in TPE group: 4433.70 ± 2896.08 mg/dL 91.41% vs 1582.95 ± 2051.06 mg/dL 83,92% (p = 0.002). Six minor complications associated to TPE occurred. Discussion/Conclusion: Despite the selection bias (retrospective study), a greater TG reduction was observed with TPE technique. Complications associated with the technique were simple to resolve. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2017000200007 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2017000200007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2017000200007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Medicina Interna |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Medicina Interna |
dc.source.none.fl_str_mv |
Medicina Interna v.24 n.2 2017 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137294574157824 |