The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/19458 |
Resumo: | Salvia apiana and Salvia farinacea var. Victoria Blue decoctions were screened for diverse bioactivities, including the ability to counteract oxidative and inflammatory events, as well as to act as cytotoxic and antimicrobial agents. Both extracts showed good activities and that of S. apiana origin was particularly effective regarding the ability to prevent lipid peroxidation and to prevent nitric oxide (NO ) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cell line (EC50 = 50 µg/mL). Moreover, it displayed high cytotoxic capacity against hepatocellular carcinoma HepG2, cervical carcinoma HeLa, and breast carcinoma cells MCF-7, but comparatively low effects in porcine liver primary cells, which highlights its selectivity (GI50 = 41–60 µg/mL vs. 362 µg/mL, respectively). Further, it exhibited inhibitory and lethal potential against a panel of Gram-positive and Gram-negative bacteria. It is possible that the bioactive properties of the two Salvia extracts are associated to their phenolic components and, in the particular case of S. apiana, to its richness in phenolic terpenes, namely in rosmanol, hydroxycarnosic acid and a derivative of sageone, which were found in the extract. |
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The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctionsSageBioactivityAntioxidantsAnti-inflammatoryCytotoxicityAntibacterialPhenolic compoundsTerpenesSalvia apiana and Salvia farinacea var. Victoria Blue decoctions were screened for diverse bioactivities, including the ability to counteract oxidative and inflammatory events, as well as to act as cytotoxic and antimicrobial agents. Both extracts showed good activities and that of S. apiana origin was particularly effective regarding the ability to prevent lipid peroxidation and to prevent nitric oxide (NO ) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cell line (EC50 = 50 µg/mL). Moreover, it displayed high cytotoxic capacity against hepatocellular carcinoma HepG2, cervical carcinoma HeLa, and breast carcinoma cells MCF-7, but comparatively low effects in porcine liver primary cells, which highlights its selectivity (GI50 = 41–60 µg/mL vs. 362 µg/mL, respectively). Further, it exhibited inhibitory and lethal potential against a panel of Gram-positive and Gram-negative bacteria. It is possible that the bioactive properties of the two Salvia extracts are associated to their phenolic components and, in the particular case of S. apiana, to its richness in phenolic terpenes, namely in rosmanol, hydroxycarnosic acid and a derivative of sageone, which were found in the extract.Foundation for Science and Technology (FCT), the European Union, the National Strategic Reference Framework (QREN), the European Regional Development Fund (FEDER), and Operational Programme Competitiveness Factors (COMPETE), for funding the Organic Chemistry Research Unit (QOPNA) (FCT UID/QUI/00062/2019) and Mountain Research Center (CIMO) (UID/AGR/00690/2019), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement. A. Fernandes and R. Calhelha thank the national funding by FCT, P.I., through the institutional scientific employment program-contract. Project AgroForWealth (CENTRO-01-0145-FEDER-000001), funded by Centro2020, through FEDER and PT2020, financed the research contract of Susana M. Cardoso.MDPIBiblioteca Digital do IPBAfonso, Andrea Luísa FernandesPereira, Olívia R.Fernandes, ÂngelaCalhelha, Ricardo C.Silva, ArturFerreira, Isabel C.F.R.Cardoso, Susana M.2019-07-30T11:17:46Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/19458engAfonso, Andrea F.; Pereira, Olívia R.; Fernandes, Ângela; Calhelha, Ricardo C.; Silva, Artur; Ferreira, Isabel C.F.R.; Cardoso, Susana M. (2019). The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions. Antioxidants. ISSN 2076-3921. 8:8, p. 1-142076-392110.3390/antiox8080241info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:44:18Zoai:bibliotecadigital.ipb.pt:10198/19458Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:09:55.759390Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
title |
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
spellingShingle |
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions Afonso, Andrea Luísa Fernandes Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
title_short |
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
title_full |
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
title_fullStr |
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
title_full_unstemmed |
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
title_sort |
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
author |
Afonso, Andrea Luísa Fernandes |
author_facet |
Afonso, Andrea Luísa Fernandes Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
author_role |
author |
author2 |
Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Afonso, Andrea Luísa Fernandes Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
dc.subject.por.fl_str_mv |
Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
topic |
Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
description |
Salvia apiana and Salvia farinacea var. Victoria Blue decoctions were screened for diverse bioactivities, including the ability to counteract oxidative and inflammatory events, as well as to act as cytotoxic and antimicrobial agents. Both extracts showed good activities and that of S. apiana origin was particularly effective regarding the ability to prevent lipid peroxidation and to prevent nitric oxide (NO ) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cell line (EC50 = 50 µg/mL). Moreover, it displayed high cytotoxic capacity against hepatocellular carcinoma HepG2, cervical carcinoma HeLa, and breast carcinoma cells MCF-7, but comparatively low effects in porcine liver primary cells, which highlights its selectivity (GI50 = 41–60 µg/mL vs. 362 µg/mL, respectively). Further, it exhibited inhibitory and lethal potential against a panel of Gram-positive and Gram-negative bacteria. It is possible that the bioactive properties of the two Salvia extracts are associated to their phenolic components and, in the particular case of S. apiana, to its richness in phenolic terpenes, namely in rosmanol, hydroxycarnosic acid and a derivative of sageone, which were found in the extract. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07-30T11:17:46Z 2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/19458 |
url |
http://hdl.handle.net/10198/19458 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Afonso, Andrea F.; Pereira, Olívia R.; Fernandes, Ângela; Calhelha, Ricardo C.; Silva, Artur; Ferreira, Isabel C.F.R.; Cardoso, Susana M. (2019). The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions. Antioxidants. ISSN 2076-3921. 8:8, p. 1-14 2076-3921 10.3390/antiox8080241 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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