Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/149792 |
Resumo: | Objective Our aims were to evaluate the correlation between Juvenile Arthritis Disease Activity Score 27-joint reduced count (JADAS27) with erythrocyte sedimentation rate (ESR) and JADAS27 with C-reactive protein (CRP) scores and to test the agreement of both scores on classifying each disease activity state. We also aimed at verifying the correlation of the 2 scores across juvenile idiopathic arthritis (JIA) categories and to check the correlation between JADAS27-ESR and clinical JADAS27 (JADAS27 without ESR). Methods A nationwide cohort of patients with JIA registered in the Portuguese Register, Reuma.pt, was studied. JADAS27-CRP was adapted by replacing ESR with CRP level as the inflammatory marker. JADAS27-CRP was calculated similarly to JADAS27-ESR as the simple linear sum of its 4 components. Pearson's correlations and K statistics were used in the analyses. Results A total of 358 children had full data to calculate JADAS27; 65.4% were female and the mean ± SD disease duration was 11.8 ± 9.1 years. The correlation coefficient between JADAS27-ESR and JADAS27-CRP was 0.967 (P < 0.0001), although the correlation coefficient between ESR and CRP level was 0.335 (P < 0.0001). The strong correlation between JADAS27-ESR and JADAS27-CRP was maintained when compared within each JIA category. The agreement between JADAS27-ESR and JADAS27-CRP across the 4 activity states was very good, showing 91.1% of the observations in agreement; K = 0.867 (95% confidence interval 0.824-0.91). The correlation between JADAS27 with ESR and JADAS27 without ESR was high (r = 0.97, P < 0.0001). Conclusion JADAS27 based on CRP level correlated closely with JADAS27-ESR across all disease activity states and JIA categories, indicating that both measures can be used in clinical practice. Moreover, the correlation of JADAS27 with and without ESR was also high, suggesting that this tool might be useful even in the absence of laboratorial measures. |
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Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein levelResults from the portuguese registerRheumatologyObjective Our aims were to evaluate the correlation between Juvenile Arthritis Disease Activity Score 27-joint reduced count (JADAS27) with erythrocyte sedimentation rate (ESR) and JADAS27 with C-reactive protein (CRP) scores and to test the agreement of both scores on classifying each disease activity state. We also aimed at verifying the correlation of the 2 scores across juvenile idiopathic arthritis (JIA) categories and to check the correlation between JADAS27-ESR and clinical JADAS27 (JADAS27 without ESR). Methods A nationwide cohort of patients with JIA registered in the Portuguese Register, Reuma.pt, was studied. JADAS27-CRP was adapted by replacing ESR with CRP level as the inflammatory marker. JADAS27-CRP was calculated similarly to JADAS27-ESR as the simple linear sum of its 4 components. Pearson's correlations and K statistics were used in the analyses. Results A total of 358 children had full data to calculate JADAS27; 65.4% were female and the mean ± SD disease duration was 11.8 ± 9.1 years. The correlation coefficient between JADAS27-ESR and JADAS27-CRP was 0.967 (P < 0.0001), although the correlation coefficient between ESR and CRP level was 0.335 (P < 0.0001). The strong correlation between JADAS27-ESR and JADAS27-CRP was maintained when compared within each JIA category. The agreement between JADAS27-ESR and JADAS27-CRP across the 4 activity states was very good, showing 91.1% of the observations in agreement; K = 0.867 (95% confidence interval 0.824-0.91). The correlation between JADAS27 with ESR and JADAS27 without ESR was high (r = 0.97, P < 0.0001). Conclusion JADAS27 based on CRP level correlated closely with JADAS27-ESR across all disease activity states and JIA categories, indicating that both measures can be used in clinical practice. Moreover, the correlation of JADAS27 with and without ESR was also high, suggesting that this tool might be useful even in the absence of laboratorial measures.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNMourão, Ana F.Santos, Maria J.Melo-Gomes, JoséMartins, Fernando M.Costa, José A.Ramos, FilipaBrito, IvaDuarte, CátiaFigueira, RicardoFigueiredo, GuilhermeFurtado, CarolinaLopes, AnaOliveira, MargaridaMaria Rodrigues, AnaSalgado, ManuelSousa, MiguelBranco, JaimeFonseca, João E.Canhão, Helena2023-02-27T22:22:11Z2014-042014-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://hdl.handle.net/10362/149792eng2151-464XPURE: 47802335https://doi.org/10.1002/acr.22215info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:38Zoai:run.unl.pt:10362/149792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:51.644309Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level Results from the portuguese register |
