Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications

Detalhes bibliográficos
Autor(a) principal: Figueiredo, Lígia
Data de Publicação: 2020
Outros Autores: Fonseca, Rita, Pinto, Luís F. V., Ferreira, Frederico Castelo, Almeida, Amélia, Rodrigues, Alexandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/8421
Resumo: The authors thank Bioceramed S.A. for providing the materials used in the present study and Fundação para a Ciência e Tecnologia (FCT) for the PhD grant SFRH/BD/51949/2012. Funding received from FCT (UID/BIO/04565/2019), from Programa Operacional Regional de Lisboa 2020 (Project N. 007317) and PAC (Project 016394) is also acknowledged.
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spelling Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applicationsBioabsorbable polymersChitosanPlasticizersCeramicsMechanical propertiesMicrostructureThe authors thank Bioceramed S.A. for providing the materials used in the present study and Fundação para a Ciência e Tecnologia (FCT) for the PhD grant SFRH/BD/51949/2012. Funding received from FCT (UID/BIO/04565/2019), from Programa Operacional Regional de Lisboa 2020 (Project N. 007317) and PAC (Project 016394) is also acknowledged.Bioabsorbable polymeric fixation devices have been used as an alternative to metallic implants in orthopedics,preventing the stress shielding effect and avoiding a second surgery for implant removal. However,several problems are still associated with current bioabsorbable implants, including the limited mechanical stiffness and strength, and the adverse tissue reactions generated. To minimize or even eliminate the problems associated with these implants, strategies have been developed to synthesize new implant materials based on chitosan. To overcome the brittle behavior of most 3D chitosan-based structures, glycerol and sorbitol were blended to chitosan and the effect of these plasticizers in the produced specimens was analyzed by flexural tests, Berkovich tests, scanning electron microscopy (SEM) and micro-CT analyzes. The improvement of the mechanical properties was also tested by adding ceramics, namely hydroxyapatite powder and biphasic mixtures of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP). In the plasticizers group, the best combination of the measured properties was obtained for chitosan with 10% glycerol (flexural strength of 53.8 MPa and indentation hardness of 19.4 kgf/mm2), while in the ceramics group the best mechanical behavior was obtained for chitosan with 10% HAþβ-TCP powder (flexural strength of 67.5 MPa and indentation hardness 28.2 kgf/mm2). All the tested material compositions were dense and homogeneous, fundamental condition for a good implant performance. These are encouraging results, which support the continued development of chitosan-based materials for orthopedic fixation applications.ElsevierIC-OnlineFigueiredo, LígiaFonseca, RitaPinto, Luís F. V.Ferreira, Frederico CasteloAlmeida, AméliaRodrigues, Alexandra2023-04-19T14:56:31Z2020-032020-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8421engFigueiredo, L., Fonseca, R., Pinto, L. F. V., Ferreira, F. C., Almeida, A., & Rodrigues, A. (2020). Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications. Journal of the Mechanical Behavior of Biomedical Materials, 103. https://doi.org/10.1016/j.jmbbm.2019.1035721751-616110.1016/j.jmbbm.2019.103572metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:57:17Zoai:iconline.ipleiria.pt:10400.8/8421Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:08.868356Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
title Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
spellingShingle Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
Figueiredo, Lígia
Bioabsorbable polymers
Chitosan
Plasticizers
Ceramics
Mechanical properties
Microstructure
title_short Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
title_full Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
title_fullStr Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
title_full_unstemmed Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
title_sort Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
author Figueiredo, Lígia
author_facet Figueiredo, Lígia
Fonseca, Rita
Pinto, Luís F. V.
Ferreira, Frederico Castelo
Almeida, Amélia
Rodrigues, Alexandra
author_role author
author2 Fonseca, Rita
Pinto, Luís F. V.
Ferreira, Frederico Castelo
Almeida, Amélia
Rodrigues, Alexandra
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Figueiredo, Lígia
Fonseca, Rita
Pinto, Luís F. V.
Ferreira, Frederico Castelo
Almeida, Amélia
Rodrigues, Alexandra
dc.subject.por.fl_str_mv Bioabsorbable polymers
Chitosan
Plasticizers
Ceramics
Mechanical properties
Microstructure
topic Bioabsorbable polymers
Chitosan
Plasticizers
Ceramics
Mechanical properties
Microstructure
description The authors thank Bioceramed S.A. for providing the materials used in the present study and Fundação para a Ciência e Tecnologia (FCT) for the PhD grant SFRH/BD/51949/2012. Funding received from FCT (UID/BIO/04565/2019), from Programa Operacional Regional de Lisboa 2020 (Project N. 007317) and PAC (Project 016394) is also acknowledged.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
2020-03-01T00:00:00Z
2023-04-19T14:56:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/8421
url http://hdl.handle.net/10400.8/8421
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Figueiredo, L., Fonseca, R., Pinto, L. F. V., Ferreira, F. C., Almeida, A., & Rodrigues, A. (2020). Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications. Journal of the Mechanical Behavior of Biomedical Materials, 103. https://doi.org/10.1016/j.jmbbm.2019.103572
1751-6161
10.1016/j.jmbbm.2019.103572
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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