New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/30652 |
Resumo: | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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New findings in HCV genotype distribution in selected West European, Russian and Israeli regionsGenotypeHCVHepatitis C virusMolecular epidemiologyTransmissionThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).BACKGROUND: HCV affects 185 million people worldwide and leads to death and morbidities. HCV has a high genetic diversity and is classified into seven genotypes and 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance and cure rates depend on HCV geno/subtype (GT). OBJECTIVES: Analysis of epidemiological information and viral GT from patients undergoing viral genotyping in 2011-2015. STUDY DESIGN: Anonymized information from 52 centers was analyzed retrospectively. RESULTS: 37,839 samples were included in the study. We show that the GT distribution is similar throughout Western European countries, with some local differences. Here GTs 1 and 2 prevalences are lower and of GT4 higher than in all previous reports. Israel has a unique GT pattern and in South Russia the GT proportions are more similar to Asia. GTs 5 and 6 were detected in very low proportions. Three cases of the recombinant genotype P were reported in Munich (Germany). In addition, we observed that GT proportion was dependant on patientś gender, age and transmission route: GTs 1b and 2 were significantly more common in female, older, nosocomially-infected patients, while GTs 1a, 3 and 4 were more frequent in male, younger patients infected by tattooing, drug consume, and/or sexual practices. In infections acquired by drug consume, GTs 1a (35.0%) and 3 (28.1%) prevailed. In infections related to sexual practices lower proportion of GT3 (14.0%) and higher of GT4 (20.2%) were detected. GT4 was mostly abundant in MSM (29.6%). HIV coinfection was significantly associated with higher proportions GTs 1a and 4 (42.5% and 19.3%, respectively). CONCLUSION: Genotype prevalence evolves and correlates to epidemiological factors. Continuous surveillance is necessary to better assess hepatitis C infection in Europe and to take appropriate actionsElsevierRepositório ComumKartashev, VladimirDöring, MatthiasNieto, LeonardoColetta, EledaKaiser, RolfSierra, SaletaHCV EuResist Study groupGuerrero, A.Stoiber, H.Paar, C.Vandamme, A. M.Nevens, F.Ranst, M. VanCuypers, L.Braun, P.Ehret, R.Obermeier, M.Schneeweiss, S.Scholten, S.Römer, K.Isernhagen, K.Qurashi, N.Heger, E.Knops, E.Neumann-Fraune, M.Timm, J.Walker, A.Lübke, N.Wedemeyer, H.Wiesch, J. Schulze zurLütgehetmann, M.Polywka, S.Däumer, M.Hoffmann, D.Protzer, U.Marascio, N.Foca, A.Liberto, M. C.Barreca, G. S.Galati, L.Torti, C.Pisani, V.Perno, C. F.Ceccherini-Silberstein, F.Cento, V.Ciotti, M.Zazzi, M.Rossetti, A.De Luca, A.Caudai, C.Mor, O.Devaux, C.Staub, T.Araujo, F.Gomes, P.Cabanas, J.Markin, N.Khomenko, I.Govorukhina, M.Lugovskaya, G.Dontsov, D.Mas, A.Martró, E.Saludes, V.Rodríguez-Frías, F.García, F.Casas, P.Iglesia, A. de laAlados, J. C.Pena-López, M. J.Rodríguez, M. J.Galán, J. C.Suárez, A.Cardeñoso, L.Guerrero, M. D.Vegas-Dominguez, C.Blas-Espada, J.García, R.García-Bujalance, S.Benítez-Gutiérrez, L.Mendoza, C. deMontiel, N.Santos, J.Viciana, I.Delgado, A.Martínez-Sanchez, P. A.Fernández-Alonso, M.Reina, G.Trigo, M.Echeverría, M. J.Aguilera, A.Navarro, D.Bernal, S.Lozano, M. C.Fernández-Cuenca, F.Orduña, A.Eiros, J. M.Ortíz de Lejarazu, R.Martínez-Sapiña, A. M.García-Díaz, A.Haque, T.2019-12-20T12:51:02Z2016-08-01T00:00:00Z2016-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/30652engJ Clin Virol. 