title |
Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level |
spellingShingle |
Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level Mourão, Ana F. Rheumatology |
title_short |
Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level |
title_full |
Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level |
title_fullStr |
Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level |
title_full_unstemmed |
Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level |
title_sort |
Using the juvenile arthritis disease activity score based on erythrocyte sedimentation rate or C-reactive protein level |
author |
Mourão, Ana F. |
author_facet |
Mourão, Ana F. Santos, Maria J. Melo-Gomes, José Martins, Fernando M. Costa, José A. Ramos, Filipa Brito, Iva Duarte, Cátia Figueira, Ricardo Figueiredo, Guilherme Furtado, Carolina Lopes, Ana Oliveira, Margarida Maria Rodrigues, Ana Salgado, Manuel Sousa, Miguel Branco, Jaime Fonseca, João E. Canhão, Helena |
author_role |
author |
author2 |
Santos, Maria J. Melo-Gomes, José Martins, Fernando M. Costa, José A. Ramos, Filipa Brito, Iva Duarte, Cátia Figueira, Ricardo Figueiredo, Guilherme Furtado, Carolina Lopes, Ana Oliveira, Margarida Maria Rodrigues, Ana Salgado, Manuel Sousa, Miguel Branco, Jaime Fonseca, João E. Canhão, Helena |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Mourão, Ana F. Santos, Maria J. Melo-Gomes, José Martins, Fernando M. Costa, José A. Ramos, Filipa Brito, Iva Duarte, Cátia Figueira, Ricardo Figueiredo, Guilherme Furtado, Carolina Lopes, Ana Oliveira, Margarida Maria Rodrigues, Ana Salgado, Manuel Sousa, Miguel Branco, Jaime Fonseca, João E. Canhão, Helena |
dc.subject.por.fl_str_mv |
Rheumatology |
topic |
Rheumatology |
description |
Objective Our aims were to evaluate the correlation between Juvenile Arthritis Disease Activity Score 27-joint reduced count (JADAS27) with erythrocyte sedimentation rate (ESR) and JADAS27 with C-reactive protein (CRP) scores and to test the agreement of both scores on classifying each disease activity state. We also aimed at verifying the correlation of the 2 scores across juvenile idiopathic arthritis (JIA) categories and to check the correlation between JADAS27-ESR and clinical JADAS27 (JADAS27 without ESR). Methods A nationwide cohort of patients with JIA registered in the Portuguese Register, Reuma.pt, was studied. JADAS27-CRP was adapted by replacing ESR with CRP level as the inflammatory marker. JADAS27-CRP was calculated similarly to JADAS27-ESR as the simple linear sum of its 4 components. Pearson's correlations and K statistics were used in the analyses. Results A total of 358 children had full data to calculate JADAS27; 65.4% were female and the mean ± SD disease duration was 11.8 ± 9.1 years. The correlation coefficient between JADAS27-ESR and JADAS27-CRP was 0.967 (P < 0.0001), although the correlation coefficient between ESR and CRP level was 0.335 (P < 0.0001). The strong correlation between JADAS27-ESR and JADAS27-CRP was maintained when compared within each JIA category. The agreement between JADAS27-ESR and JADAS27-CRP across the 4 activity states was very good, showing 91.1% of the observations in agreement; K = 0.867 (95% confidence interval 0.824-0.91). The correlation between JADAS27 with ESR and JADAS27 without ESR was high (r = 0.97, P < 0.0001). Conclusion JADAS27 based on CRP level correlated closely with JADAS27-ESR across all disease activity states and JIA categories, indicating that both measures can be used in clinical practice. Moreover, the correlation of JADAS27 with and without ESR was also high, suggesting that this tool might be useful even in the absence of laboratorial measures. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04 2014-04-01T00:00:00Z 2023-02-27T22:22:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/149792 |
url |
http://hdl.handle.net/10362/149792 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2151-464X PURE: 47802335 https://doi.org/10.1002/acr.22215 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138128875749376 |