Schistosomiasis and infertility: what do we know?

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Ana Rita
Data de Publicação: 2019
Outros Autores: Luis, Carla, Fernandes, Ruben, Botelho, Monica C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6553
Resumo: There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.
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spelling Schistosomiasis and infertility: what do we know?Catechol-estrogensEstrogen ReceptorsEstrogensFemale InfertilityMale InfertilitySchistosomiasisThere is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.Highlights: In spite of a plethora of epidemiological evidence supporting a key role for schistosome infection for infertility, little is known about the mechanisms of their association. To date, one of the few well characterized mechanisms by which schistosomes interact with their hosts is the estrogenic imbalance and downregulation of the estrogen receptor. Remarkably, our understanding of this mechanism has already been successfully studied in cancer-associated schistosomiasis. The relentless advancement in molecular studies, together with the discovery of novel biomarkers, provide unprecedented opportunities to investigate schistosomiasis and exploit parasite–host relationships for the development of novel strategies of disease control. There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.ElsevierRepositório Científico do Instituto Nacional de SaúdeRibeiro, Ana RitaLuis, CarlaFernandes, RubenBotelho, Monica C.2020-04-29T05:49:51Z2019-122019-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6553engTrends Parasitol. 2019 Dec;35(12):964-971. doi: 10.1016/j.pt.2019.09.001. Epub 2019 Oct 141471-492210.1016/j.pt.2019.09.001info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:31Zoai:repositorio.insa.pt:10400.18/6553Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:15.661772Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Schistosomiasis and infertility: what do we know?
title Schistosomiasis and infertility: what do we know?
spellingShingle Schistosomiasis and infertility: what do we know?
Ribeiro, Ana Rita
Catechol-estrogens
Estrogen Receptors
Estrogens
Female Infertility
Male Infertility
Schistosomiasis
title_short Schistosomiasis and infertility: what do we know?
title_full Schistosomiasis and infertility: what do we know?
title_fullStr Schistosomiasis and infertility: what do we know?
title_full_unstemmed Schistosomiasis and infertility: what do we know?
title_sort Schistosomiasis and infertility: what do we know?
author Ribeiro, Ana Rita
author_facet Ribeiro, Ana Rita
Luis, Carla
Fernandes, Ruben
Botelho, Monica C.
author_role author
author2 Luis, Carla
Fernandes, Ruben
Botelho, Monica C.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Ribeiro, Ana Rita
Luis, Carla
Fernandes, Ruben
Botelho, Monica C.
dc.subject.por.fl_str_mv Catechol-estrogens
Estrogen Receptors
Estrogens
Female Infertility
Male Infertility
Schistosomiasis
topic Catechol-estrogens
Estrogen Receptors
Estrogens
Female Infertility
Male Infertility
Schistosomiasis
description There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
2019-12-01T00:00:00Z
2020-04-29T05:49:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6553
url http://hdl.handle.net/10400.18/6553
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Trends Parasitol. 2019 Dec;35(12):964-971. doi: 10.1016/j.pt.2019.09.001. Epub 2019 Oct 14
1471-4922
10.1016/j.pt.2019.09.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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