Dermic diffusion and stratum corneum: a state of the art review of mathematical models
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/3481 |
Resumo: | Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives. |
id |
RCAP_0deffee2b078b3c1af6a089817caff02 |
---|---|
oai_identifier_str |
oai:recipp.ipp.pt:10400.22/3481 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Dermic diffusion and stratum corneum: a state of the art review of mathematical modelsTransdermal diffusionMathematical diffusion modelsFick's LawSensorsHybrid approachTransdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.ElsevierRepositório Científico do Instituto Politécnico do PortoCouto, AnaFernandes, RubenCordeiro, M. Natália D. S.Reis, Sara S.Ribeiro, Rogério T.Pessoa, Ana S. Moura2014-01-28T19:13:01Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/3481porCouto, A., Fernandes, R., Cordeiro, M. N. S., Reis, S. S., Ribeiro, R. T., & Pessoa, A. M. (2014). Dermic diffusion and stratum corneum: A state of the art review of mathematical models. Journal of Controlled Release, 177, 74–83. doi:10.1016/j.jconrel.2013.12.0050168-365910.1016/j.jconrel.2013.12.005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:43:18Zoai:recipp.ipp.pt:10400.22/3481Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:24:28.663682Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Dermic diffusion and stratum corneum: a state of the art review of mathematical models |
title |
Dermic diffusion and stratum corneum: a state of the art review of mathematical models |
spellingShingle |
Dermic diffusion and stratum corneum: a state of the art review of mathematical models Couto, Ana Transdermal diffusion Mathematical diffusion models Fick's Law Sensors Hybrid approach |
title_short |
Dermic diffusion and stratum corneum: a state of the art review of mathematical models |
title_full |
Dermic diffusion and stratum corneum: a state of the art review of mathematical models |
title_fullStr |
Dermic diffusion and stratum corneum: a state of the art review of mathematical models |
title_full_unstemmed |
Dermic diffusion and stratum corneum: a state of the art review of mathematical models |
title_sort |
Dermic diffusion and stratum corneum: a state of the art review of mathematical models |
author |
Couto, Ana |
author_facet |
Couto, Ana Fernandes, Ruben Cordeiro, M. Natália D. S. Reis, Sara S. Ribeiro, Rogério T. Pessoa, Ana S. Moura |
author_role |
author |
author2 |
Fernandes, Ruben Cordeiro, M. Natália D. S. Reis, Sara S. Ribeiro, Rogério T. Pessoa, Ana S. Moura |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Couto, Ana Fernandes, Ruben Cordeiro, M. Natália D. S. Reis, Sara S. Ribeiro, Rogério T. Pessoa, Ana S. Moura |
dc.subject.por.fl_str_mv |
Transdermal diffusion Mathematical diffusion models Fick's Law Sensors Hybrid approach |
topic |
Transdermal diffusion Mathematical diffusion models Fick's Law Sensors Hybrid approach |
description |
Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-28T19:13:01Z 2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/3481 |
url |
http://hdl.handle.net/10400.22/3481 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Couto, A., Fernandes, R., Cordeiro, M. N. S., Reis, S. S., Ribeiro, R. T., & Pessoa, A. M. (2014). Dermic diffusion and stratum corneum: A state of the art review of mathematical models. Journal of Controlled Release, 177, 74–83. doi:10.1016/j.jconrel.2013.12.005 0168-3659 10.1016/j.jconrel.2013.12.005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131338203201536 |