Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8312 |
Resumo: | This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention? |
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Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU StudiesAcrylamideGlycidamideExposure LevelTime-trendHuman BiomonitoringAcrilamidaNível de ExposiçãoBiomonitorização HumanaDeterminantes da Saúde e da DoençaThis article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations. The Norwegian Institute of Public Health (NIPH) has contributed to the funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements have partly been funded by the Research Council of Norway through research projects (275903 and 268465).MDPIRepositório Científico do Instituto Nacional de SaúdePoteser, MichaelLaguzzi, FedericaSchettgen, ThomasVogel, NinaWeber, TillZimmermann, PhilippHahn, DomenicaKolossa-Gehring, MarikeNamorado, SóniaVan Nieuwenhuyse, AnAppenzeller, BriceHalldorsson, ThorhallurEiríksdóttir, ÁsaHaug, Line SmåstuenThomsen, CathrineBarbone, FabioRosolen, ValentinaRAMBAUD, LoicRIOU, MargauxGöen, ThomasNübler, StefanieSchäfer, MoritzHaji-Abbas-Zarrabi, KarinGilles, LieseRodriguez Martin, LauraSchoeters, GretaSepai, OvnairGovarts, EvaMoshammer, Hanns2022-11-15T12:38:10Z2022-08-172022-08-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8312engToxics. 2022 Aug 17;10(8):481. doi: 10.3390/toxics100804812305-630410.3390/toxics10080481info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:30Zoai:repositorio.insa.pt:10400.18/8312Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:57.466736Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies |
| title |
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies |
| spellingShingle |
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies Poteser, Michael Acrylamide Glycidamide Exposure Level Time-trend Human Biomonitoring Acrilamida Nível de Exposição Biomonitorização Humana Determinantes da Saúde e da Doença |
| title_short |
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies |
| title_full |
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies |
| title_fullStr |
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies |
| title_full_unstemmed |
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies |
| title_sort |
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies |
| author |
Poteser, Michael |
| author_facet |
Poteser, Michael Laguzzi, Federica Schettgen, Thomas Vogel, Nina Weber, Till Zimmermann, Philipp Hahn, Domenica Kolossa-Gehring, Marike Namorado, Sónia Van Nieuwenhuyse, An Appenzeller, Brice Halldorsson, Thorhallur Eiríksdóttir, Ása Haug, Line Småstuen Thomsen, Cathrine Barbone, Fabio Rosolen, Valentina RAMBAUD, Loic RIOU, Margaux Göen, Thomas Nübler, Stefanie Schäfer, Moritz Haji-Abbas-Zarrabi, Karin Gilles, Liese Rodriguez Martin, Laura Schoeters, Greta Sepai, Ovnair Govarts, Eva Moshammer, Hanns |
| author_role |
author |
| author2 |
Laguzzi, Federica Schettgen, Thomas Vogel, Nina Weber, Till Zimmermann, Philipp Hahn, Domenica Kolossa-Gehring, Marike Namorado, Sónia Van Nieuwenhuyse, An Appenzeller, Brice Halldorsson, Thorhallur Eiríksdóttir, Ása Haug, Line Småstuen Thomsen, Cathrine Barbone, Fabio Rosolen, Valentina RAMBAUD, Loic RIOU, Margaux Göen, Thomas Nübler, Stefanie Schäfer, Moritz Haji-Abbas-Zarrabi, Karin Gilles, Liese Rodriguez Martin, Laura Schoeters, Greta Sepai, Ovnair Govarts, Eva Moshammer, Hanns |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Poteser, Michael Laguzzi, Federica Schettgen, Thomas Vogel, Nina Weber, Till Zimmermann, Philipp Hahn, Domenica Kolossa-Gehring, Marike Namorado, Sónia Van Nieuwenhuyse, An Appenzeller, Brice Halldorsson, Thorhallur Eiríksdóttir, Ása Haug, Line Småstuen Thomsen, Cathrine Barbone, Fabio Rosolen, Valentina RAMBAUD, Loic RIOU, Margaux Göen, Thomas Nübler, Stefanie Schäfer, Moritz Haji-Abbas-Zarrabi, Karin Gilles, Liese Rodriguez Martin, Laura Schoeters, Greta Sepai, Ovnair Govarts, Eva Moshammer, Hanns |
| dc.subject.por.fl_str_mv |
Acrylamide Glycidamide Exposure Level Time-trend Human Biomonitoring Acrilamida Nível de Exposição Biomonitorização Humana Determinantes da Saúde e da Doença |
| topic |
Acrylamide Glycidamide Exposure Level Time-trend Human Biomonitoring Acrilamida Nível de Exposição Biomonitorização Humana Determinantes da Saúde e da Doença |
| description |
This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention? |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-15T12:38:10Z 2022-08-17 2022-08-17T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/8312 |
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http://hdl.handle.net/10400.18/8312 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Toxics. 2022 Aug 17;10(8):481. doi: 10.3390/toxics10080481 2305-6304 10.3390/toxics10080481 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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