Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/6574 |
Resumo: | Erratum in - Corrigendum: Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability. Fagundes GE, Macan TP, Rohr P, Damiani AP, Da Rocha FR, Pereira M, Longaretti LM, Vilela TC, Ceretta LB, Mendes C, Silveira PCL, Teixeira JPF, de Andrade VM. Mutagenesis. 2019 May 29;34(2):215. doi: 10.1093/mutage/gez006. |
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Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instabilityDiabetes MellitusType 2 Diabetes MellitusVitamin D3Erratum in - Corrigendum: Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability. Fagundes GE, Macan TP, Rohr P, Damiani AP, Da Rocha FR, Pereira M, Longaretti LM, Vilela TC, Ceretta LB, Mendes C, Silveira PCL, Teixeira JPF, de Andrade VM. Mutagenesis. 2019 May 29;34(2):215. doi: 10.1093/mutage/gez006.Type 2 diabetes mellitus has undergone a worldwide growth in incidence in the world and has now acquired epidemic status. There is a strong link between type 2 diabetes and vitamin D deficiency. Because vitamin D has beneficial effects on glucose homeostasis, the aim of this study was to evaluate the influence of vitamin D3 supplementation on the modulation of glycaemic control and other metabolic effects, as well as modulation of genomic instability in patients with type 2 diabetes. We evaluated 75 patients with type 2 diabetes, registered in the Integrated Clinics of the University of Southern Santa Catarina. Participants received 4000 IU of vitamin D3 (25(OH)D) supplementation daily for 8 weeks. Blood samples were collected at the beginning and at the end of the supplementation, and 4 weeks after the end of supplementation. The glycidic and lipid profiles [total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein and triglycerides], oxidative stress, DNA damage and 25(OH)D levels were evaluated. Vitamin D3 supplementation for 8 weeks showed enough to significantly increase blood levels of 25(OH)D. A significant difference in lipid profile was observed only in non-HDL cholesterol. Significant changes were observed in glucose homeostasis (fasting glucose and serum insulin) and, in addition, a reduction in the parameters of oxidative stress and DNA damage. There was a significant reduction in the values of 25(OH)D 4 weeks after the end of the supplementation, but levels still remained above baseline. Use of vitamin D supplementation can be an ally in the health modulation of patients with type 2 diabetes mellitusThis work was supported by grants from Conselho Nacional de Pesquisa e Desenvolvimento (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC) and Programa de Pós-Graduação em Ciências da Saúde/ Universidade do Extremo Sul Catarinense.Oxford University Press/ United Kingdom Environmental Mutagen SocietyRepositório Científico do Instituto Nacional de SaúdeFagundes, Gabriela E.Macan, Tamires P.Rohr, PaulaDamiani, Adriani P.Rodrigues da Rocha, FrancianiPereira, MaiaraLongaretti, Luiza M.Vilela, Thais C.Ceretta, Luciane B.Mendes, CaroliniSilveira, Paulo C.L.Teixeira, João Paulo F.Moraes de Andrade, Vanessa2020-05-02T15:28:57Z2019-05-292019-05-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.18/6574engMutagenesis. 2019 May 29;34(2):135-145. doi: 10.1093/mutage/gez0010267-835710.1093/mutage/gez001info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:15Zoai:repositorio.insa.pt:10400.18/6574Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:48.953047Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability |
| title |
Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability |
| spellingShingle |
Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability Fagundes, Gabriela E. Diabetes Mellitus Type 2 Diabetes Mellitus Vitamin D3 |
| title_short |
Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability |
| title_full |
Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability |
| title_fullStr |
Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability |
| title_full_unstemmed |
Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability |
| title_sort |
Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability |
| author |
Fagundes, Gabriela E. |
| author_facet |
Fagundes, Gabriela E. Macan, Tamires P. Rohr, Paula Damiani, Adriani P. Rodrigues da Rocha, Franciani Pereira, Maiara Longaretti, Luiza M. Vilela, Thais C. Ceretta, Luciane B. Mendes, Carolini Silveira, Paulo C.L. Teixeira, João Paulo F. Moraes de Andrade, Vanessa |
| author_role |
author |
| author2 |
Macan, Tamires P. Rohr, Paula Damiani, Adriani P. Rodrigues da Rocha, Franciani Pereira, Maiara Longaretti, Luiza M. Vilela, Thais C. Ceretta, Luciane B. Mendes, Carolini Silveira, Paulo C.L. Teixeira, João Paulo F. Moraes de Andrade, Vanessa |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Fagundes, Gabriela E. Macan, Tamires P. Rohr, Paula Damiani, Adriani P. Rodrigues da Rocha, Franciani Pereira, Maiara Longaretti, Luiza M. Vilela, Thais C. Ceretta, Luciane B. Mendes, Carolini Silveira, Paulo C.L. Teixeira, João Paulo F. Moraes de Andrade, Vanessa |
| dc.subject.por.fl_str_mv |
Diabetes Mellitus Type 2 Diabetes Mellitus Vitamin D3 |
| topic |
Diabetes Mellitus Type 2 Diabetes Mellitus Vitamin D3 |
| description |
Erratum in - Corrigendum: Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability. Fagundes GE, Macan TP, Rohr P, Damiani AP, Da Rocha FR, Pereira M, Longaretti LM, Vilela TC, Ceretta LB, Mendes C, Silveira PCL, Teixeira JPF, de Andrade VM. Mutagenesis. 2019 May 29;34(2):215. doi: 10.1093/mutage/gez006. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-05-29 2019-05-29T00:00:00Z 2020-05-02T15:28:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6574 |
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http://hdl.handle.net/10400.18/6574 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Mutagenesis. 2019 May 29;34(2):135-145. doi: 10.1093/mutage/gez001 0267-8357 10.1093/mutage/gez001 |
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info:eu-repo/semantics/embargoedAccess |
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embargoedAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Oxford University Press/ United Kingdom Environmental Mutagen Society |
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Oxford University Press/ United Kingdom Environmental Mutagen Society |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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