Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.23/549 |
Resumo: | From 1907 patients with chronic hepatitis C proposed for treatment, we analysed 1380 (1124 naive and 256 treatment-experienced) with complete follow-up. Genotype and HCV RNA quantification were assayed by commercial tests. Viremia was considered high if >800,000IU/mL, and low if <400,000IU/mL. Liver fibrosis was staged in 614 patients. RESULTS: Genotype 1 was the most frequent (60%), followed by 3 (25%), 4 (9%) and 2 (2%); 3.2% had other or unclassified genotype. Genotype 1 was more prevalent in central Portugal and genotype 4 in the south. Viremia was =800,000IU/mL in 54.6% and <400,000IU/mL in 34.6% of the patients, particularly in genotype 2 (p<0.03) and 4 (p<0.001). Genotype non-1 had a significantly lower viral load (p=0.004). Mild or moderate fibrosis was present in 71.7% and bridging fibrosis or cirrhosis in 28.3%, with no differences among genotypes. Treatment was discontinued in 19.8%. SVR was achieved in 55.3% of naive and 36.3% of re-treated patients. CONCLUSIONS: Standard treatment of chronic hepatitis C in real-life achieves similar results obtained in clinical trials, despite differences of demographic and viral parameters. |
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Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical PracticeHepacivirusHepatitis C CrónicaInterferon-alphaRibavirinaFrom 1907 patients with chronic hepatitis C proposed for treatment, we analysed 1380 (1124 naive and 256 treatment-experienced) with complete follow-up. Genotype and HCV RNA quantification were assayed by commercial tests. Viremia was considered high if >800,000IU/mL, and low if <400,000IU/mL. Liver fibrosis was staged in 614 patients. RESULTS: Genotype 1 was the most frequent (60%), followed by 3 (25%), 4 (9%) and 2 (2%); 3.2% had other or unclassified genotype. Genotype 1 was more prevalent in central Portugal and genotype 4 in the south. Viremia was =800,000IU/mL in 54.6% and <400,000IU/mL in 34.6% of the patients, particularly in genotype 2 (p<0.03) and 4 (p<0.001). Genotype non-1 had a significantly lower viral load (p=0.004). Mild or moderate fibrosis was present in 71.7% and bridging fibrosis or cirrhosis in 28.3%, with no differences among genotypes. Treatment was discontinued in 19.8%. SVR was achieved in 55.3% of naive and 36.3% of re-treated patients. CONCLUSIONS: Standard treatment of chronic hepatitis C in real-life achieves similar results obtained in clinical trials, despite differences of demographic and viral parameters.Update Medical PublishingRepositório Científico do Hospital de BragaVelosa, JSerejo, FBana, TRedondo, ISimão, AVale, AMPires, SMacedo, GMarinho, RPeixe, PSarmento, JMatos, LCalinas, FCarvalho, AFigueiredo, A2013-11-15T15:33:17Z2011-01-01T00:00:00Z2011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/549engHepatogastroenterology. 2011;58(109):1260-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:14Zoai:repositorio.hospitaldebraga.pt:10400.23/549Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:12.091887Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice |
title |
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice |
spellingShingle |
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice Velosa, J Hepacivirus Hepatitis C Crónica Interferon-alpha Ribavirina |
title_short |
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice |
title_full |
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice |
title_fullStr |
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice |
title_full_unstemmed |
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice |
title_sort |
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice |
author |
Velosa, J |
author_facet |
Velosa, J Serejo, F Bana, T Redondo, I Simão, A Vale, AM Pires, S Macedo, G Marinho, R Peixe, P Sarmento, J Matos, L Calinas, F Carvalho, A Figueiredo, A |
author_role |
author |
author2 |
Serejo, F Bana, T Redondo, I Simão, A Vale, AM Pires, S Macedo, G Marinho, R Peixe, P Sarmento, J Matos, L Calinas, F Carvalho, A Figueiredo, A |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Hospital de Braga |
dc.contributor.author.fl_str_mv |
Velosa, J Serejo, F Bana, T Redondo, I Simão, A Vale, AM Pires, S Macedo, G Marinho, R Peixe, P Sarmento, J Matos, L Calinas, F Carvalho, A Figueiredo, A |
dc.subject.por.fl_str_mv |
Hepacivirus Hepatitis C Crónica Interferon-alpha Ribavirina |
topic |
Hepacivirus Hepatitis C Crónica Interferon-alpha Ribavirina |
description |
From 1907 patients with chronic hepatitis C proposed for treatment, we analysed 1380 (1124 naive and 256 treatment-experienced) with complete follow-up. Genotype and HCV RNA quantification were assayed by commercial tests. Viremia was considered high if >800,000IU/mL, and low if <400,000IU/mL. Liver fibrosis was staged in 614 patients. RESULTS: Genotype 1 was the most frequent (60%), followed by 3 (25%), 4 (9%) and 2 (2%); 3.2% had other or unclassified genotype. Genotype 1 was more prevalent in central Portugal and genotype 4 in the south. Viremia was =800,000IU/mL in 54.6% and <400,000IU/mL in 34.6% of the patients, particularly in genotype 2 (p<0.03) and 4 (p<0.001). Genotype non-1 had a significantly lower viral load (p=0.004). Mild or moderate fibrosis was present in 71.7% and bridging fibrosis or cirrhosis in 28.3%, with no differences among genotypes. Treatment was discontinued in 19.8%. SVR was achieved in 55.3% of naive and 36.3% of re-treated patients. CONCLUSIONS: Standard treatment of chronic hepatitis C in real-life achieves similar results obtained in clinical trials, despite differences of demographic and viral parameters. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01T00:00:00Z 2011-01-01T00:00:00Z 2013-11-15T15:33:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.23/549 |
url |
http://hdl.handle.net/10400.23/549 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Hepatogastroenterology. 2011;58(109):1260-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Update Medical Publishing |
publisher.none.fl_str_mv |
Update Medical Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130419453493248 |