Expressão da caderina na discondroplasia tibial
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/5731 |
Resumo: | By immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particular phenotype of lesion chondrocytes, and cadherin may be involved in apoptosis of chondrocytes of TD lesion. Another possibility, is that a low level of calcium in the lesion may be responsible for the observed upregulation. The results of the present study suggest that the formation of the dyschondroplastic lesion is not merely due to the impaired terminal differentiation of lesion chondrocytes and that other mechanisms are probably involved in TD etiology. Further studies will be necessary to provide insight into the precise nature of the condition. |
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Expressão da caderina na discondroplasia tibialdiscondroplasia da tibiacaderinaimuno-histoquímicaBy immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particular phenotype of lesion chondrocytes, and cadherin may be involved in apoptosis of chondrocytes of TD lesion. Another possibility, is that a low level of calcium in the lesion may be responsible for the observed upregulation. The results of the present study suggest that the formation of the dyschondroplastic lesion is not merely due to the impaired terminal differentiation of lesion chondrocytes and that other mechanisms are probably involved in TD etiology. Further studies will be necessary to provide insight into the precise nature of the condition.2012-11-19T12:48:36Z2012-11-192010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/5731http://hdl.handle.net/10174/5731porCapela e Silva F, Lamy E, Pereira A, Reis J, Potes J, Cabrita AS. Expressão da caderina na discondroplasia tibial. Arq Bras Med Vet Zootec 2010; 62: 214-218.214-218.http://www.scielo.br/pdf/abmvz/v62n1/v62n1a30.pdfArquivo Brasileiro Medicina Veterinaria Zootecnia62ICAAMfcs@uevora.ptecsl@uevora.ptapereira@uevora.ptjacpotes@uevora.ptnd222Capela e Silva, FLamy, EPereira, APotes, JCabrita, ASinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:44:52Zoai:dspace.uevora.pt:10174/5731Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:00:46.243743Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Expressão da caderina na discondroplasia tibial |
title |
Expressão da caderina na discondroplasia tibial |
spellingShingle |
Expressão da caderina na discondroplasia tibial Capela e Silva, F discondroplasia da tibia caderina imuno-histoquímica |
title_short |
Expressão da caderina na discondroplasia tibial |
title_full |
Expressão da caderina na discondroplasia tibial |
title_fullStr |
Expressão da caderina na discondroplasia tibial |
title_full_unstemmed |
Expressão da caderina na discondroplasia tibial |
title_sort |
Expressão da caderina na discondroplasia tibial |
author |
Capela e Silva, F |
author_facet |
Capela e Silva, F Lamy, E Pereira, A Potes, J Cabrita, AS |
author_role |
author |
author2 |
Lamy, E Pereira, A Potes, J Cabrita, AS |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Capela e Silva, F Lamy, E Pereira, A Potes, J Cabrita, AS |
dc.subject.por.fl_str_mv |
discondroplasia da tibia caderina imuno-histoquímica |
topic |
discondroplasia da tibia caderina imuno-histoquímica |
description |
By immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particular phenotype of lesion chondrocytes, and cadherin may be involved in apoptosis of chondrocytes of TD lesion. Another possibility, is that a low level of calcium in the lesion may be responsible for the observed upregulation. The results of the present study suggest that the formation of the dyschondroplastic lesion is not merely due to the impaired terminal differentiation of lesion chondrocytes and that other mechanisms are probably involved in TD etiology. Further studies will be necessary to provide insight into the precise nature of the condition. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01T00:00:00Z 2012-11-19T12:48:36Z 2012-11-19 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/5731 http://hdl.handle.net/10174/5731 |
url |
http://hdl.handle.net/10174/5731 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Capela e Silva F, Lamy E, Pereira A, Reis J, Potes J, Cabrita AS. Expressão da caderina na discondroplasia tibial. Arq Bras Med Vet Zootec 2010; 62: 214-218. 214-218. http://www.scielo.br/pdf/abmvz/v62n1/v62n1a30.pdf Arquivo Brasileiro Medicina Veterinaria Zootecnia 62 ICAAM fcs@uevora.pt ecsl@uevora.pt apereira@uevora.pt jacpotes@uevora.pt nd 222 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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