Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/24667 |
Resumo: | The authors gratefully acknowledge the assistance of the staff of Servico de Cardiologia, Hospital de Santa Marta, and Ms. Rute Pinheiro for the help with laboratory work. The study was financially supported by Fundacao para a Ciencia e Tecnologia, PIC/IC/82734/2007 Contract and SFRM/BPD/6308/2009 Grant, and by Liga dos Amigos do Hospital de Santa Marta. |
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Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary InterventionMOLECULAR-MECHANISMSSERUM-LEVELSVASCULAR-PERMEABILITYMOBILIZATIONENDOTHELIAL-GROWTH-FACTORANGIOGENESISDYSFUNCTIONARTERY-DISEASEFACTOR-ACLINICAL-APPLICATIONSThe authors gratefully acknowledge the assistance of the staff of Servico de Cardiologia, Hospital de Santa Marta, and Ms. Rute Pinheiro for the help with laboratory work. The study was financially supported by Fundacao para a Ciencia e Tecnologia, PIC/IC/82734/2007 Contract and SFRM/BPD/6308/2009 Grant, and by Liga dos Amigos do Hospital de Santa Marta.We examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients' serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, 9.0-264 pg/mL versus 419, 212-758 pg/mL; P < 0.001) at baseline. VEGF increased to 1-month (median, IQ: 276, 167-498 pg/mL; P < 0.001) and remained steady to 1-year (median, IQ: 320, 173-497 pg/mL; P < 0.001) approaching control levels. Drug eluting stent apposition and previous medication intake produced a less steep VEGF evolution after intervention (P < 0.05). Baseline VEGF concentration <40.8 pg/mL conveyed increased risk for MACE in a 5-year follow-up. Results reflect a positive role of VEGF in recovery and support its importance in CAD prognosis.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNRamos, C.Napoleão, PatríciaSelas, MafaldaFreixo, CláudiaViegas-Crespo, Ana MariaCarmo, Miguel MotaFerreira, Rui CruzPinheiro, Teresa2017-10-27T22:01:00Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/24667eng0278-0240PURE: 389789https://doi.org/10.1155/2014/135357info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:12:53Zoai:run.unl.pt:10362/24667Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:06.530095Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention |
| title |
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention |
| spellingShingle |
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention Ramos, C. MOLECULAR-MECHANISMS SERUM-LEVELS VASCULAR-PERMEABILITY MOBILIZATION ENDOTHELIAL-GROWTH-FACTOR ANGIOGENESIS DYSFUNCTION ARTERY-DISEASE FACTOR-A CLINICAL-APPLICATIONS |
| title_short |
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention |
| title_full |
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention |
| title_fullStr |
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention |
| title_full_unstemmed |
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention |
| title_sort |
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention |
| author |
Ramos, C. |
| author_facet |
Ramos, C. Napoleão, Patrícia Selas, Mafalda Freixo, Cláudia Viegas-Crespo, Ana Maria Carmo, Miguel Mota Ferreira, Rui Cruz Pinheiro, Teresa |
| author_role |
author |
| author2 |
Napoleão, Patrícia Selas, Mafalda Freixo, Cláudia Viegas-Crespo, Ana Maria Carmo, Miguel Mota Ferreira, Rui Cruz Pinheiro, Teresa |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Ramos, C. Napoleão, Patrícia Selas, Mafalda Freixo, Cláudia Viegas-Crespo, Ana Maria Carmo, Miguel Mota Ferreira, Rui Cruz Pinheiro, Teresa |
| dc.subject.por.fl_str_mv |
MOLECULAR-MECHANISMS SERUM-LEVELS VASCULAR-PERMEABILITY MOBILIZATION ENDOTHELIAL-GROWTH-FACTOR ANGIOGENESIS DYSFUNCTION ARTERY-DISEASE FACTOR-A CLINICAL-APPLICATIONS |
| topic |
MOLECULAR-MECHANISMS SERUM-LEVELS VASCULAR-PERMEABILITY MOBILIZATION ENDOTHELIAL-GROWTH-FACTOR ANGIOGENESIS DYSFUNCTION ARTERY-DISEASE FACTOR-A CLINICAL-APPLICATIONS |
| description |
The authors gratefully acknowledge the assistance of the staff of Servico de Cardiologia, Hospital de Santa Marta, and Ms. Rute Pinheiro for the help with laboratory work. The study was financially supported by Fundacao para a Ciencia e Tecnologia, PIC/IC/82734/2007 Contract and SFRM/BPD/6308/2009 Grant, and by Liga dos Amigos do Hospital de Santa Marta. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2017-10-27T22:01:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/24667 |
| url |
http://hdl.handle.net/10362/24667 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0278-0240 PURE: 389789 https://doi.org/10.1155/2014/135357 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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