Fluorescent products in the crystalline lens of type ii diabetic patients.
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2601 |
Resumo: | A body of evidence suggests that glycation of proteins and the resulting fluorescent products take part in the late complications of diabetes. The purpose of this study was to analyse the fluorescence of lens soluble proteins from diabetic patients. Soluble proteins were obtained from lens with cataract from 20 type II diabetic patients and from 21 non diabetic controls with similar age. The fluorescence of the soluble fraction (EX-360 nm, EM -454 nm) was quantified as a parameter for glycation end products. The glycation of plasma proteins was quantified by fructosamine levels. The fluorescence mean in the group of diabetics was about twice the non diabetic value (p < 0.01). The fluorescence in the diabetics with retinopathy was higher than that of diabetic without retinopathy (p < 0.01). Fructosamine levels were: diabetics 3.1 +/- 1.1 mM, non diabetics 1.9 +/- 0.8 mM (p < 0.001). The results suggest the involvement of fluorescent products, resulting from glycation of proteins, in lens opacification in diabetic patients. |
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Fluorescent products in the crystalline lens of type ii diabetic patients.Productos fluorescentes no cristalino de diabéticos tipo II.A body of evidence suggests that glycation of proteins and the resulting fluorescent products take part in the late complications of diabetes. The purpose of this study was to analyse the fluorescence of lens soluble proteins from diabetic patients. Soluble proteins were obtained from lens with cataract from 20 type II diabetic patients and from 21 non diabetic controls with similar age. The fluorescence of the soluble fraction (EX-360 nm, EM -454 nm) was quantified as a parameter for glycation end products. The glycation of plasma proteins was quantified by fructosamine levels. The fluorescence mean in the group of diabetics was about twice the non diabetic value (p < 0.01). The fluorescence in the diabetics with retinopathy was higher than that of diabetic without retinopathy (p < 0.01). Fructosamine levels were: diabetics 3.1 +/- 1.1 mM, non diabetics 1.9 +/- 0.8 mM (p < 0.001). The results suggest the involvement of fluorescent products, resulting from glycation of proteins, in lens opacification in diabetic patients.A body of evidence suggests that glycation of proteins and the resulting fluorescent products take part in the late complications of diabetes. The purpose of this study was to analyse the fluorescence of lens soluble proteins from diabetic patients. Soluble proteins were obtained from lens with cataract from 20 type II diabetic patients and from 21 non diabetic controls with similar age. The fluorescence of the soluble fraction (EX-360 nm, EM -454 nm) was quantified as a parameter for glycation end products. The glycation of plasma proteins was quantified by fructosamine levels. The fluorescence mean in the group of diabetics was about twice the non diabetic value (p < 0.01). The fluorescence in the diabetics with retinopathy was higher than that of diabetic without retinopathy (p < 0.01). Fructosamine levels were: diabetics 3.1 +/- 1.1 mM, non diabetics 1.9 +/- 0.8 mM (p < 0.001). The results suggest the involvement of fluorescent products, resulting from glycation of proteins, in lens opacification in diabetic patients.Ordem dos Médicos1996-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2601oai:ojs.www.actamedicaportuguesa.com:article/2601Acta Médica Portuguesa; Vol. 9 No. 7-9 (1996): Julho-Setembro; 237-9Acta Médica Portuguesa; Vol. 9 N.º 7-9 (1996): Julho-Setembro; 237-91646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2601https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2601/2013Silva, JFreitas, J PFilipe, PVendrell, ERodrigo, F Ginfo:eu-repo/semantics/openAccess2022-12-20T11:00:49ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Fluorescent products in the crystalline lens of type ii diabetic patients. Productos fluorescentes no cristalino de diabéticos tipo II. |
title |
Fluorescent products in the crystalline lens of type ii diabetic patients. |
spellingShingle |
Fluorescent products in the crystalline lens of type ii diabetic patients. Silva, J |
title_short |
Fluorescent products in the crystalline lens of type ii diabetic patients. |
title_full |
Fluorescent products in the crystalline lens of type ii diabetic patients. |
title_fullStr |
Fluorescent products in the crystalline lens of type ii diabetic patients. |
title_full_unstemmed |
Fluorescent products in the crystalline lens of type ii diabetic patients. |
title_sort |
Fluorescent products in the crystalline lens of type ii diabetic patients. |
author |
Silva, J |
author_facet |
Silva, J Freitas, J P Filipe, P Vendrell, E Rodrigo, F G |
author_role |
author |
author2 |
Freitas, J P Filipe, P Vendrell, E Rodrigo, F G |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva, J Freitas, J P Filipe, P Vendrell, E Rodrigo, F G |
description |
A body of evidence suggests that glycation of proteins and the resulting fluorescent products take part in the late complications of diabetes. The purpose of this study was to analyse the fluorescence of lens soluble proteins from diabetic patients. Soluble proteins were obtained from lens with cataract from 20 type II diabetic patients and from 21 non diabetic controls with similar age. The fluorescence of the soluble fraction (EX-360 nm, EM -454 nm) was quantified as a parameter for glycation end products. The glycation of plasma proteins was quantified by fructosamine levels. The fluorescence mean in the group of diabetics was about twice the non diabetic value (p < 0.01). The fluorescence in the diabetics with retinopathy was higher than that of diabetic without retinopathy (p < 0.01). Fructosamine levels were: diabetics 3.1 +/- 1.1 mM, non diabetics 1.9 +/- 0.8 mM (p < 0.001). The results suggest the involvement of fluorescent products, resulting from glycation of proteins, in lens opacification in diabetic patients. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-09-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2601 oai:ojs.www.actamedicaportuguesa.com:article/2601 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2601 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/2601 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2601 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2601/2013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 9 No. 7-9 (1996): Julho-Setembro; 237-9 Acta Médica Portuguesa; Vol. 9 N.º 7-9 (1996): Julho-Setembro; 237-9 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
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repository.mail.fl_str_mv |
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1777301637070585856 |