Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons

Detalhes bibliográficos
Autor(a) principal: Valente Nabais, João M.
Data de Publicação: 2011
Outros Autores: Ledesma, Beatriz, Laginhas, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/3328
https://doi.org/10.1002/jps.22757
Resumo: In this work, the adsorption behavior of a tricyclic antidepressant, amitriptyline hydrochloride, onto several activated carbons (ACs) is reported. The adsorption was done using in vitro simulated gastric and intestinal fluid at 37◦C to test the performance of the carbons as treatment in overdose cases. The tested materials were one commercial AC (carbomix) and two ACs produced in our laboratory. The highest adsorption capacity was achieved by carbomix, followed by the laboratory-made carbons that still have a very good performance with adsorption capacity up to 120 and 100 mg/g for the gastric and intestinal fluids, respectively.
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spelling Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbonsIn this work, the adsorption behavior of a tricyclic antidepressant, amitriptyline hydrochloride, onto several activated carbons (ACs) is reported. The adsorption was done using in vitro simulated gastric and intestinal fluid at 37◦C to test the performance of the carbons as treatment in overdose cases. The tested materials were one commercial AC (carbomix) and two ACs produced in our laboratory. The highest adsorption capacity was achieved by carbomix, followed by the laboratory-made carbons that still have a very good performance with adsorption capacity up to 120 and 100 mg/g for the gastric and intestinal fluids, respectively.2012-01-11T15:24:50Z2012-01-112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/3328http://hdl.handle.net/10174/3328https://doi.org/10.1002/jps.22757engValente Nabais, João M.; Ledesma, Beatriz; Laginhas, Carlos. Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons, Journal of Pharmaceutical Sciences, 100, 12, 5096-5099, 2011.jvn@uevora.ptndnd252Valente Nabais, João M.Ledesma, BeatrizLaginhas, Carlosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:40:27Zoai:dspace.uevora.pt:10174/3328Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:58:48.871322Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
title Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
spellingShingle Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
Valente Nabais, João M.
title_short Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
title_full Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
title_fullStr Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
title_full_unstemmed Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
title_sort Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
author Valente Nabais, João M.
author_facet Valente Nabais, João M.
Ledesma, Beatriz
Laginhas, Carlos
author_role author
author2 Ledesma, Beatriz
Laginhas, Carlos
author2_role author
author
dc.contributor.author.fl_str_mv Valente Nabais, João M.
Ledesma, Beatriz
Laginhas, Carlos
description In this work, the adsorption behavior of a tricyclic antidepressant, amitriptyline hydrochloride, onto several activated carbons (ACs) is reported. The adsorption was done using in vitro simulated gastric and intestinal fluid at 37◦C to test the performance of the carbons as treatment in overdose cases. The tested materials were one commercial AC (carbomix) and two ACs produced in our laboratory. The highest adsorption capacity was achieved by carbomix, followed by the laboratory-made carbons that still have a very good performance with adsorption capacity up to 120 and 100 mg/g for the gastric and intestinal fluids, respectively.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01T00:00:00Z
2012-01-11T15:24:50Z
2012-01-11
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/3328
http://hdl.handle.net/10174/3328
https://doi.org/10.1002/jps.22757
url http://hdl.handle.net/10174/3328
https://doi.org/10.1002/jps.22757
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Valente Nabais, João M.; Ledesma, Beatriz; Laginhas, Carlos. Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons, Journal of Pharmaceutical Sciences, 100, 12, 5096-5099, 2011.
jvn@uevora.pt
nd
nd
252
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