Rare Presentation of Primary Hyperparathyroidism in a Young Woman
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19616 |
Resumo: | Even though primary hyperparathyroidism (PHPT) is a common endocrine disorder, due to better and more regular screening, the usual presentation is only seen in less than 15% of cases of PHPT. The authors present the case of a young female patient with a previous medical history of depression and nephrolithiasis, with one year of bone pain, that had become progressively worse and disabling. In the initial work-up, several lytic bone lesions and moderate hypercalcemia were found, leading to admission of the patient in the Internal Medicine ward for investigation and treatment. The ensuing investigation revealed PHPT due to hyperfunctioning parathyroid adenoma. The patient underwent a parathyroidectomy and at the follow-up assessment two months after discharge, she reported no symptoms and a computer tomography scan showed regression of the lytic lesions. This case is a reminder that severe symptomatic PHPT, a rare form in developed countries nowadays, still exists, and even though it is a medical condition, collaboration with surgical specialties is necessary to ensure the best possible treatment and prognosis. |
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Rare Presentation of Primary Hyperparathyroidism in a Young WomanApresentação Rara de Hiperparatiroidismo Primário numa Mulher JovemDoenças dos Ossos/etiologiaHipercalcemiaHiperparatiroidismo Primário/complicaçõesBone Diseases/etiologyHypercalcemiaHyperparathyroidism, Primary/complicationsEven though primary hyperparathyroidism (PHPT) is a common endocrine disorder, due to better and more regular screening, the usual presentation is only seen in less than 15% of cases of PHPT. The authors present the case of a young female patient with a previous medical history of depression and nephrolithiasis, with one year of bone pain, that had become progressively worse and disabling. In the initial work-up, several lytic bone lesions and moderate hypercalcemia were found, leading to admission of the patient in the Internal Medicine ward for investigation and treatment. The ensuing investigation revealed PHPT due to hyperfunctioning parathyroid adenoma. The patient underwent a parathyroidectomy and at the follow-up assessment two months after discharge, she reported no symptoms and a computer tomography scan showed regression of the lytic lesions. This case is a reminder that severe symptomatic PHPT, a rare form in developed countries nowadays, still exists, and even though it is a medical condition, collaboration with surgical specialties is necessary to ensure the best possible treatment and prognosis.Embora o hiperparatiroidismo primário (HPTP) seja uma doença endócrina comum, com a evolução e a melhoria dos métodos de rastreio, a apresentação clássica é apenas observada em menos de 15% dos casos. Os autores apresentam o caso de uma jovem com antecedentes de síndrome depressiva e nefrolitíase, com história de um ano de dor óssea, incapacitante e de agravamento progressivo. Na avaliação inicial, é de realçar a deteção de lesões ósseas líticas graves e hipercalcemia moderada, o que levou ao internamento da doente para investigação e tratamento. O estudo seguinte possibilitou o diagnóstico de HPTP por adenoma da paratiroide hiperfuncionante. A doente foi submetida a paratiroidectomia e na reavaliação dois meses depois da alta apresentava-se assintomática e com regressão das lesões líticas na imagem de tomografia computorizada. Este caso serve para relembrar que as manifestações muito sintomáticas de HPTP, embora raras nos países desenvolvidos, ainda existem e, que embora sejam quase sempre benignas, a abordagem multidisciplinar com as especialidades cirúrgicas é essencial para a melhor abordagem terapêutica e para um melhor prognóstico.Ordem dos Médicos2023-06-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19616Acta Médica Portuguesa; Vol. 36 No. 11 (2023): November; 746-750Acta Médica Portuguesa; Vol. 36 N.º 11 (2023): Novembro; 746-7501646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19616https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19616/15185Direitos de Autor (c) 2023 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessAraújo, IsabelBrochado, Ana IsabelBranco Carvalho, InêsMateus, SofiaMartins Baptista, António2023-11-05T03:00:35Zoai:ojs.www.actamedicaportuguesa.com:article/19616Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:54:27.989802Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Rare Presentation of Primary Hyperparathyroidism in a Young Woman Apresentação Rara de Hiperparatiroidismo Primário numa Mulher Jovem |
title |
Rare Presentation of Primary Hyperparathyroidism in a Young Woman |
spellingShingle |
Rare Presentation of Primary Hyperparathyroidism in a Young Woman Araújo, Isabel Doenças dos Ossos/etiologia Hipercalcemia Hiperparatiroidismo Primário/complicações Bone Diseases/etiology Hypercalcemia Hyperparathyroidism, Primary/complications |
title_short |
Rare Presentation of Primary Hyperparathyroidism in a Young Woman |
title_full |
Rare Presentation of Primary Hyperparathyroidism in a Young Woman |
title_fullStr |
Rare Presentation of Primary Hyperparathyroidism in a Young Woman |
title_full_unstemmed |
Rare Presentation of Primary Hyperparathyroidism in a Young Woman |
title_sort |
Rare Presentation of Primary Hyperparathyroidism in a Young Woman |
author |
Araújo, Isabel |
author_facet |
Araújo, Isabel Brochado, Ana Isabel Branco Carvalho, Inês Mateus, Sofia Martins Baptista, António |
author_role |
author |
author2 |
Brochado, Ana Isabel Branco Carvalho, Inês Mateus, Sofia Martins Baptista, António |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Araújo, Isabel Brochado, Ana Isabel Branco Carvalho, Inês Mateus, Sofia Martins Baptista, António |
dc.subject.por.fl_str_mv |
Doenças dos Ossos/etiologia Hipercalcemia Hiperparatiroidismo Primário/complicações Bone Diseases/etiology Hypercalcemia Hyperparathyroidism, Primary/complications |
topic |
Doenças dos Ossos/etiologia Hipercalcemia Hiperparatiroidismo Primário/complicações Bone Diseases/etiology Hypercalcemia Hyperparathyroidism, Primary/complications |
description |
Even though primary hyperparathyroidism (PHPT) is a common endocrine disorder, due to better and more regular screening, the usual presentation is only seen in less than 15% of cases of PHPT. The authors present the case of a young female patient with a previous medical history of depression and nephrolithiasis, with one year of bone pain, that had become progressively worse and disabling. In the initial work-up, several lytic bone lesions and moderate hypercalcemia were found, leading to admission of the patient in the Internal Medicine ward for investigation and treatment. The ensuing investigation revealed PHPT due to hyperfunctioning parathyroid adenoma. The patient underwent a parathyroidectomy and at the follow-up assessment two months after discharge, she reported no symptoms and a computer tomography scan showed regression of the lytic lesions. This case is a reminder that severe symptomatic PHPT, a rare form in developed countries nowadays, still exists, and even though it is a medical condition, collaboration with surgical specialties is necessary to ensure the best possible treatment and prognosis. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-20 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19616 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19616 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19616 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19616/15185 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2023 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2023 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 36 No. 11 (2023): November; 746-750 Acta Médica Portuguesa; Vol. 36 N.º 11 (2023): Novembro; 746-750 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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