Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected with Schistosoma haematobium

• Autor(a) principal: Santos, J.
• Data de Publicação: 2014
• Outros Autores: Gouveia, M.J., Vale, N., Delgado, M. de L., Gonçalves, A., da Silva, J.M., Oliveira, C., Xavier, P., Gomes, P., Santos, L.L., Lopes, C., Barros, A., Rinaldi, G., Brindley, P.J., da Costa, J.M., Sousa, M., Botelho, M.C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.18/2309
• topic: Schistosoma Haematobium; Estrogen Metabolites; Infertility

Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schistosome derived catechol-estrogens induce genotoxicity that result in estrogen-DNA adducts. These catechol estrogens and the catechol-estrogen-DNA adducts can be isolated from sera of people infected with S. haematobium. The aim of this study was to study infertility in females infected with S. haematobium and its association with the presence of schistosome-derived catechol-estrogens.