Aging Hallmarks: the benefits of physical exercise

Detalhes bibliográficos
Autor(a) principal: Rebelo-Marques, Alexandre
Data de Publicação: 2018
Outros Autores: De Sousa Lages, Adriana, Andrade, Renato, Ribeiro, Carlos Fontes, Mota-Pinto, Anabela, Carrilho, Francisco, Espregueira-Mendes, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/65828
Resumo: World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.
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spelling Aging Hallmarks: the benefits of physical exerciseagingphysical exercisehallmarkscellularmolecularlife spanCiências Médicas::Ciências da SaúdeScience & TechnologyWorld population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.Frontiers MediaUniversidade do MinhoRebelo-Marques, AlexandreDe Sousa Lages, AdrianaAndrade, RenatoRibeiro, Carlos FontesMota-Pinto, AnabelaCarrilho, FranciscoEspregueira-Mendes, João20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/65828engRebelo-Marques A, De Sousa Lages A, Andrade R, Ribeiro CF, Mota-Pinto A, Carrilho F and Espregueira-Mendes J (2018) Aging Hallmarks: The Benefits of Physical Exercise. Front. Endocrinol. 9:258. doi: 10.3389/fendo.2018.002581664-239210.3389/fendo.2018.00258https://www.frontiersin.org/articles/10.3389/fendo.2018.00258/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:36Zoai:repositorium.sdum.uminho.pt:1822/65828Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:29:09.612078Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Aging Hallmarks: the benefits of physical exercise
title Aging Hallmarks: the benefits of physical exercise
spellingShingle Aging Hallmarks: the benefits of physical exercise
Rebelo-Marques, Alexandre
aging
physical exercise
hallmarks
cellular
molecular
life span
Ciências Médicas::Ciências da Saúde
Science & Technology
title_short Aging Hallmarks: the benefits of physical exercise
title_full Aging Hallmarks: the benefits of physical exercise
title_fullStr Aging Hallmarks: the benefits of physical exercise
title_full_unstemmed Aging Hallmarks: the benefits of physical exercise
title_sort Aging Hallmarks: the benefits of physical exercise
author Rebelo-Marques, Alexandre
author_facet Rebelo-Marques, Alexandre
De Sousa Lages, Adriana
Andrade, Renato
Ribeiro, Carlos Fontes
Mota-Pinto, Anabela
Carrilho, Francisco
Espregueira-Mendes, João
author_role author
author2 De Sousa Lages, Adriana
Andrade, Renato
Ribeiro, Carlos Fontes
Mota-Pinto, Anabela
Carrilho, Francisco
Espregueira-Mendes, João
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rebelo-Marques, Alexandre
De Sousa Lages, Adriana
Andrade, Renato
Ribeiro, Carlos Fontes
Mota-Pinto, Anabela
Carrilho, Francisco
Espregueira-Mendes, João
dc.subject.por.fl_str_mv aging
physical exercise
hallmarks
cellular
molecular
life span
Ciências Médicas::Ciências da Saúde
Science & Technology
topic aging
physical exercise
hallmarks
cellular
molecular
life span
Ciências Médicas::Ciências da Saúde
Science & Technology
description World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/65828
url http://hdl.handle.net/1822/65828
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rebelo-Marques A, De Sousa Lages A, Andrade R, Ribeiro CF, Mota-Pinto A, Carrilho F and Espregueira-Mendes J (2018) Aging Hallmarks: The Benefits of Physical Exercise. Front. Endocrinol. 9:258. doi: 10.3389/fendo.2018.00258
1664-2392
10.3389/fendo.2018.00258
https://www.frontiersin.org/articles/10.3389/fendo.2018.00258/full
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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