2016 Aug;81:82-9. doi: 10.1016/j.jcv.2016.05.01010.1016/j.jcv.2016.05.01010.1016/j.jcv.2016.05.010info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:59Zoai:comum.rcaap.pt:10400.26/30652Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:44.335465Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
New findings in HCV genotype distribution in selected West European, Russian and Israeli regions |
title |
New findings in HCV genotype distribution in selected West European, Russian and Israeli regions |
spellingShingle |
New findings in HCV genotype distribution in selected West European, Russian and Israeli regions Kartashev, Vladimir Genotype HCV Hepatitis C virus Molecular epidemiology Transmission |
title_short |
New findings in HCV genotype distribution in selected West European, Russian and Israeli regions |
title_full |
New findings in HCV genotype distribution in selected West European, Russian and Israeli regions |
title_fullStr |
New findings in HCV genotype distribution in selected West European, Russian and Israeli regions |
title_full_unstemmed |
New findings in HCV genotype distribution in selected West European, Russian and Israeli regions |
title_sort |
New findings in HCV genotype distribution in selected West European, Russian and Israeli regions |
author |
Kartashev, Vladimir |
author_facet |
Kartashev, Vladimir Döring, Matthias Nieto, Leonardo Coletta, Eleda Kaiser, Rolf Sierra, Saleta HCV EuResist Study group Guerrero, A. Stoiber, H. Paar, C. Vandamme, A. M. Nevens, F. Ranst, M. Van Cuypers, L. Braun, P. Ehret, R. Obermeier, M. Schneeweiss, S. Scholten, S. Römer, K. Isernhagen, K. Qurashi, N. Heger, E. Knops, E. Neumann-Fraune, M. Timm, J. Walker, A. Lübke, N. Wedemeyer, H. Wiesch, J. Schulze zur Lütgehetmann, M. Polywka, S. Däumer, M. Hoffmann, D. Protzer, U. Marascio, N. Foca, A. Liberto, M. C. Barreca, G. S. Galati, L. Torti, C. Pisani, V. Perno, C. F. Ceccherini-Silberstein, F. Cento, V. Ciotti, M. Zazzi, M. Rossetti, A. De Luca, A. Caudai, C. Mor, O. Devaux, C. Staub, T. Araujo, F. Gomes, P. Cabanas, J. Markin, N. Khomenko, I. Govorukhina, M. Lugovskaya, G. Dontsov, D. Mas, A. Martró, E. Saludes, V. Rodríguez-Frías, F. García, F. Casas, P. Iglesia, A. de la Alados, J. C. Pena-López, M. J. Rodríguez, M. J. Galán, J. C. Suárez, A. Cardeñoso, L. Guerrero, M. D. Vegas-Dominguez, C. Blas-Espada, J. García, R. García-Bujalance, S. Benítez-Gutiérrez, L. Mendoza, C. de Montiel, N. Santos, J. Viciana, I. Delgado, A. Martínez-Sanchez, P. A. Fernández-Alonso, M. Reina, G. Trigo, M. Echeverría, M. J. Aguilera, A. Navarro, D. Bernal, S. Lozano, M. C. Fernández-Cuenca, F. Orduña, A. Eiros, J. M. Ortíz de Lejarazu, R. Martínez-Sapiña, A. M. García-Díaz, A. Haque, T. |
author_role |
author |
author2 |
