Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/3328 https://doi.org/10.1002/jps.22757 |
Resumo: | In this work, the adsorption behavior of a tricyclic antidepressant, amitriptyline hydrochloride, onto several activated carbons (ACs) is reported. The adsorption was done using in vitro simulated gastric and intestinal fluid at 37◦C to test the performance of the carbons as treatment in overdose cases. The tested materials were one commercial AC (carbomix) and two ACs produced in our laboratory. The highest adsorption capacity was achieved by carbomix, followed by the laboratory-made carbons that still have a very good performance with adsorption capacity up to 120 and 100 mg/g for the gastric and intestinal fluids, respectively. |
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Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbonsIn this work, the adsorption behavior of a tricyclic antidepressant, amitriptyline hydrochloride, onto several activated carbons (ACs) is reported. The adsorption was done using in vitro simulated gastric and intestinal fluid at 37◦C to test the performance of the carbons as treatment in overdose cases. The tested materials were one commercial AC (carbomix) and two ACs produced in our laboratory. The highest adsorption capacity was achieved by carbomix, followed by the laboratory-made carbons that still have a very good performance with adsorption capacity up to 120 and 100 mg/g for the gastric and intestinal fluids, respectively.2012-01-11T15:24:50Z2012-01-112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/3328http://hdl.handle.net/10174/3328https://doi.org/10.1002/jps.22757engValente Nabais, João M.; Ledesma, Beatriz; Laginhas, Carlos. Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons, Journal of Pharmaceutical Sciences, 100, 12, 5096-5099, 2011.jvn@uevora.ptndnd252Valente Nabais, João M.Ledesma, BeatrizLaginhas, Carlosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:40:27Zoai:dspace.uevora.pt:10174/3328Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:58:48.871322Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons |
title |
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons |
spellingShingle |
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons Valente Nabais, João M. |
title_short |
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons |
title_full |
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons |
title_fullStr |
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons |
title_full_unstemmed |
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons |
title_sort |
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons |
author |
Valente Nabais, João M. |
author_facet |
Valente Nabais, João M. Ledesma, Beatriz Laginhas, Carlos |
author_role |
author |
author2 |
Ledesma, Beatriz Laginhas, Carlos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Valente Nabais, João M. Ledesma, Beatriz Laginhas, Carlos |
description |
In this work, the adsorption behavior of a tricyclic antidepressant, amitriptyline hydrochloride, onto several activated carbons (ACs) is reported. The adsorption was done using in vitro simulated gastric and intestinal fluid at 37◦C to test the performance of the carbons as treatment in overdose cases. The tested materials were one commercial AC (carbomix) and two ACs produced in our laboratory. The highest adsorption capacity was achieved by carbomix, followed by the laboratory-made carbons that still have a very good performance with adsorption capacity up to 120 and 100 mg/g for the gastric and intestinal fluids, respectively. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01T00:00:00Z 2012-01-11T15:24:50Z 2012-01-11 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/3328 http://hdl.handle.net/10174/3328 https://doi.org/10.1002/jps.22757 |
url |
http://hdl.handle.net/10174/3328 https://doi.org/10.1002/jps.22757 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Valente Nabais, João M.; Ledesma, Beatriz; Laginhas, Carlos. Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons, Journal of Pharmaceutical Sciences, 100, 12, 5096-5099, 2011. jvn@uevora.pt nd nd 252 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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