Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Vala, Helena
Data de Publicação: 2020
Outros Autores: Carvalho, Tânia, Pinto, Carlos, Pereira, Maria A., Mesquita, João R., Peleteiro, Maria C., Ferrer, Lluís, Fondevila, Dolores
Tipo de documento: Artigo
Idioma: spa
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50910
Resumo: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinomaBovineCytokeratinImmunohistochemistryInvolucrinOcular squamous cell carcinomaProfilaggrin© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Bovine Ocular Squamous Cell Carcinoma is considered the most common bovine tumour, causing significant economic losses, mainly by abattoir condemnations. To obtain a better insight into the genesis and neoplastic transformation, 19 samples collected at slaughter from Holstein Friesian cattle and diagnosed as Ocular Squamous Cell Carcinoma were studied. Tumours were histologically classified into three categories: poorly (26.3%), moderately (26.3%), and well differentiated (47.4%). Expression of keratins (MNF116 and LP34) and of cornified envelope precursors (involucrin and profilaggrin) was studied. Expression of MNF116 was observed in all carcinomas. LP34 immunostaining was seen in all but three carcinomas, one from each degree. Involucrin immunoreaction was observed in all but one poorly differentiated carcinoma. Profilaggrin was present in only two moderately differentiated carcinomas, in all but one well differentiated, and in all but one poorly differentiated. MNF116 is a useful marker to confirm the epithelial origin of the tumour and stain most neoplastic cells in these tumours. The expression of involucrin and LP34 demonstrates that, in all tumours, cells have reached the final program of differentiation, regardless of the grade. The expression of profilaggrin could indicate molecular changes during malignant transformation but their expression does not seem to be of diagnostic value.This research was funded by Interdisciplinary Investigation Centre for Animal Health (CIISA) from the Faculty of Veterinary Medicine, Lisbon, and by Portuguese Foundation for Science and Technology (FCT) under the project UIDB/04033/2020.MDPIRepositório da Universidade de LisboaVala, HelenaCarvalho, TâniaPinto, CarlosPereira, Maria A.Mesquita, João R.Peleteiro, Maria C.Ferrer, LluísFondevila, Dolores2022-01-21T12:26:45Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50910spaVet Sci. 2020 May 29;7(2):7010.3390/vetsci70200702306-7381info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-14T15:37:54ZPortal AgregadorONG
dc.title.none.fl_str_mv Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma
title Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma
spellingShingle Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma
Vala, Helena
Bovine
Cytokeratin
Immunohistochemistry
Involucrin
Ocular squamous cell carcinoma
Profilaggrin
title_short Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma
title_full Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma
title_fullStr Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma
title_full_unstemmed Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma
title_sort Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma
author Vala, Helena
author_facet Vala, Helena
Carvalho, Tânia
Pinto, Carlos
Pereira, Maria A.
Mesquita, João R.
Peleteiro, Maria C.
Ferrer, Lluís
Fondevila, Dolores
author_role author
author2 Carvalho, Tânia
Pinto, Carlos
Pereira, Maria A.
Mesquita, João R.
Peleteiro, Maria C.
Ferrer, Lluís
Fondevila, Dolores
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Vala, Helena
Carvalho, Tânia
Pinto, Carlos
Pereira, Maria A.
Mesquita, João R.
Peleteiro, Maria C.
Ferrer, Lluís
Fondevila, Dolores
dc.subject.por.fl_str_mv Bovine
Cytokeratin
Immunohistochemistry
Involucrin
Ocular squamous cell carcinoma
Profilaggrin
topic Bovine
Cytokeratin
Immunohistochemistry
Involucrin
Ocular squamous cell carcinoma
Profilaggrin
description © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2022-01-21T12:26:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50910
url http://hdl.handle.net/10451/50910
dc.language.iso.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv Vet Sci. 2020 May 29;7(2):70
10.3390/vetsci7020070
2306-7381
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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