Döring, Matthias Nieto, Leonardo Coletta, Eleda Kaiser, Rolf Sierra, Saleta HCV EuResist Study group Guerrero, A. Stoiber, H. Paar, C. Vandamme, A. M. Nevens, F. Ranst, M. Van Cuypers, L. Braun, P. Ehret, R. Obermeier, M. Schneeweiss, S. Scholten, S. Römer, K. Isernhagen, K. Qurashi, N. Heger, E. Knops, E. Neumann-Fraune, M. Timm, J. Walker, A. Lübke, N. Wedemeyer, H. Wiesch, J. Schulze zur Lütgehetmann, M. Polywka, S. Däumer, M. Hoffmann, D. Protzer, U. Marascio, N. Foca, A. Liberto, M. C. Barreca, G. S. Galati, L. Torti, C. Pisani, V. Perno, C. F. Ceccherini-Silberstein, F. Cento, V. Ciotti, M. Zazzi, M. Rossetti, A. De Luca, A. Caudai, C. Mor, O. Devaux, C. Staub, T. Araujo, F. Gomes, P. Cabanas, J. Markin, N. Khomenko, I. Govorukhina, M. Lugovskaya, G. Dontsov, D. Mas, A. Martró, E. Saludes, V. Rodríguez-Frías, F. García, F. Casas, P. Iglesia, A. de la Alados, J. C. Pena-López, M. J. Rodríguez, M. J. Galán, J. C. Suárez, A. Cardeñoso, L. Guerrero, M. D. Vegas-Dominguez, C. Blas-Espada, J. García, R. García-Bujalance, S. Benítez-Gutiérrez, L. Mendoza, C. de Montiel, N. Santos, J. Viciana, I. Delgado, A. Martínez-Sanchez, P. A. Fernández-Alonso, M. Reina, G. Trigo, M. Echeverría, M. J. Aguilera, A. Navarro, D. Bernal, S. Lozano, M. C. Fernández-Cuenca, F. Orduña, A. Eiros, J. M. Ortíz de Lejarazu, R. Martínez-Sapiña, A. M. García-Díaz, A. Haque, T. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Kartashev, Vladimir Döring, Matthias Nieto, Leonardo Coletta, Eleda Kaiser, Rolf Sierra, Saleta HCV EuResist Study group Guerrero, A. Stoiber, H. Paar, C. Vandamme, A. M. Nevens, F. Ranst, M. Van Cuypers, L. Braun, P. Ehret, R. Obermeier, M. Schneeweiss, S. Scholten, S. Römer, K. Isernhagen, K. Qurashi, N. Heger, E. Knops, E. Neumann-Fraune, M. Timm, J. Walker, A. Lübke, N. Wedemeyer, H. Wiesch, J. Schulze zur Lütgehetmann, M. Polywka, S. Däumer, M. Hoffmann, D. Protzer, U. Marascio, N. Foca, A. Liberto, M. C. Barreca, G. S. Galati, L. Torti, C. Pisani, V. Perno, C. F. Ceccherini-Silberstein, F. Cento, V. Ciotti, M. Zazzi, M. Rossetti, A. De Luca, A. Caudai, C. Mor, O. Devaux, C. Staub, T. Araujo, F. Gomes, P. Cabanas, J. Markin, N. Khomenko, I. Govorukhina, M. Lugovskaya, G. Dontsov, D. Mas, A. Martró, E. Saludes, V. Rodríguez-Frías, F. García, F. Casas, P. Iglesia, A. de la Alados, J. C. Pena-López, M. J. Rodríguez, M. J. Galán, J. C. Suárez, A. Cardeñoso, L. Guerrero, M. D. Vegas-Dominguez, C. Blas-Espada, J. García, R. García-Bujalance, S. Benítez-Gutiérrez, L. Mendoza, C. de Montiel, N. Santos, J. Viciana, I. Delgado, A. Martínez-Sanchez, P. A. Fernández-Alonso, M. Reina, G. Trigo, M. Echeverría, M. J. Aguilera, A. Navarro, D. Bernal, S. Lozano, M. C. Fernández-Cuenca, F. Orduña, A. Eiros, J. M. Ortíz de Lejarazu, R. Martínez-Sapiña, A. M. García-Díaz, A. Haque, T. |
dc.subject.por.fl_str_mv |
Genotype HCV Hepatitis C virus Molecular epidemiology Transmission |
topic |
Genotype HCV Hepatitis C virus Molecular epidemiology Transmission |
description |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01T00:00:00Z 2016-08-01T00:00:00Z 2019-12-20T12:51:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/30652 |
url |
http://hdl.handle.net/10400.26/30652 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Clin Virol. 2016 Aug;81:82-9. doi: 10.1016/j.jcv.2016.05.010 10.1016/j.jcv.2016.05.010 10.1016/j.jcv.2016.05.010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129966884945920 |