CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies?
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/49053 |
Resumo: | Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection. |
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CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies?AIDSTfhCD4B cellVaccinePathogenSIVReservoirCiências Médicas::Medicina BásicaScience & TechnologyFollicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection.JE from the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) and from The Canadian HIV Cure Enterprise Team Grant HIG-13305 from the Canadian Institutes of Health Research (CIHR) in partnership with CANFAR and IAS. FM is supported by a fellowship from Fondation du CHU de Québec. CB and YF are supported by fellowships from ANRS. JE acknowledges the support of the Canada Research Chair program. RS is supported by FCT—Fundaçao para a Ciência e a Tecnologia/MEC—Ministério da Educaçao e Ciência através de fundos nacionais e quando aplicavel cofinanciado pelo FEDER, no âmbito do Acordo de Parceria PT2020 referente à unidade de investigaçao n°4293. RS is supported by the Fundaçao para a Ciência e a Tecnologia (FCT) (IF/00021/2014)info:eu-repo/semantics/publishedVersionFrontiers MediaUniversidade do MinhoMoukambi, FélicienRodrigues, VascoFortier, YasminaRabezanahary, HenintsoaBorde, ChloéKrust, BernardAndreani, GuadalupeSilvestre, Ricardo Jorge LealPetrovas, ConstantinosLaforge, MireilleEstaquier, Jérôme2017-02-202017-02-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49053engMoukambi, F., Rodrigues, V., Fortier, Y., Rabezanahary, H., Borde, C., Krust, B., et. al. (2017). CD4 T follicular helper cells and HIV infection: friends or enemies?. Frontiers in immunology, 8.1664-322410.3389/fimmu.2017.00135https://www.frontiersin.org/articles/10.3389/fimmu.2017.00135/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:34:36Zoai:repositorium.sdum.uminho.pt:1822/49053Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:18.499957Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? |
title |
CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? |
spellingShingle |
CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? Moukambi, Félicien AIDS Tfh CD4 B cell Vaccine Pathogen SIV Reservoir Ciências Médicas::Medicina Básica Science & Technology |
title_short |
CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? |
title_full |
CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? |
title_fullStr |
CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? |
title_full_unstemmed |
CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? |
title_sort |
CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? |
author |
Moukambi, Félicien |
author_facet |
Moukambi, Félicien Rodrigues, Vasco Fortier, Yasmina Rabezanahary, Henintsoa Borde, Chloé Krust, Bernard Andreani, Guadalupe Silvestre, Ricardo Jorge Leal Petrovas, Constantinos Laforge, Mireille Estaquier, Jérôme |
author_role |
author |
author2 |
Rodrigues, Vasco Fortier, Yasmina Rabezanahary, Henintsoa Borde, Chloé Krust, Bernard Andreani, Guadalupe Silvestre, Ricardo Jorge Leal Petrovas, Constantinos Laforge, Mireille Estaquier, Jérôme |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Moukambi, Félicien Rodrigues, Vasco Fortier, Yasmina Rabezanahary, Henintsoa Borde, Chloé Krust, Bernard Andreani, Guadalupe Silvestre, Ricardo Jorge Leal Petrovas, Constantinos Laforge, Mireille Estaquier, Jérôme |
dc.subject.por.fl_str_mv |
AIDS Tfh CD4 B cell Vaccine Pathogen SIV Reservoir Ciências Médicas::Medicina Básica Science & Technology |
topic |
AIDS Tfh CD4 B cell Vaccine Pathogen SIV Reservoir Ciências Médicas::Medicina Básica Science & Technology |
description |
Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-20 2017-02-20T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/49053 |
url |
http://hdl.handle.net/1822/49053 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Moukambi, F., Rodrigues, V., Fortier, Y., Rabezanahary, H., Borde, C., Krust, B., et. al. (2017). CD4 T follicular helper cells and HIV infection: friends or enemies?. Frontiers in immunology, 8. 1664-3224 10.3389/fimmu.2017.00135 https://www.frontiersin.org/articles/10.3389/fimmu.2017.00135/full |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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