Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious

Detalhes bibliográficos
Autor(a) principal: Messias, A
Data de Publicação: 2019
Outros Autores: Calado, J, Viana, H, Nolasco, F
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3851
Resumo: Nephrotic syndrome in a patient with metastatic melanoma can occur in the context of a paraneoplastic glomerulopathy or as a complica tion of treatment. New oncologic immunotherapies, including immune checkpoint inhibitors, have been frequently associated with interstitial nephritis and, in rare cases, with nephrotic syndrome. This article presents the case of a 52 -year -old man diagnosed with metastatic melanoma who was admitted with acute kidney injury and nephrotic syndrome after having started immune checkpoint inhibitors. After investigation, acute kidney injury was attributed to immunotherapy -associated acute interstitial nephritis, and nephrotic syndrome was found to be the result of AA amyloidosis, which is a rare complication of metastatic melanoma.
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spelling Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the ObviousHCC NEFAmyloidosisImmunotherapyMelanomaNephritisNephrotic syndrome in a patient with metastatic melanoma can occur in the context of a paraneoplastic glomerulopathy or as a complica tion of treatment. New oncologic immunotherapies, including immune checkpoint inhibitors, have been frequently associated with interstitial nephritis and, in rare cases, with nephrotic syndrome. This article presents the case of a 52 -year -old man diagnosed with metastatic melanoma who was admitted with acute kidney injury and nephrotic syndrome after having started immune checkpoint inhibitors. After investigation, acute kidney injury was attributed to immunotherapy -associated acute interstitial nephritis, and nephrotic syndrome was found to be the result of AA amyloidosis, which is a rare complication of metastatic melanoma.Sociedade Portuguesa de Nefrologia e HipertensãoRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEMessias, ACalado, JViana, HNolasco, F2021-09-20T14:34:32Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3851engPort J Nephrol Hypert 2019; 33(4): 252-255info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:44:27Zoai:repositorio.chlc.min-saude.pt:10400.17/3851Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:09.951397Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
spellingShingle Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
Messias, A
HCC NEF
Amyloidosis
Immunotherapy
Melanoma
Nephritis
title_short Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title_full Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title_fullStr Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title_full_unstemmed Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title_sort Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
author Messias, A
author_facet Messias, A
Calado, J
Viana, H
Nolasco, F
author_role author
author2 Calado, J
Viana, H
Nolasco, F
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Messias, A
Calado, J
Viana, H
Nolasco, F
dc.subject.por.fl_str_mv HCC NEF
Amyloidosis
Immunotherapy
Melanoma
Nephritis
topic HCC NEF
Amyloidosis
Immunotherapy
Melanoma
Nephritis
description Nephrotic syndrome in a patient with metastatic melanoma can occur in the context of a paraneoplastic glomerulopathy or as a complica tion of treatment. New oncologic immunotherapies, including immune checkpoint inhibitors, have been frequently associated with interstitial nephritis and, in rare cases, with nephrotic syndrome. This article presents the case of a 52 -year -old man diagnosed with metastatic melanoma who was admitted with acute kidney injury and nephrotic syndrome after having started immune checkpoint inhibitors. After investigation, acute kidney injury was attributed to immunotherapy -associated acute interstitial nephritis, and nephrotic syndrome was found to be the result of AA amyloidosis, which is a rare complication of metastatic melanoma.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-09-20T14:34:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3851
url http://hdl.handle.net/10400.17/3851
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Port J Nephrol Hypert 2019; 33(4): 252-255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia e Hipertensão
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia e Hipertensão
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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