Expressão da caderina na discondroplasia tibial

Detalhes bibliográficos
Autor(a) principal: Capela e Silva, F
Data de Publicação: 2010
Outros Autores: Lamy, E, Pereira, A, Potes, J, Cabrita, AS
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/5731
Resumo: By immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particular phenotype of lesion chondrocytes, and cadherin may be involved in apoptosis of chondrocytes of TD lesion. Another possibility, is that a low level of calcium in the lesion may be responsible for the observed upregulation. The results of the present study suggest that the formation of the dyschondroplastic lesion is not merely due to the impaired terminal differentiation of lesion chondrocytes and that other mechanisms are probably involved in TD etiology. Further studies will be necessary to provide insight into the precise nature of the condition.
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spelling Expressão da caderina na discondroplasia tibialdiscondroplasia da tibiacaderinaimuno-histoquímicaBy immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particular phenotype of lesion chondrocytes, and cadherin may be involved in apoptosis of chondrocytes of TD lesion. Another possibility, is that a low level of calcium in the lesion may be responsible for the observed upregulation. The results of the present study suggest that the formation of the dyschondroplastic lesion is not merely due to the impaired terminal differentiation of lesion chondrocytes and that other mechanisms are probably involved in TD etiology. Further studies will be necessary to provide insight into the precise nature of the condition.2012-11-19T12:48:36Z2012-11-192010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/5731http://hdl.handle.net/10174/5731porCapela e Silva F, Lamy E, Pereira A, Reis J, Potes J, Cabrita AS. Expressão da caderina na discondroplasia tibial. Arq Bras Med Vet Zootec 2010; 62: 214-218.214-218.http://www.scielo.br/pdf/abmvz/v62n1/v62n1a30.pdfArquivo Brasileiro Medicina Veterinaria Zootecnia62ICAAMfcs@uevora.ptecsl@uevora.ptapereira@uevora.ptjacpotes@uevora.ptnd222Capela e Silva, FLamy, EPereira, APotes, JCabrita, ASinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:44:52Zoai:dspace.uevora.pt:10174/5731Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:00:46.243743Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Expressão da caderina na discondroplasia tibial
title Expressão da caderina na discondroplasia tibial
spellingShingle Expressão da caderina na discondroplasia tibial
Capela e Silva, F
discondroplasia da tibia
caderina
imuno-histoquímica
title_short Expressão da caderina na discondroplasia tibial
title_full Expressão da caderina na discondroplasia tibial
title_fullStr Expressão da caderina na discondroplasia tibial
title_full_unstemmed Expressão da caderina na discondroplasia tibial
title_sort Expressão da caderina na discondroplasia tibial
author Capela e Silva, F
author_facet Capela e Silva, F
Lamy, E
Pereira, A
Potes, J
Cabrita, AS
author_role author
author2 Lamy, E
Pereira, A
Potes, J
Cabrita, AS
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Capela e Silva, F
Lamy, E
Pereira, A
Potes, J
Cabrita, AS
dc.subject.por.fl_str_mv discondroplasia da tibia
caderina
imuno-histoquímica
topic discondroplasia da tibia
caderina
imuno-histoquímica
description By immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particular phenotype of lesion chondrocytes, and cadherin may be involved in apoptosis of chondrocytes of TD lesion. Another possibility, is that a low level of calcium in the lesion may be responsible for the observed upregulation. The results of the present study suggest that the formation of the dyschondroplastic lesion is not merely due to the impaired terminal differentiation of lesion chondrocytes and that other mechanisms are probably involved in TD etiology. Further studies will be necessary to provide insight into the precise nature of the condition.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01T00:00:00Z
2012-11-19T12:48:36Z
2012-11-19
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/5731
http://hdl.handle.net/10174/5731
url http://hdl.handle.net/10174/5731
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Capela e Silva F, Lamy E, Pereira A, Reis J, Potes J, Cabrita AS. Expressão da caderina na discondroplasia tibial. Arq Bras Med Vet Zootec 2010; 62: 214-218.
214-218.
http://www.scielo.br/pdf/abmvz/v62n1/v62n1a30.pdf
Arquivo Brasileiro Medicina Veterinaria Zootecnia
62
ICAAM
fcs@uevora.pt
ecsl@uevora.pt
apereira@uevora.pt
jacpotes@uevora.pt
nd
222
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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